Results 91 to 100 of about 123,777 (321)

Rehabilitation training improves nerve injuries by affecting Notch1 and SYN

Open Medicine, 2020
The aim of this study was to investigate the effects of rehabilitation training on Notch1 and synaptophysin (SYN) levels in brain tissues of rats with chronic cerebral ischemia.
Jing Mao, Yi Yang, Jinniu Zhang, Xiuli Kan, Jianxian Wu   +4 more
doaj   +1 more source

Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling [PDF]

, 2015
Notch signaling plays a crucial role in adult brain function such as synaptic plasticity, memory and olfaction. Several reports suggest an involvement of this pathway in neurodegenerative dementia. Yet, to date, the mechanism underlying Notch activity in
Alberi,, Astori,, Brai,, Fredj,, Lamy,, Marathe,, Perry,, Scotti,   +7 more
core   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]

, 1996
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C., Baltimore, David, Hasserjian, Robert P., Pear, Warren S., Scott, Martin L., Sklar, Jeffrey, Soffer, Benny   +6 more
core  

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Nature Cell Biology, 2009
Signalling through Notch receptors requires ligand-induced cleavage to release the intracellular domain, which acts as a transcriptional activator in the nucleus. Deregulated Notch1 signalling has been implicated in mammary tumorigenesis; however the mechanisms underlying Notch activation in breast cancer remain unclear.
Rustighi, Alessandra, Tiberi, Luca, Soldano, Alessia, Napoli, Marco, Nuciforo, Paolo, Rosato, Antonio, Kaplan, Fred, Capobianco, Anthony, Pece, Salvatore, Di Fiore, Pier Paolo, Del Sal, Giannino   +10 more
openaire   +7 more sources

Macrophage-released ADAMTS1 promotes muscle stem cell activation. [PDF]

, 2017
Coordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular ...
Aggarwal, Abhishek, Cho, Joonseok, Du, Hongqing, Feldman, Brian J, Mueller, Alisa A, Rando, Thomas A, Shih, Chung-Hsuan, Wosczyna, Michael N   +7 more
core   +2 more sources

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Exosomal miR-182-5p from breast cancer cells reprogram tumor-associated macrophages and promote triple-negative breast cancer progression by targeting Notch1 in macrophages

Archives of Medical Science
Introduction The regulatory role of miR-182 in breast cancer malignancy and macrophage reprogramming is well established. However, the mechanisms through which miR-182 overexpression in tumor cells influences macrophage polarization remain elusive ...
Hongtao Li, Jingjing Fan, Jing Ma, Lei Qiao, Tong Sha, Binlin Ma   +5 more
doaj   +1 more source

NOTCH1 mutation and its prognostic significance in Chinese chronic lymphocytic leukemia: a retrospective study of 317 cases

Cancer Medicine, 2018
The proto‐oncogene NOTCH1 is frequently mutated in around 10% of patients with chronic lymphocytic leukemia (CLL). This study analyzed NOTCH1 mutation status of 317 Chinese patients with CLL by Sanger sequencing. The frequencies of NOTCH1 mutation in the
Yixin Zou, Lei Fan, Yi Xia, Yi Miao, Wei Wu, Lei Cao, Jiazhu Wu, Huayuan Zhu, Chun Qiao, Li Wang, Wei Xu, Jianyong Li   +11 more
doaj   +1 more source