Results 151 to 160 of about 2,608,184 (335)

The Notch Signaling Pathway: Mechanistic Insights in Health and Disease

Engineering
The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes. The Notch receptor is activated by two families of canonical ligands (Delta-like and Serrate/Jagged) where both ligands ...
Yao Meng, Zhihan Bo, Xinyi Feng, Xinyi Yang, Penny A. Handford   +4 more
doaj   +1 more source

E3 Ubiquitin Ligase Regulators of Notch Receptor Endocytosis: From Flies to Humans. [PDF]

Biomolecules, 2022
Revici R, Hosseini-Alghaderi S, Haslam F, Whiteford R, Baron M.   +4 more
europepmc   +1 more source

A molecular approach to triple-negative breast cancer: targeting the Notch signaling pathway [PDF]

Einstein (São Paulo)
Introduction Triple-negative breast cancer is an aggressive subtype of breast cancer characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. This phenotype renders triple-negative
Isabele Pardo, Pedro Brecheret Fagundes, Rafael Santana de Oliveira, Paulo Vidal Campregher   +3 more
doaj   +1 more source

CircDDX17 enhances coxsackievirus B3 replication through regulating miR-1248/NOTCH receptor 2 axis. [PDF]

Front Microbiol, 2022
Liu T, Li Y, Chen S, Wang L, Liu X, Yang Q, Wang Y, Qiao X, Tong J, Deng X, Shao S, Wang H, Shen H.   +12 more
europepmc   +1 more source

Vat Photopolymerized HEMA/HEA Hydrogels for Solvent‐Responsive Transparency and Optical Encryption

Advanced Optical Materials, EarlyView.
Vat‐photopolymerized HEMA/HEA hydrogels exhibit reversible transparency‐opacity switching via hydration‐induced microphase separation and solvent exchange. The printed materials enable hydration sensing, optical encryption, and information storage, while maintaining high ductility and reversible rheology.
Murad Ali, Mohammed Ayaz Uddin, Dileep Chekkaramkodi, Rashid K. Abu Al‐Rub, Haider Butt   +4 more
wiley   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.

PLoS ONE, 2011
Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin
Susan M L Banks, Bomsoo Cho, Suk Ho Eun, Ji-Hoon Lee, Sarah L Windler, Xuanhua Xie, David Bilder, Janice A Fischer   +7 more
doaj   +1 more source

A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse

Biology Open, 2018
Canonical Notch signaling requires the presence of a membrane bound ligand and a corresponding transmembrane Notch receptor. Receptor engagement induces multiple proteolytic cleavage events culminating in the nuclear accumulation of the Notch ...
Alexander M. Herman, Alexander M. Rhyner, W. Patrick Devine, Sean P. Marrelli, Benoit G. Bruneau, Joshua D. Wythe   +5 more
doaj   +1 more source

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud, Kerr, Matthew D, Mao, Angelo S, Mooney, David J, Raimondo, Theresa M, Scadden, David T, Shah, Nisarg J, Sharda, Azeem, Shih, Ting-Yu, Tager, Andrew M, Vrbanac, Vladimir D, Weaver, James C   +11 more
core   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source