Results 231 to 240 of about 119,232 (259)

NOTCH1 modulates activity of DNA-PKcs

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2018
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) controls one of the most frequently used DNA repair pathways in a cell, the non-homologous end joining (NHEJ) pathway. However, the exact role of DNA-PKcs in NHEJ remains poorly defined. Here we show that NOTCH1 attenuates DNA-PKcs-mediated autophosphorylation, as well as the phosphorylation of ...
Adamowicz M, d'Adda di Fagagna F, Vermezovic J   +2 more
openaire   +2 more sources

Notch1 regulates hepatic thrombopoietin production

Blood
Abstract Notch signaling regulates cell-fate decisions in several developmental processes and cell functions. However, the role of Notch in hepatic thrombopoietin (TPO) production remains unclear. We noted thrombocytopenia in mice with hepatic Notch1 deficiency and so investigated TPO production and other features ...
Yueyue Sun, Huan Tong, Xiang Chu, Yingying Li, Jie Zhang, Yangyang Ding, Sixuan Zhang, Xiang Gui, Chong Chen, Mengdi Xu, Zhenyu Li, Elizabeth E. Gardiner, Robert K. Andrews, Lingyu Zeng, Kailin Xu, Jianlin Qiao   +15 more
openaire   +2 more sources

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response

Science Signaling, 2015
Methylation of the active Notch cleavage product promotes its degradation to produce short periods of Notch signaling necessary for proper development.
K. Hein, G. Mittler, W. Cizelsky, M. Kuhl, F. Ferrante, R. Liefke, I. M. Berger, S. Just, J. E. Strang, H. A. Kestler, F. Oswald, T. Borggr   +11 more
openaire   +4 more sources

Notch1and the activated NOTCH1 intracellular domain are expressed in differentiated trophoblast cells

Cell Biology International, 2011
The Notch signalling pathway regulates proliferation, cell death and cell type specification that is critical for organogenesis. Mouse models carrying mutations in the Notch signalling pathway display defects in development of the placenta, suggesting that this pathway is required for placental development.
Didem Pelin, Sarikaya, Loydie Anne, Jerome-Majewska   +1 more
openaire   +2 more sources

Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1

Archives of Gynecology and Obstetrics, 2015
Notch signalings are regulated multiple cellular processes during cancer progression. We aimed to investigate the significance and prognostic value of expression of Notch1 and JAG1 in cervical cancer to determine whether they could serve as prognostic predictors.The expression of Notch1/JAGD1 was investigated by real-time PCR, western blot assay and ...
Nasser Ghaly, Yousif, Alaa Muhammad, Sadiq, Maitham G, Yousif, Rihab H, Al-Mudhafar, Jinan J, Al-Baghdadi, Najah, Hadi   +5 more
openaire   +2 more sources

“Cryptic” Notch1 messages induce T-ALL

Blood, 2010
In this issue of Blond, 2 articles define a new class of somatic mutations that allow transcription of oncogenic Notch 1 from cryptic internal promoters.
openaire   +2 more sources

Notch1

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth

Nature Genetics, 2023
Stefan Dentro, Michael Hall, Swee Hoe Ong   +2 more
exaly  

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

Cancer Cell, 2009
Shadmehr Demehri, Raphael Kopan
exaly  

USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia

Signal Transduction and Targeted Therapy, 2018
Huizhuang Shan, Yu-Ting Dai, Hu Lei
exaly