Results 71 to 80 of about 15,431 (206)

NOTCH3 signalling controls human trophoblast stem cell expansion and differentiation [PDF]

, 2023
Bianca Dietrich, Victoria Kunihs, Andreas Ian Lackner, Gudrun Meinhardt, Bon‐Kyoung Koo, Jürgen Pollheimer, Sandra Haider, Martin Knöfler   +7 more
openalex   +1 more source

The Role of Notch3 in Cancer [PDF]

The Oncologist, 2018
Abstract The Notch family is a highly conserved gene group that regulates cell-cell interaction, embryogenesis, and tissue commitment. This review article focuses on the third Notch family subtype, Notch3. Regulation via Notch3 signaling was first implicated in vasculogenesis.
Zviadi, Aburjania, Samuel, Jang, Jason, Whitt, Renata, Jaskula-Stzul, Herbert, Chen, J Bart, Rose   +5 more
openaire   +2 more sources

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Supplementary Figure S3 from LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem–like Cells

, 2023
Chungang Liu, Limei Liu, Xuejiao Chen, Jiamin Cheng, Heng Zhang, Chengcheng Zhang, Juanjuan Shan, Junjie Shen, Cheng Qian   +8 more
openalex   +2 more sources

CADASIL mutations enhance spontaneous multimerization of NOTCH3 [PDF]

Human Molecular Genetics, 2009
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cause of stroke and vascular dementia. Disease-causing mutations invariably affect cysteine residues within epidermal growth factor-like repeat domains in the extracellular domain of the NOTCH3 receptor (N3(ECD)).
Christian, Opherk, Marco, Duering, Nils, Peters, Anna, Karpinska, Stefanie, Rosner, Elisabeth, Schneider, Benedikt, Bader, Armin, Giese, Martin, Dichgans   +8 more
openaire   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

NOTCH3 promotes malignant progression of bladder cancer by directly regulating SPP1 and activating PI3K/AKT pathway

Cell Death and Disease
The biological role and precise molecular mechanisms of Notch receptor 3 (NOTCH3) in the malignant progression of bladder cancer (BLCA) remain unclear. In this study, we found that NOTCH3 was significantly upregulated and associated with poor prognosis ...
Changxue Liu, Huaixi Ge, Chengquan Shen, Ding Hu, Xinzhao Zhao, Ruize Qin, Yonghua Wang   +6 more
doaj   +1 more source

Glycerophosphoinositol modulates FGA and NOTCH3 in exercise-induced muscle adaptation and colon cancer progression

Frontiers in Pharmacology
ObjectivesFibroleukin (FGA) and NOTCH3 are vital in both exercise-induced muscle adaptation and colon adenocarcinoma (COAD) progression. This study aims to elucidate the roles of FGA and NOTCH3 in phenotypic variations of striated muscle induced by ...
Hongbiao Luo, Hongbiao Luo, Wei Luo, Ning Ding, Huimin Zhu, Jiahui Lai, Qingzhu Tang, Yongheng He, Yongheng He   +8 more
doaj   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Targeting the Notch receptor dimerization domain to inhibit Notch signalling—A new avenue of therapeutics

The FEBS Journal, EarlyView.
Notch signalling is an evolutionarily conserved signalling pathway that directs cell growth and differentiation across multiple tissue types, and its regulation must be controlled across the lifespan. Aberrant Notch signalling due to genetic mutations that occur within the negative regulatory region of the Notch 1 gene is linked to the development of ...
Gerard F Hoyne
wiley   +1 more source