Results 81 to 90 of about 123,777 (321)

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

PLoS ONE, 2010
Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer as well as tumor angiogenesis, making Notch1 a potential therapeutic target.Here we report the in vitro ...
Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E, Arnold, Beth A, Toner, Timothy J, Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T, Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frédéric, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R, Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N, Franlin, Laura L, Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J, Audoly, Laurent P, Aster, Jon C, Blacklow, Stephen C, Huber, Hans E   +29 more
openaire   +6 more sources

Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation [PDF]

Leukemia, 2014
Alterations in Notch signaling are involved in chronic lymphocytic leukemia (CLL) pathogenesis, a hematological disease characterized by the accumulation of CD19+/CD5+ B cells resistant to apoptosis. We previously reported that constitutive Notch1/2 activation contributes to apoptosis resistance of CLL cells.1 Furthermore, a NOTCH1 PEST domain mutation,
De Falco F, Sabatini R, Falzetti F, DI IANNI, MAURO, Sportoletti P, Baldoni S, Del Papa B, Screpanti I, Marconi P, Rosati E.   +9 more
openaire   +2 more sources

LncRNA DCST1-AS1 Was Upregulated in Endometrial Carcinoma and May Sponge miR-92a-3p to Upregulate Notch1

Cancer Management and Research, 2020
Jieqi Ke, Zheng Shen, Weiping Hu, Min Li, Yangyang Shi, Zhen Xie, Dabao Wu Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui
Ke J, Shen Z, Hu W, Li M, Shi Y, Xie Z, Wu D   +6 more
doaj  

An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Aberrant activation of Notch signaling has been causally linked to the metastasis of hepatocellular carcinoma (HCC), however the underlying molecular mechanisms are still poorly understood.
Lei Zhang, Jiewei Chen, Juanjuan Yong, Liang Qiao, Leibo Xu, Chao Liu   +5 more
doaj   +1 more source

Clinical Value of Differential Expression of Pim1 and Notch1 During Carcinogenesis of Breast Cancer

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the differential expression levels of Pim1 and Notch1 in breast tissues and their clinical and prognostic significance. Methods qRT-PCR, immunohistochemistry and databases were used to detect the mRNA and protein levels of Pim1 ...
XIONG Shishuang, CHEN Xiaowen, MU Ya'nan, ZHANG Derui, JIANG Jinfang, LI Jun, CAO Yuwen   +6 more
doaj   +1 more source

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery

, 2010
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail.
Amberger, Bader, Bader, Bauer-Mehren, Becker, Behar, Berger, Berglund, Beyer, Bhattacharyya, Borisov, Boyle, Chaudhuri, Chen, Csaba Böde, Cusick, Davidov, Dennis, Drysdale, Dávid Fazekas, Fabbro, Frame, Freeman, Friedland, Gao, Harris, Hoffmann, Hopkins, Hornberg, Hunter, Illés J. Farkas, Joshi-Tope, Kandasamy, Katalin Lenti, Kholodenko, Klein, Komarova, Korcsmaros, Levine, Li, Liu, Lu, Luo, Morioka, Máté S. Szalay, O'Brien, Ogata, Papin, Petra Rovó, Pires-daSilva, Péter Csermely, Rhodes, Rogers, Sakharkar, Sergina, Stelling, Szathmary, Tamás Korcsmáros, Taniguchi, Tibor Vellai, Tortora, Urban, Wang, Xia, Yildirim, Zoltán Spiró   +65 more
core   +1 more source

Core binding factors are necessary for natural killer cell development, and cooperate with Notch signaling during T cell specification [PDF]

, 2008
CBF{beta} is the non-DNA binding subunit of the core binding factors (CBFs). Mice with reduced CBF{beta} levels display profound, early defects in T but not B cell development.
Adler, Agosti, Aster, Balciunaite, Barton, Bhandoola, Bories, Burns, Cai, Carlyle, Carlyle, Carotta, Dallas, Davis, de Bruijn, Deftos, DeHart, Di Santo, Douagi, Egawa, Egawa, Ellen V. Rothenberg, Eyquem, Franco, Georgopoulos, Gomez-Lozano, Growney, Han, Heemskerk, Held, Ichikawa, Ikawa, Ivan Maillard, Kee, Kovanen, Krutzik, Kumano, Lacorazza, Lebestky, Lebestky, Maillard, Maillard, Massa, Masuda, McLarren, Moore, Moriggl, Mukouyama, Muthusamy, Nakagawa, Nancy A. Speck, North, Ohno, Okamura, Ono, Pear, Peschon, Pui, Radtke, Robert-Moreno, Rodewald, Rothenberg, Saleh, Sambandam, Sankhamala Chakraborti, Schmitt, Schmitt, Taghon, Talebian, Taniuchi, Van De Wiele, Vosshenrich, Wang, Wilson, Wilson, Yalin Guo, Yokota   +76 more
core   +3 more sources

Up-regulation of MiR-146b-5p Inhibits Fibrotic Lung Pericytes via Inactivation of the Notch1/PDGFRβ/ROCK1 Pathway [PDF]

, 2022
Wei Shuai, Qian Chen, Xu Zhou
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source