Results 41 to 50 of about 15,431 (206)

NOTCH3 Variants in Patients with Suspected CADASIL

Annals of Indian Academy of Neurology, 2023
Abstract Background: Cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) is the most common hereditary form of cerebral small vessel disease. It is clinically, radiologically, and genetically heterogeneous and is caused by NOTCH3 mutations.
Taskapilioglu, Ozlem, Kabay, Sibel C., Tepe, Nermin, Ali, Asuman, Sivaci, Ali O., Seferoglu, Meral, Topak, Ali, Gorukmez, Ozlem, Gorukmez, Orhan   +8 more
openaire   +5 more sources

Notch 3 Protein, not its Gene Polymorphism, is Associated with the Chemotherapy Response and Prognosis of Advanced NSCLC Patients

Cellular Physiology and Biochemistry, 2014
Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC).
Chunlei Shi, Jialin Qian, Meili Ma, Yanwei Zhang, Baohui Han   +4 more
doaj   +1 more source

Patient with CADASIL – a diagnostic challenge

Annales Academiae Medicae Silesiensis, 2023
INTRODUCTION: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetically determined and hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene.
Julia Węgrzynek, Agnieszka Tomaszewska, Angelika Wawrzkiewicz-Witkowska   +2 more
doaj   +1 more source

RANBP1 Regulates NOTCH3-Mediated Autophagy in High Glucose-Induced Vascular Smooth Muscle Cells

Frontiers in Bioscience-Landmark
Background: Vascular smooth muscle cells(VSMCs) phenotypic switching under hyperglycemic conditions accelerates atherosclerotic progression.
Zhong-jiao Xu, Jian Xu, Wen-jing Lei, Xiang Wang, Qi-lin Zou, Lin-chun Lv, Chong Liu, Wu-ming Hu, Yi-jia Xiang, Jia-yi Shen, Tie-min Wei, Chun-lai Zeng   +11 more
doaj   +1 more source

The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation [PDF]

Acta Neuropathologica Communications, 2015
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, leading to toxic NOTCH3 protein accumulation in the small- to medium sized arterioles.
Rutten, J.W., Klever, R.R., Hegeman, I.M., Poole, D.S., Dauwerse, H.G., Broos, L.A.M., Breukel, C., Aartsma-Rus, A.M., Verbeek, J.S., Weerd, L. van der, Duinen, S.G. van, Maagdenberg, A.M.J.M. van den, Oberstein, S.A.J.L.   +12 more
openaire   +3 more sources

The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients

Open Medicine, 2022
ASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and NOTCH3 and their relationships on prognosis.
Su Li-ping, Ji Min, Liu Li, Sang Wei, Xue Jing, Wang Bo, Pu Hong-Wei, Zhang Wei   +7 more
doaj   +1 more source

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin-FAK Signaling Activation. [PDF]

Cancer Sci
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Yoshida J, Ohishi T, Momose I, Ohba SI, Kurosawa K, Harakawa A, Inoue H, Senoo M, Tatsuda D, Abe H, Masamune A, Kawada M.   +11 more
europepmc   +2 more sources

Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis

Medicina, 2019
Background and objectives: NOTCH3 gene variations play a significant role in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Loo Keat Wei, Lyn R. Griffiths, Irene Looi, Cheah Wee Kooi   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Notch3 drives development and progression of cholangiocarcinoma [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Clinical outcomes in cholangiocarcinoma (CC) are poor; few patients are candidates for curative resection, and palliative chemotherapy produces only modest effects on survival. With an increasing incidence, new targets are urgently needed.
Guest, Rachel V., Boulter, Luke, Dwyer, Benjamin J., Kendall, Timothy J., Man, Tak-Yung, Minnis-Lyons, Sarah E., Lu, Wei-Yu, Robson, Andrew J., Gonzalez, Sofia Ferreira, Raven, Alexander, Wojtacha, Davina, Morton, Jennifer P., Komuta, Mina, Roskams, Tania, Wigmore, Stephen J., Sansom, Owen J., Forbes, Stuart J.   +16 more
openaire   +5 more sources