Results 61 to 70 of about 119,232 (259)

Capture and Culture of Circulating Tumor Cells Using a Biodegradable 3D Scaffold for Patient‐Derived Xenograft Construction

Advanced Science, EarlyView.
A self‐supporting, biocompatible, and biodegradable 3D cellulose scaffold has been developed for efficient isolation and in situ expansion of circulating tumor cells (CTCs) from patient blood. Subsequently, the 3D cellulose scaffold with cultured CTCs is directly implanted into immunodeficient mice for constructing patient CTC‐derived xenograft (CDX ...
Yi‐Ke Wang, Ming Wang, Min Liu, Yi‐Jing Chen, Li‐Li Xu, Jin‐Ping Zhou, Fu‐Bing Wang, Shi‐Bo Cheng, Min Xie, Wei‐Hua Huang   +9 more
wiley   +1 more source

RS13290979 POLYMORPHISM WITHIN NOTCH1 GENE IS ASSOCIATED WITH SEVERE BIOPROSTHETIC MITRAL VALVE CALCIFICATION

Фундаментальная и клиническая медицина, 2018
Aim. Bioprosthetic mitral valves frequently undergo severe calcification causing bioprosthetic valve failure, an urgent problem in cardiovascular surgery.
ANASTASIA V. Ponasenko, ANTON G. Kutikhin, MARIA V. Khutornaya, NATALIA V. Rutkovskaya, ANNA V. Tsepokina, NATALIA V. Kondyukova, ARSENIY E. Yuzhalin, LEONID S. Barbarash   +7 more
doaj  

Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia

Haematologica, 2009
Background NOTCH1 mutations have been associated with a favorable outcome in pediatric acute T-lymphoblastic leukemia. However, the results of studies on the prognostic significance of NOTCH1 mutations in adult T-lymphoblastic leukemia remain ...
Claudia D. Baldus, Julia Thibaut, Nicola Goekbuget, Andrea Stroux, Cornelia Schlee, Max Mossner, Thomas Burmeister, Stefan Schwartz, Clara D. Bloomfield, Dieter Hoelzer, Eckhard Thiel, Wolf-Karsten Hofmann   +11 more
doaj   +1 more source

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

LINC00612/miR-31-5p/Notch1 Axis Regulates Apoptosis, Inflammation, and Oxidative Stress in Human Pulmonary Microvascular Endothelial Cells Induced by Cigarette Smoke Extract

International Journal of COPD, 2020
Jun Luo,1,* Li Li,2,* Die Hu,2 Xian Zhang1 1Department of Laboratory Medicine, Chengdu Second People’s Hospital, Chengdu 610000, Sichuan, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Dujiangyan People ...
Luo J, Li L, Hu D, Zhang X
doaj  

Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy

Journal of Experimental & Clinical Cancer Research, 2019
Background NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5–10% of cases and are associated with significantly shorter survival rates.
Elisabeth Silkenstedt, Fabian Arenas, Berta Colom-Sanmartí, Sílvia Xargay-Torrent, Morihiro Higashi, Ariadna Giró, Vanina Rodriguez, Patricia Fuentes, Walter E. Aulitzky, Heiko van der Kuip, Sílvia Beà, Maria L. Toribio, Elias Campo, Mònica López-Guerra, Dolors Colomer   +14 more
doaj   +1 more source

Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells [PDF]

, 2018
Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands.
Agnusdei, Valentina, Amadori, Alberto, Ciminale, Vincenzo, Ciribilli, Yari, Fossati, Gianluca, Ghisi, Margherita, Indraccolo, Stefano, Minuzzo, Sonia, Pezz\ue8, Laura, Pilotto, Giorgia, Pinazza, Marica, Venturoli, Carolina   +11 more
core   +3 more sources

Loss of Notch1-dependent p21^Waf1/Cip1expression influences the Notch1 outcome in tumorigenesis [PDF]

Cell Cycle, 2014
Notch signaling plays a complex role in carcinogenesis, and its signaling pathway has both tumor-suppressor and oncogenic components. In this study we investigated the effects of reactive oxygen species (ROS) on Notch1 signaling outcome in keratinocyte biology.
CIALFI, Samantha, PALERMO, ROCCO, MANCA, SONIA, DE BLASIO, CARLO, VARGAS ROMERO, PAULA ESTEFANIA, CHECQUOLO, Saula, BELLAVIA, Diana, UCCELLETTI, Daniela, SALIOLA, Michele, Angelo, D’Alessandro, Lello, Zolla, GULINO, Alberto, SCREPANTI, Isabella, TALORA, Claudio   +13 more
openaire   +3 more sources

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)

BMC Neurology, 2018
Background Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However, the role of Notch1 in glioma EMT
Jianlong Li, Qingbin Li, Lin Lin, Rui Wang, Lingchao Chen, Wenzhong Du, Chuanlu Jiang, Ruiyan Li   +7 more
doaj   +1 more source