Results 71 to 80 of about 261,437 (315)
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte beta-selection [PDF]
, 2021 Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu (117318) +13 more
core +1 more source
Using XFEM Techniques to Predict the Damage of aluminum 2024T3 notched under tensile load
Fracture and Structural Integrity, 2019 The objective of this work is to analyze some geometrical effect to predict the damage of aluminum 2024T3 structure after validate numerical model by experimental test. The mechanical of damage behaviour under tensile tests of several plates with notches
Benzaama Abdallah +7 more
doaj +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Regulation of the self-renewal vs. differentiation decision in the C.elegans germline [PDF]
, 2011 Adult stem cells are the basis of our reproductive potential, of tissue growth and maintenance, and of wound healing and regeneration. Ageing phenotypes such as hair loss or brittle bones in fact reflect the gradual decline of the proliferative ...
Kalchhauser, Irene
core +1 more source
Energies, 2018 Drive motors, which are used in the drive modules of electric cars, are interior permanent magnet motors. These motors tend to have high cogging torque and torque ripple, which leads to the generation of high vibration and noise.
Myeong-Hwan Hwang +2 more
doaj +1 more source
Applied Sciences, 2020 This paper provides a complete overview of the applicability of the Equivalent Material Concept in conjunction with the Average Strain Energy Density criterion, to provide predictions of fracture loads in structural materials containing U-notches.
Sergio Cicero +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The interaction of Notch signalling, haemodynamic flow and angiogenesis in Von Hippel-Lindau mutant zebrafish. [PDF]
, 2013 Introduction: There is increasing evidence that the endothelium is able to transduce circulatory force into signals which influence angiogenic behaviour.
Watson, Oliver
core
G3: Genes, Genomes, Genetics, 2019 Genetic analysis of LIN-12/Notch signaling in C. elegans has provided many insights into human biology. Activating missense mutations in the Negative Regulatory Region (NRR) of the ectodomain of LIN-12/Notch were first described in C.
Yuting Deng +3 more
doaj +1 more source
Notch one for activating NOTCH [PDF]
Science-Business eXchange, 2011 Vanderbilt researchers have identified downregulation of NOTCH signaling as a mechanism tumors use to evade the immune system, suggesting that restoring activation of the pathway could improve cancer immunotherapy. Researchers have been split on whether it is better to up- or downregulate NOTCH.
openaire +1 more source