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Discrepancies of Notch 1 receptor during development of chronic seizures
Journal of Cellular Physiology, 2019 The critical role of Notch signaling has been shown in the pathogenesis of some neurological disorders including schizophrenia, epilepsy and Alzheimerâ s disease.
Sayed Mostafa Modarres Mousavi +2 more
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Intracellular trafficking of Notch receptors and ligands
Experimental Cell Research, 2009The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway.
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Tugging on Notch receptor tunes signaling
Science, 2017Signal Transduction Notch proteins are transmembrane receptors that are important in the regulation of cell fate. They are unusual in that their ligands are membrane-bound on adjacent cells. Luca et al. provide insights into the signaling interactions between Notch and its various ligands.
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Amyloid precursor protein interacts with notch receptors
Journal of Neuroscience Research, 2005The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate
Sun Young, Oh +8 more
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Notch-like Neurotrophin Receptor
Science Signaling, 2010A fragment of the p75 neurotrophin receptor appears to regulate transcription in the nucleus.
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[Signalling by Notch family receptors].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1997From nematode to man, the transmembrane receptors of the Notch family act throughout embryonic and post-embryonic development to regulate the acquisition and/or maintenance of specific differentiative states. We will review here our current state of knowledge on Notch receptors structure and signalling activity.
F, Schweisguth +3 more
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Evolution of Notch Transmembrane Receptors
2010Notch is the transmembrane receptor of a juxtacrine signalling pathway (Notch pathway) crucial for cell programming during animal development. The active Notch pathway is an innovation of the metazoan lineage: several major components of this molecular network are absent from other eukaryotes. The transmembrane multidomain protein Notch emerged through
Eve, Gazave, Renard, Emmanuelle
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Notch in Pericytes: Receptor Function and Targets
2020Angiogenesis is the process by which pre-existing blood vessels sprout to from new ones. Mural cell recruitment to the capillary endothelium is essential for the stabilization of a newly forming vascular bed during angiogenesis and is tightly regulated. Notch signaling is a pathway that regulates vessel function and pericyte recruitment.
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[Role of the Notch receptors in intercellular communication].
Pathologie-biologie, 1996The Notch gene was discovered in Drosophila at the beginning of the century and is currently the subject of intensive investigation, not only in invertebrates but also in vertebrates where remarkably well conserved homologues have been recently found. Notch encodes a new kind of cellular receptor whose functioning is still unclear and plays a role in a
L, Seugnet, P, Simpson
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Notch receptors as marker of glioma grading
2011Gliomas are the most common neoplasms of the Central Nervous System (CNS) and a frequent cause of mental impairment and death. Gliomas are grouped into four clinical World Health Organization (WHO) grades according to their degree of malignancy.
Dell'Albani P +6 more
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