Results 211 to 220 of about 118,516 (288)

Genetic depletion or pharmacological degradation of EZH2 attenuates renal fibrosis via suppressing Notch signaling. [PDF]

Clin Epigenetics
Yu C, Yao L, Du X, Yu J, Wang Y, Hou X, Shen F, Liu N, Zhuang S.   +8 more
europepmc   +1 more source

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, Volume 99, Issue 2, Page 341-355, February 2026.
[Color figure can be viewed at www.annalsofneurology.org] Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear.
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity. [PDF]

Front Immunol
Guo A, Su Z, Zhang E, Lin H, Zhong P, Xie Z, Zhan Q, Ye T, Sun Y.   +8 more
europepmc   +1 more source

Clinical impact of miR-223 expression in pediatric T-Cell lymphoblastic lymphoma [PDF]

, 2017
Basso, Giuseppe, Basso, Katia, Bonvini, Paolo, Carraro, Elisa, D'Amore, Emanuele S. G., De Vito, Rita, Farruggia, Piero, Lo Nigro, Luca, Lovisa, Federica, Mussolin, Lara, Pillon, Marta, Pomari, Elena, Primerano, Simona, Vinti, Luciana   +13 more
core   +1 more source

An Anoikis Resistance Phenotype Converged to Immune Dysfunction and Resistance to Immune Checkpoint Blockades in Gastric Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Gastric cancer (GC) has high global incidence and mortality, with most cases diagnosed at advanced stages. Immunotherapy, particularly immune checkpoint blockers (ICBs), has shown promise, but not all patients benefit. This study applied consensus clustering based on anoikis‐related genes (ANRGs) to classify GC into two subclusters.
Xing Cai, Jinru Yang, Fangyuan Zhang, Fuwang Xu, Yuan Fang, Zongbi Yi   +5 more
wiley   +1 more source

NOTCH1 and UPR signaling in embryonic heart development under maternal high-fat diet influence. [PDF]

Front Med (Lausanne)
Shi Y, Li B, Shi Q.
europepmc   +1 more source

Colorectal Cancer Organoid Model Reveals the Mechanisms of Irinotecan Resistance at Single‐Cell Resolution

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Objective Irinotecan, a standard therapeutic agent for metastatic colorectal cancer (mCRC), often faces significant limitations due to drug resistance, with treatment failure observed in approximately 30%–50% of patients, leading to poor clinical outcomes.
Yi Pan, Lin Chen, Yuqing Hu, Jie Chang, Xifeng Xu, ShuoChen Xu, YiWen Li, Jinlin Du, JianPing Wang, Wenxia Xu   +9 more
wiley   +1 more source

Designing a Multi-Epitope Vaccine Against NOTCH1 and NOTCH4: A Computational Approach for Triple-Negative Breast Cancer. [PDF]

Biomed Res Int
Teimoori P, Khatir K, Heidari M.
europepmc   +1 more source

The Vascular‐Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
This review synthesizes current evidence showing how vascular–immune cell crosstalk and microenvironmental cues shape pulmonary vascular remodeling in pulmonary hypertension. We provide an integrative perspective that positions disrupted cellular communication as a central driver of disease progression and a promising source of future therapeutic ...
Lola Navarro‐Llinares, Bertha García‐León, Laura de la Bastida‐Casero, Eduardo Oliver   +3 more
wiley   +1 more source

Disruption of Krox20-Notch1 signaling blocks meibomian gland development and homeostasis leading to dry eye disease. [PDF]

Nat Commun
Zhang Y, Tchegnon E, Ghotbi E, Chen Z, Moye SL, He Y, McKay RM, Le LQ.   +7 more
europepmc   +1 more source