Results 221 to 230 of about 119,232 (259)

The Tumor-to-Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma. [PDF]

Adv Sci (Weinh)
Wu C, Liu X, Gu L, Lian J, Wang Y, Cheng Y, Duan L, Huang G, Chen S, Zhao B, Liu S, Yang Y, Zheng S, Lu Z, Guo W, Hu J, Wang W, Zuo Z, Mai H, Tang L, Zhang S, Wen F, Hong X, Guo L.   +23 more
europepmc   +1 more source

Designing a Multi-Epitope Vaccine Against NOTCH1 and NOTCH4: A Computational Approach for Triple-Negative Breast Cancer. [PDF]

Biomed Res Int
Teimoori P, Khatir K, Heidari M.
europepmc   +1 more source

RETRACTION: Notch1 Protects Against Myocardial Ischaemia-Reperfusion Injury via Regulating Mitochondrial Fusion and Function. [PDF]

J Cell Mol Med
europepmc   +1 more source

Endothelial Notch1 Activity Facilitates Metastasis [PDF]

Cancer Cell, 2017
Endothelial cells (ECs) provide angiocrine factors orchestrating tumor progression. Here, we show that activated Notch1 receptors (N1ICD) are frequently observed in ECs of human carcinomas and melanoma, and in ECs of the pre-metastatic niche in mice. EC N1ICD expression in melanoma correlated with shorter progression-free survival.
Juan Rodriguez-Vita, Carolin Mogler, Elisa Espinet   +2 more
exaly   +3 more sources

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Targeting NOTCH1 in Hematopoietic Malignancy

Critical Reviews™ in Oncogenesis, 2011
NOTCH1 is a well-validated target in hematopoietic malignancy, with NOTCH1 activating mutations identified in more than 50% of T-cell acute lymphoblastic leukemias. Moreover, a recent report has identified NOTCH1 activating mutations in 12% of chronic lymphocytic leukemias.
ROTI, GIOVANNI, Stegmaier K.
openaire   +3 more sources

Notch1 promotes cancer spread

Science, 2017
Cancer Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of distant organs by tumors. Abnormally high levels of active Notch1 are found in blood vessels associated with advanced human cancers.
openaire   +2 more sources

p53 regulates thymic Notch1 activation

European Journal of Immunology, 2004
AbstractNotch is crucial for multiple stages of T cell development, including the CD4+CD8+ double positive (DP)/CD8+ single positive (SP) transition, but regulation of Notchactivation is not well understood. p53 regulates Presenilin1 (PS1) expression, and PS1 cleaves Notch, releasing its intracellular domain (NIC), leading to the expression of ...
Amy M, Laws, Barbara A, Osborne
openaire   +2 more sources

Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1

Biochemical and Biophysical Research Communications, 2011
Earlier studies demonstrated the involvement of the p300 histone acetyltransferase in Notch signaling but the precise mechanisms by which p300 might modulate Notch function remains to be investigated. In this study, we show that p300 acetylates Notch1 ICD in cell culture assay and in vitro, and conserved lysines located within the Notch C-terminal ...
Anita E, Popko-Scibor, Mikael J, Lindberg, Magnus L, Hansson, Teresa, Holmlund, Annika E, Wallberg   +4 more
openaire   +2 more sources