Results 21 to 30 of about 94,967 (299)
Nose to brain transport pathways an overview: potential of nanostructured lipid carriers in nose to brain targeting [PDF]
Artificial Cells, Nanomedicine, and Biotechnology, 2017 Many of the therapeutics used for the treatment of brain disorders are not effective and not delivered to the brain due to the complex structure and its barriers. In recent years, many advanced approaches have emerged for the brain drug delivery. Intranasal drug delivery is one of non-invasive approach has gained interest because of direct transport of
Kousalya, Selvaraj +2 more
openaire +2 more sources
Brain-Targeted Intranasal Delivery of Zotepine Microemulsion: Pharmacokinetics and Pharmacodynamics
Pharmaceutics, 2022 The purpose of our study was to improve the solubility, bioavailability, and efficacy of zotepine (ZTP) by brain-targeted intranasal delivery of microemulsion (ME) and its physicochemical properties, the pharmacokinetic and pharmacodynamic parameters ...
Sravanthi Reddy Pailla +5 more
doaj +1 more source
RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
Drug Delivery, 2020 Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases. Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and provide a certain protective effect from brain damage after cerebral ischemia.
Rubin Hao +4 more
doaj +1 more source
Cerebral ischemic stroke and different approaches for treatment of stroke
Future Journal of Pharmaceutical Sciences, 2021 Background Cerebral ischemia can be considered a lethal disease as it is a leading cause of death worldwide with no prompt line of treatment. The factors which make this disease more fatal are failure of drugs while crossing BBB, very low availability of
Ghanashyam Arun Girnar +1 more
doaj +1 more source
Nose-to-brain delivery of antiviral drugs: A way to overcome their active efflux? [PDF]
, 2018 Although several viruses can easily infect the central nervous system (CNS), antiviral drugs often show dramatic difficulties in penetrating the brain from the bloodstream since they are substrates of active efflux transporters (AETs). These transporters,
Dalpiaz, Alessandro, Pavan, Barbara
core +2 more sources
Pharmaceutics, 2020 Direct nose-to-brain delivery has been raised as a non-invasive powerful strategy to deliver drugs to the brain bypassing the blood-brain barrier (BBB). This study aimed at preparing and characterizing an innovative composite formulation, associating the
Thomas Adnet +10 more
doaj +1 more source
Drug Delivery, 2022 Ischemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents loaded in nanocarriers to be ...
Eman A. Bseiso +4 more
doaj +1 more source
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William +5 more
core +3 more sources
Nasal Drug Delivery Systems: An Overview [PDF]
, 2015 Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R. +3 more
core +1 more source
Pharmaceutics, 2023 The intranasal route has been suggested as a promising alternative to improve the direct transport of molecules to the brain, avoiding the need to cross the blood–brain barrier (BBB).
Joana Torres +9 more
doaj +1 more source