Results 91 to 100 of about 15,431 (206)

Novel mechanism of resistance to targeted therapies in lung cancer

Molecular & Cellular Oncology, 2019
We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β ...
Walter Wang, David P. Carbone, Rajeswara Rao Arasada   +2 more
doaj   +1 more source

Clinicopathological characteristics of osteosarcoma and prognostic significance of Notch receptors and ligands expression: analysis of 70 cases

Di-san junyi daxue xuebao, 2019
Objective To investigate the clinicopathological features of osteosarcoma and the prognostic significance of the expression of Notch receptors and ligands.
TANG Xuefeng, ZENG Ying, WANG Yali
doaj   +1 more source

Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics

MedComm, Volume 7, Issue 3, March 2026.
In HOMAGE, 276 plasma proteins were profiled using Olink panels. Machine learning algorithms identified galectin‐9 (GAL9), thrombospondin‐2 (THBS2), and NT‐proBNP as predictors of changes in procollagen type I C‐terminal propeptide (PICP) after spironolactone treatment.
Susana Ravassa, Nicolas Girerd, Frank Edelman, Begoña López, João Pedro Ferreira, Daniela Zurkan, Gorka San José, Iñigo Latasa, Pierpaolo Pellicori, Franco Cosmi, Johannes Petutschnigg, Stephane Heymans, Hans‐Peter Brunner‐La Rocca, Burkert Pieske, Christian Delles, Andrew L. Clark, Javier Díez, Faiez Zannad, John G. F. Cleland, Arantxa González, the HOMAGE Trial Committees and Investigators   +20 more
wiley   +1 more source

Notch3 enhances the synergistic effect of all-trans retinoic acid and calcipotriol in pancreatic stellate cell activation

Journal of Translational Medicine
Background Chronic pancreatitis (CP) is characterized by progressive fibrosis and the activation of pancreatic stellate cells (PSCs). As major producers of collagen-I and fibronectin, PSCs play important roles in pancreatic fibrosis, but few studies have
Zheng Lian, Wei-hong Du, Paizi-guli Tusup-han, Yu-xiang Zhang   +3 more
doaj   +1 more source

A Brain‐Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF‐β1/PI3K–AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumour, associated with a dismal prognosis and an urgent need for innovative therapeutic strategies. To address this challenge, our group developed DMC‐GF, a novel brain‐targeted curcumin analog engineered to enhance blood–brain barrier permeability by blocking metabolic sites and ...
Zijian Han, Xuetao Li, Yang Zhu, Zhimin Wang, Yingbo Hou, Huiling Tao, Meng Ma, Xiangtong Xie, HaiYang Zhang   +8 more
wiley   +1 more source

Proteomic insights into the invasiveness and tumor progression of non‐functioning pituitary adenomas: A scoping review

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Nonfunctioning pituitary adenomas (NFPAs) are common intracranial tumors that, despite being histologically benign, can exhibit invasive growth, as well as postoperative tumor progression. Surgical resection is the primary treatment of choice; however, residual tumor tissue is frequently observed, with between 30% and 50% of these cases ...
Thomas Skoglund, Linus Köster, Annika Thorsell, Oskar Ragnarsson, Gudmundur Johannsson, Tobias Hallén   +5 more
wiley   +1 more source

Omega-3 fatty acids impair miR-1-3p-dependent Notch3 down-regulation and alleviate sepsis-induced intestinal injury [PDF]

, 2022
You-Lian Chen, Yinjing Xie, Zhenmi Liu, Weibu Chen, Ru Zhang, Hong-Xing Ye, Wei Wang, Xueyan Liu, Huaisheng Chen   +8 more
openalex   +1 more source

The role of NOTCH3 variants in Alzheimer's disease and subcortical vascular dementia in the Chinese population

, 2021
Lina Guo, Bin Jiao, Xinxin Liao, Xuewen Xiao, Weiwei Zhang, Zhenhua Yuan, Xixi Liu, Lu Zhou, Xin Wang, Yuan Zhu, Qijie Yang, Junling Wang, Beisha Tang, Lu Shen   +13 more
openalex   +1 more source

Microbleed clustering in thalamus sign in CADASIL patients with NOTCH3 R75P mutation [PDF]

, 2023
Jun Takei, Yujiro Higuchi, Masahiro Ando, Akiko Yoshimura, Jun‐Hui Yuan, Natsumi Fujisaki, Takashi Tokashiki, Naomi Kanzato, Manabu Jonosono, Takeshi Sueyoshi, Naoaki Kanda, Hideki Matsuoka, Ryuichi Okubo, Masahito Suehara, Eiji Matsuura, Hiroshi Takashima   +15 more
openalex   +1 more source

Response to Letter Regarding Article, “The Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Scale. A Screening Tool to Select Patients for NOTCH3 Gene Analysis” [PDF]

, 2013
Francesca Pescini, Serena Nannucci, Leonardo Pantoni   +2 more
openalex   +1 more source