Results 91 to 100 of about 119,232 (259)

The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases

Exploration, EarlyView.
This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang   +3 more
wiley   +1 more source

NOTCH1 mutation and its prognostic significance in Chinese chronic lymphocytic leukemia: a retrospective study of 317 cases

Cancer Medicine, 2018
The proto‐oncogene NOTCH1 is frequently mutated in around 10% of patients with chronic lymphocytic leukemia (CLL). This study analyzed NOTCH1 mutation status of 317 Chinese patients with CLL by Sanger sequencing. The frequencies of NOTCH1 mutation in the
Yixin Zou, Lei Fan, Yi Xia, Yi Miao, Wei Wu, Lei Cao, Jiazhu Wu, Huayuan Zhu, Chun Qiao, Li Wang, Wei Xu, Jianyong Li   +11 more
doaj   +1 more source

ROLE OF THE NOTCH1 GENE IN FORMATION OF AORTIC ANEURYSM

Российский кардиологический журнал, 2018
Aim. To evaluate the impact of genetics in development of thoracic aneurysm in patients with tricuspid valve (TAV) and bicuspid aortic valve (BAV) based on the analysis and search for mutations in NOTCH1.Material and methods.
O. V. Irtyuga, O. A. Freilichman, D. S. Krivonosov, A. B. Malashicheva, S. I. Tarnovskaya, V. Е. Uspenskiy, M. L. Gordeev, O. P. Rotar, A. A. Kostareva, O. M. Moiseeva   +9 more
doaj   +1 more source

Prognostic Impact of Tumor Stage and Growth Pattern in Sinonasal Adenoid Cystic Carcinoma: A 15‐Year Population‐Based Study

Head &Neck, EarlyView.
ABSTRACT Background Sinonasal adenoid cystic carcinoma (AdCC) has a limited prognosis. This study assesses its incidence and prognostic factors in The Netherlands, focusing on histopathological features. Methods Adult patients diagnosed during 2008–2022 were retrieved through the Netherlands Cancer Registry and the Dutch Pathology Registry.
Lise J. van de Velde, Gerben E. Breimer, Lot A. Devriese, Mischa de Ridder, W. F. Julius Scheurleer, Weibel W. Braunius, Remco de Bree, Boukje A. C. van Dijk, Liza A. Hoveling, Johannes A. Rijken   +9 more
wiley   +1 more source

MODERN VIEWS ON THE GENE NOTCH1 MUTATIONS ROLE FOR AORTIC COARCTATION

Российский кардиологический журнал, 2014
Aim. By the observation of aortic coarctation victims families, to reveal factors predisposing to the disease development, and to evaluate the prevalence of NOTCH1 genes mutation/replacements in patients with this kind of defect.
T. N. Tatarinova, O. A. Freilichman, A. A. Kostareva, E. V. Grekhov, O. M. Moiseeva   +4 more
doaj   +1 more source

Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling [PDF]

, 2015
Notch signaling plays a crucial role in adult brain function such as synaptic plasticity, memory and olfaction. Several reports suggest an involvement of this pathway in neurodegenerative dementia. Yet, to date, the mechanism underlying Notch activity in
Alberi,, Astori,, Brai,, Fredj,, Lamy,, Marathe,, Perry,, Scotti,   +7 more
core   +1 more source

Different Pattern of Treatment Failure After Chemoradiation Between p16+ and p16− Patients Affected by Oropharyngeal Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Oropharyngeal cancer (OPC) exhibits distinct clinical behaviors according to HPV/p16 status and smoking exposure. While HPV‐positive OPC generally shows superior survival, differences in recurrence patterns remain unclear. Methods A retrospective multicenter analysis of 674 AJCC VII edition Stage III–IVa/b OPC patients treated with ...
Riccardo Gili, Paolo Bossi, Luca Lalli, Lisa Francesca Linda Licitra, Marta Maddalo, Almalina Bacigalupo, Liliana Belgioia, Jon Cacicedo, Nadia Facchinetti, Almudena Garcia Castano, Marc Oliva, Pierluigi Bonomo, Giuseppe Sanguineti, Pierfrancesco Franco, Athanassios Argiris, Amanda Psyrri, Ester Orlandi   +16 more
wiley   +1 more source

Notch1 Inhibition Exacerbates APAP-Induced Liver Injury via β-Catenin and Macrophage Polarization

Frontiers in Bioscience-Landmark
Background: Notch1 signaling regulates innate immune-mediated inflammation in acute liver injury (ALI). However, the precise mechanism by which Notch1 governs macrophage polarization during ALI remains poorly understood.
Tao Yang, Jingjing Dai, Junlan Zhou, Yuyun Shao, Xiao Wang, Jiaying Zhao, Jun Li, Ping Shi, Longfeng Jiang   +8 more
doaj   +1 more source

Rosuvastatin Improves Neurite Outgrowth of Cortical Neurons against Oxygen-Glucose Deprivation via Notch1-mediated Mitochondrial Biogenesis and Functional Improvement

Frontiers in Cellular Neuroscience, 2018
Neurogenesis, especially neurite outgrowth is an essential element of neuroplasticity after cerebral ischemic injury. Mitochondria may supply ATP to power fundamental developmental processes including neuroplasticity. Although rosuvastatin (RSV) displays
Weiliang He, Yingping Liu, Xiaochao Tian
doaj   +1 more source

Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow. [PDF]

, 2017
The functions of blood flow in the morphogenesis of mammalian arteries and veins are not well understood. We examined the development of the dorsal aorta (DA) and the cardinal vein (CV) in Ncx1 -/- mutants, which lack blood flow due to a deficiency in a ...
Beckouche, Nathan, Huang, Lawrence, Hwa, Jennifer J, Kram, Yoseph, Lindskog, Henrik, Wang, Rong A   +5 more
core   +2 more sources