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Nose-to-brain drug delivery: from bench to bedside [PDF]
Translational NeurodegenerationThere is increasing interest in nose-to-brain delivery as an innovative drug delivery strategy for neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease.
Isabell Drath +2 more
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Pharmaceutics, 2020 Nose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood−brain barrier (BBB) and the ...
Paolo Giunchedi +2 more
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Microemulsion-Based Media in Nose-to-Brain Drug Delivery [PDF]
Pharmaceutics, 2021 Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to other delivery routes, including the most popular oral one.
Anna Froelich +4 more
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Nanoemulsions for “Nose-to-Brain” Drug Delivery [PDF]
Pharmaceutics, 2019 The blood⁻brain barrier (BBB) plays a fundamental role in protecting the brain from toxic substances and therefore also controls and restricts the entry of therapeutic agents. The nasal administration of drugs using the nose-to-brain pathway allows
Maria Cristina Bonferoni +6 more
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EncyclopediaNose-to-brain drug delivery is an innovative approach that leverages the unique anatomical pathways connecting the nasal cavity to the brain, including the olfactory and trigeminal nerve routes.
Linh Thi-Thao Nguyen, Van-An Duong
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Advancements in Nanocarrier Systems for Nose-to-Brain Drug Delivery [PDF]
PharmaceuticalsIn recent decades, nose-to-brain drug delivery has shown effectiveness in treating many central nervous system diseases. Intranasally administered drugs can be delivered to the brain through the olfactory and trigeminal pathways that bypass the blood ...
Thi-Thao-Linh Nguyen, Van-An Duong
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Chitosan-Based Nanocarriers for Nose to Brain Delivery [PDF]
Applied Sciences, 2019 In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain.
Blessing Atim Aderibigbe, Tobeka Naki
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Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting
Pharmaceutics, 2018 In the field of nasal drug delivery, nose-to-brain delivery is among the most fascinating applications, directly targeting the central nervous system, bypassing the blood brain barrier.
Fabio Sonvico +7 more
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Distribution of insulin in primate brain following nose‐to‐brain transport [PDF]
Alzheimer’s & Dementia: Translational Research & Clinical InterventionsIntroduction Nose‐to‐brain (N2B) insulin delivery has potential for Alzheimer's disease (AD) therapy. However, clinical implementation has been challenging without methods to follow N2B delivery non‐invasively.
Kylie Smith +5 more
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Engineered commensals for targeted nose-to-brain drug delivery
CellShen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic molecules. When engineered to secrete appetite-regulating hormones, intranasal delivery of L. plantarum alleviates obesity-related symptoms in a mouse model.
Matthew Wook Chang
exaly +3 more sources