Results 11 to 20 of about 94,967 (299)
Nose-to-Brain delivery of insulin for Alzheimer’s disease [PDF]
ADMET and DMPK, 2015 The transport of small molecules, peptides and proteins via the olfactory epithelium and along olfactory and trigeminal nerve pathways from the nasal cavity to the brain is very well known and clinically established for central nervous system (CNS ...
Martina Stützle +3 more
doaj +5 more sources
Promising brain biodistribution of insulin via intranasal dry powder for nose-to-brain delivery [PDF]
HeliyonNose-to-brain delivery (NTBD) offering potential benefits for treating Alzheimer's disease. In previous research, insulin dry powder (IDP) formulation for NTBD was developed, exhibiting favorable stability. This study aims to conduct in vitro and ex vivo
Cynthia Marisca Muntu +3 more
doaj +2 more sources
Nose-to-brain delivery of insulin nanoparticles for diabetes management: A review
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2023 Hyperglycemia and the onset of insulin resistance or deficiency, or both, are the hallmarks of the group of diseases known as diabetes. Ultimately, insulin subcutaneous injection is the most effective treatment for diabetic patients.
Manoj Kumbhare +2 more
doaj +1 more source
Pharmaceutics, 2022 Intranasal administration is a promising route for brain drug delivery. However, it can be difficult to formulate drugs that have low water solubility into high strength intranasal solutions.
Patrícia C. Pires +3 more
doaj +1 more source
The Journal of Pharmacology and Experimental Therapeutics, 2019 The global prevalence of neurologic disorders is rising, and yet we are still unable to deliver most drug molecules, in therapeutic quantities, to the brain. The blood brain barrier consists of a tight layer of endothelial cells surrounded by astrocyte foot processes, and these anatomic features constitute a significant barrier to drug transport from ...
Uchegbu, I +4 more
openaire +3 more sources
Pharmaceutics, 2022 Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety ...
Margarida Alberto +3 more
doaj +1 more source
Current Research in Pharmacology and Drug Discovery, 2022 Central nervous system (CNS)-related diseases are difficult to treat as most therapeutic agents they cannot reach the brain tissue, mainly due to the blood-brain barrier (BBB), arguably the tightest barrier between the human body and cerebral parenchyma,
Esteban G. Figueroa +5 more
doaj +1 more source
Transnasal-brain delivery of nanomedicines for neurodegenerative diseases
Frontiers in Drug Delivery, 2023 Neurodegenerative diseases (NDs) have become a serious global health problem as the population ages. Traditionally, treatment strategies for NDs have included oral and intravenous administration; however, the blood–brain barrier (BBB) can prevent drugs ...
Xu Zhang +11 more
doaj +1 more source
Nose-to-Brain Delivery of Antioxidants as a Potential Tool for the Therapy of Neurological Diseases
Pharmaceutics, 2020 Oxidative stress has a key role in the pathogenesis of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases and can be an important cause of the damages in cerebral ischemia.
Maria Cristina Bonferoni +5 more
doaj +1 more source
Pharmaceutics, 2023 Rasagiline mesylate (RSM) is a hydrophilic drug with poor oral bioavailability (36%) because of hepatic first-pass metabolism. The present study focuses on delivering RSM directly to the brain through its inclusion within transferosomal in situ gel ...
Hala N. ElShagea +4 more
doaj +1 more source