Results 101 to 110 of about 2,608,035 (199)

A molecular approach to triple-negative breast cancer: targeting the Notch signaling pathway [PDF]

Einstein (São Paulo)
Introduction Triple-negative breast cancer is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. This phenotype renders triple-negative
Isabele Pardo, Pedro Brecheret Fagundes, Rafael Santana de Oliveira, Paulo Vidal Campregher   +3 more
doaj   +1 more source

CircDDX17 enhances coxsackievirus B3 replication through regulating miR-1248/NOTCH receptor 2 axis. [PDF]

Front Microbiol, 2022
Liu T, Li Y, Chen S, Wang L, Liu X, Yang Q, Wang Y, Qiao X, Tong J, Deng X, Shao S, Wang H, Shen H.   +12 more
europepmc   +1 more source

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.

PLoS ONE, 2011
Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin
Susan M L Banks, Bomsoo Cho, Suk Ho Eun, Ji-Hoon Lee, Sarah L Windler, Xuanhua Xie, David Bilder, Janice A Fischer   +7 more
doaj   +1 more source

A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse

Biology Open, 2018
Canonical Notch signaling requires the presence of a membrane bound ligand and a corresponding transmembrane Notch receptor. Receptor engagement induces multiple proteolytic cleavage events culminating in the nuclear accumulation of the Notch ...
Alexander M. Herman, Alexander M. Rhyner, W. Patrick Devine, Sean P. Marrelli, Benoit G. Bruneau, Joshua D. Wythe   +5 more
doaj   +1 more source

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud, Kerr, Matthew D, Mao, Angelo S, Mooney, David J, Raimondo, Theresa M, Scadden, David T, Shah, Nisarg J, Sharda, Azeem, Shih, Ting-Yu, Tager, Andrew M, Vrbanac, Vladimir D, Weaver, James C   +11 more
core   +1 more source

Furin, ADAM, and γ-secretase: Core regulatory targets in the Notch pathway and the therapeutic potential for breast cancer

Neoplasia: An International Journal for Oncology Research
The activation of the Notch pathway promotes the occurrence and progression of breast cancer. The Notch signal plays different roles in different molecular subtypes of breast cancer.
Kuo Yao, Xiang-Yi Zhan, Mei Feng, Ke-Fan Yang, Ming-Sheng Zhou, Hui Jia   +5 more
doaj   +1 more source

Systematic Evaluation for the Influences of the SOX17/Notch Receptor Family Members on Reversing Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells. [PDF]

Front Oncol, 2021
Du Z, Li L, Sun W, Zhu P, Cheng S, Yang X, Luo C, Yu X, Wu X.   +8 more
europepmc   +1 more source

Notch Receptor Intracellular Domain

Definitions, 2020

semanticscholar   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core  

An analysis of overall network architecture reveals an infinite-period bifurcation underlying oscillation arrest in the segmentation clock

, 2012
Unveiling the mechanisms through which the somitogenesis regulatory network exerts spatiotemporal control of the somitic patterning has required a combination of experimental and mathematical modeling strategies.
Santillán, Moisés, Zavala, Eder
core   +1 more source