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Developmental Dynamics, EarlyView.Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez +2 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
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PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner [PDF]
Cell Research, 2014 Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator of Notch receptor intracellular routing. When PKCζ was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch ...
Marika Sjöqvist +2 more
exaly +4 more sources
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Notch receptors and hematopoiesis
Experimental Hematology, 2001Notch receptors are involved in a variety of cell-fate decisions that affect the development and function of many organs, including hematopoiesis and the immune system. There are four mammalian Notch receptors that have only partially overlapping functions despite sharing similar structures and ligands.
S, Kojika, J D, Griffin
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The Notch-1 receptor in prostate tumorigenesis
Cancer Treatment Reviews, 2017The Notch signalling pathway plays a fundamental role in tissue development due to its involvement in cell fate determination and postnatal tissue differentiation. Its capacity to regulate cell growth and development has been linked to the occurrence of several cancers including that of the prostate.
Rebecca, O'Brien, Laure, Marignol
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Localization of ADAM10 and notch receptors in bone
Bone, 1999In Drosophila melanogaster, the role of the metallodisintegrin, Kuzbanian (kuz), is thought to involve activation of the Drosophila Notch receptor that plays a role in cell-fate determination during neurogenesis and myoblast differentiation. To understand the possible function(s) of a-disintegrin and metalloproteinase (ADAM10), the mammalian ortholog ...
D J, Dallas +5 more
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Endocytic Trafficking of the Notch Receptor
2018The endosomal pathway plays an important role in several aspects of Notch signalling ranging from ligand-dependent to independent activation and also degradation of the Notch receptor. Here, we will focus on its role during receptor degradation and describe the endosomal pathway with the components that are important for Notch degradation and the ...
Björn, Schnute +2 more
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Journal of Biological Chemistry, 2012 Notch signaling is critical for development and adult tissue physiology, controlling cell fate in a context-dependent manner. Upon ligand binding, the transmembrane Notch receptor undergoes two ordered proteolytic cleavages releasing Notch intracellular ...
Patricia Chastagner +2 more
exaly +2 more sources
Notch-1 and Notch-4 Receptors as Prognostic Markers in Breast Cancer
International Journal of Surgical Pathology, 2010Background: Studies looking at immunohistochemical (IHC) staining of Notch receptors in breast cancer and correlation with known prognostic factors are sparse. Methods: IHC staining for nuclear, cytoplasmic, and membrane Notch-1 (N1), Notch-4 (N4), and Jagged-1 (JAG1) was performed and correlated with known prognostic factors.
Yao K +6 more
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Notch receptor signal transduction
Experimental Hematology, 2000Abstract The Notch receptors participate in an evolutionarily conserved signaling pathway that regulates cell fate decisions. In hematopoiesis, Notch regulates T cell and B cell differentiation and may suppress differentiation of myeloid cells in vitro. Further, constitutive activation of Notch causes T-cell ALL in humans and mice.
L. Wu, J. Aster, J.D. Griffin
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