Results 31 to 40 of about 15,431 (206)

Vascular NOTCH3 Deposition Load: Association With <i>NOTCH3</i> Genotype and CADASIL Disease Severity. [PDF]

Neurol Genet
Cheng YW, Chen CH, Chao CC, Chen YF, Jeng JS, Tang SC, Hsieh ST.   +6 more
europepmc   +2 more sources

Enhancer remodeling activates NOTCH3 signaling to confer chemoresistance in advanced nasopharyngeal carcinoma

Cell Death and Disease, 2023
Acquired resistance to chemotherapy is one of the major causes of mortality in advanced nasopharyngeal carcinoma (NPC). However, effective strategies are limited and the underlying molecular mechanisms remain elusive.
Lizhen Liu, Peng Deng, Sailan Liu, Jing Han Hong, Rong Xiao, Peiyong Guan, Yali Wang, Peili Wang, Jiuping Gao, Jinghong Chen, Yichen Sun, Jianfeng Chen, Hai-Qiang Mai, Jing Tan   +13 more
doaj   +1 more source

Notch3 and the Notch3‐upregulated RNA‐binding protein HuD regulate Ikaros alternative splicing [PDF]

The EMBO Journal, 2007
Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell receptor (pre-TCR) signaling.
BELLAVIA, Diana, Marco Mecarozzi, CAMPESE, Antonio Francesco, GRAZIOLI, PAOLA, TALORA, Claudio, FRATI, Luigi, GULINO, Alberto, SCREPANTI, Isabella   +7 more
openaire   +3 more sources

Comparison of Longitudinal Changes of Cerebral Small Vessel Disease Markers and Cognitive Function Between Subcortical Vascular Mild Cognitive Impairment With and Without NOTCH3 Variant: A 5-Year Follow-Up Study

Frontiers in Neurology, 2021
No study yet has compared the longitudinal course and prognosis between subcortical vascular cognitive impairment patients with and without genetic component.
Cindy W. Yoon, Young-Eun Kim, Hee Jin Kim, Chang-Seok Ki, Hyejoo Lee, Joung-Ho Rha, Duk L. Na, Sang Won Seo   +7 more
doaj   +1 more source

Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells

Cells, 2022
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of some patients with
Weiling Chen, Yongqu Zhang, Ronghui Li, Wenhe Huang, Xiaolong Wei, De Zeng, Yuanke Liang, Yunzhu Zeng, Min Chen, Lixin Zhang, Wenliang Gao, Yuanyuan Zhu, Yaochen Li, Guojun Zhang   +13 more
doaj   +1 more source

Lysosome-dependent degradation of Notch3 [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Notch signaling plays an essential role in diverse biological processes during development and in pathogenesis of diseases ranging from cancer to cerebrovascular disorders. Precise regulation of Notch signaling is essential for normal function and requires both timely activation and inactivation of the intracellular domain (ICD) of Notch receptors.
Lijun, Jia, Genggeng, Yu, Yanmei, Zhang, Michael M, Wang   +3 more
openaire   +2 more sources

Naturally occurring NOTCH3 exon skipping attenuates NOTCH3 protein aggregation and disease severity in CADASIL patients [PDF]

Human Molecular Genetics, 2020
Abstract CADASIL is a vascular protein aggregation disorder caused by cysteine-altering NOTCH3 variants, leading to mid-adult-onset stroke and dementia. Here, we report individuals with a cysteine-altering NOTCH3 variant that induces exon 9 skipping, mimicking therapeutic NOTCH3 cysteine correction.
Gido Gravesteijn, Johannes G Dauwerse, Maurice Overzier, Gwendolyn Brouwer, Ingrid Hegeman, Aat A Mulder, Frank Baas, Mark C Kruit, Gisela M Terwindt, Sjoerd G van Duinen, Carolina R Jost, Annemieke Aartsma-Rus, Saskia A J Lesnik Oberstein, Julie W Rutten   +13 more
openaire   +4 more sources

The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. [PDF]

PLoS ONE, 2013
Wnt and Notch signaling pathways both play essential roles and interact closely in development and carcinogenesis, but their interaction in non-small-cell lung cancer (NSCLC) is poorly unknown.
Chunyan Li, Siyang Zhang, Yao Lu, Ying Zhang, Enhua Wang, Zeshi Cui   +5 more
doaj   +1 more source

Thrombospondin 2 Potentiates Notch3/Jagged1 Signaling [PDF]

Journal of Biological Chemistry, 2009
Extracellular thrombospondins (TSP or THBS) and the Notch family of transmembrane receptors share a role in multiple, overlapping cellular functions and participate in developmental signaling and pathological reactions to tissue injury. We demonstrate that TSP2, but not TSP1, enhances the potency of Notch3 signal transduction. In addition, TSP2 reduces
He, Meng, Xiaojie, Zhang, Kurt D, Hankenson, Michael M, Wang   +3 more
openaire   +2 more sources

Notch3 Pathway Alterations in Ovarian Cancer [PDF]

Cancer Research, 2014
Abstract The Notch pathway plays an important role in the growth of high-grade serous ovarian (HGS-OvCa) and other cancers, but its clinical and biologic mechanisms are not well understood. Here, we found that the Notch pathway alterations are prevalent and significantly related to poor clinical outcome in patients with ovarian cancer.
Hu, Wei, Liu, Tao, Ivan, Cristina, Sun, Yunjie, Huang, Jie, Mangala, Lingegowda S., Miyake, Takahito, Dalton, Heather J., Pradeep, Sunila, Rupaimoole, Rajesh, Previs, Rebecca A., Han, Hee Dong, Bottsford-Miller, Justin, Zand, Behrouz, Kang, Yu, Pecot, Chad V., Nick, Alpa M., Wu, Sherry Y., Lee, Ju-Seog, Sehgal, Vasudha, Ram, Prahlad, Liu, Jinsong, Tucker, Susan L., Lopez-Berestein, Gabriel, Baggerly, Keith A., Coleman, Robert L., Sood, Anil K.   +26 more
openaire   +3 more sources