Results 21 to 30 of about 2,529,505 (194)

Notch3 is an asymmetric gene and a modifier of heart looping defects in Nodal mouse mutants.

PLoS Biology
The TGFβ secreted factor NODAL is a major left determinant required for the asymmetric morphogenesis of visceral organs, including the heart. Yet, when this signaling is absent, shape asymmetry, for example of the embryonic heart loop, is not fully ...
Tobias Holm Bønnelykke, Marie-Amandine Chabry, Emeline Perthame, Gregor Dombrowsky, Felix Berger, Sven Dittrich, Marc-Phillip Hitz, Audrey Desgrange, Sigolène M Meilhac   +8 more
doaj   +2 more sources

Defining NOTCH3 Target Genes in Ovarian Cancer [PDF]

Cancer Research, 2012
Abstract NOTCH3 gene amplification plays an important role in the progression of many ovarian and breast cancers, but the targets of NOTCH3 signaling are unclear. Here, we report the use of an integrated systems biology approach to identify direct target genes for NOTCH3.
Xu, Chen, Michelle M, Thiaville, Li, Chen, Alexander, Stoeck, Jianhua, Xuan, Min, Gao, Ie-Ming, Shih, Tian-Li, Wang   +7 more
openaire   +2 more sources

Notch3 gene polymorphism and ischaemic cerebrovascular disease [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2002
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a type of hereditary stroke and dementia. More than 90% of patients with CADASIL have mutations in the Notch3 gene. All mutations either create or destroy a cysteine residue in the epidermal growth factor-like repeats. In addition, five polymorphisms,
D, Ito, N, Tanahashi, M, Murata, H, Sato, I, Saito, K, Watanabe, Y, Fukuuchi   +6 more
openaire   +2 more sources

Comparison of Longitudinal Changes of Cerebral Small Vessel Disease Markers and Cognitive Function Between Subcortical Vascular Mild Cognitive Impairment With and Without NOTCH3 Variant: A 5-Year Follow-Up Study

Frontiers in Neurology, 2021
No study yet has compared the longitudinal course and prognosis between subcortical vascular cognitive impairment patients with and without genetic component.
Cindy W. Yoon, Young-Eun Kim, Hee Jin Kim, Chang-Seok Ki, Hyejoo Lee, Joung-Ho Rha, Duk L. Na, Sang Won Seo   +7 more
doaj   +1 more source

Notch 3 Protein, not its Gene Polymorphism, is Associated with the Chemotherapy Response and Prognosis of Advanced NSCLC Patients

Cellular Physiology and Biochemistry, 2014
Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC).
Chunlei Shi, Jialin Qian, Meili Ma, Yanwei Zhang, Baohui Han   +4 more
doaj   +1 more source

CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]

, 2002
Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core   +1 more source

notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish

Disease Models & Mechanisms, 2013
SUMMARY Mutations in the human NOTCH3 gene cause CADASIL syndrome (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).
Andreas Zaucker, Sara Mercurio, Nitzan Sternheim, William S. Talbot, Florence L. Marlow   +4 more
doaj   +1 more source

NOTCH3 Variants and Genotype-Phenotype Features in Chinese CADASIL Patients

Frontiers in Genetics, 2021
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease caused by mutations in the NOTCH3 gene.
Yacen Hu, Yacen Hu, Qiying Sun, Qiying Sun, Yafang Zhou, Yafang Zhou, Fang Yi, Fang Yi, Haiyun Tang, Lingyan Yao, Lingyan Yao, Yun Tian, Yun Tian, Nina Xie, Nina Xie, Mengchuan Luo, Mengchuan Luo, Zhiqin Wang, Zhiqin Wang, Xinxin Liao, Xinxin Liao, Hongwei Xu, Hongwei Xu, Lin Zhou, Lin Zhou   +24 more
doaj   +1 more source

Two novel mutations and a previously unreported intronic polymorphism in the NOTCH3 gene [PDF]

, 2012
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease of small vessel caused by mutations in the NOTCH3 gene (NCBI Gene ID: 4854) located on chromosome 19p13.1.
Griffiths, L.R., Menon, S., Maksemous, N, Roy, Bishakha, Smith, Robert, Smith, R.A., Griffiths, Lyn, Maksemous, N., Davies, G., Roy, B, Davis, Gail, Smith, RA, Griffiths, LR, Menon, S, Roy, B., Davies, G, Menon, Saras, Maksemous, Neven   +17 more
core   +1 more source

Naturally occurring NOTCH3 exon skipping attenuates NOTCH3 protein aggregation and disease severity in CADASIL patients [PDF]

, 2020
CADASIL is a vascular protein aggregation disorder caused by cysteine-altering NOTCH3 variants, leading to mid-adult-onset stroke and dementia. Here, we report individuals with a cysteine-altering NOTCH3 variant that induces exon 9 skipping, mimicking ...
Terwindt, Gisela M., Jost, Carolina R., Rutten, Julie W., Lesnik Oberstein, Saskia A. J., Dauwerse, Johannes G., Brouwer, Gwendolyn, Kruit, Mark C., Gravesteijn, Gido, Baas, Frank, Aartsma-Rus, Annemieke, van Duinen, Sjoerd G., Hegeman, Ingrid, Overzier, Maurice, Mulder, Aat A.   +13 more
core   +2 more sources