Results 31 to 40 of about 60,049 (256)

Diagnostic value of epigastric ultrasound and suprasternal notch ultrasound in comparison with standard capnography in confirmation of endotracheal tube placement after intubation

Advanced Biomedical Research, 2023
Background: Endotracheal intubation is the basic method of providing a safe cross-sectional airway area and the incorrect placement can be dangerous and causes complications.
Saeed Majidinejad, Farhad Heydari, Mohamadreza Asadolahian   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Study on notch tensile properties of Fe-Mn-Si shape memory alloy

Materials Research Express
In order to investigate the effect of stress concentration on the mechanical properties of Fe-Mn-Si shape memory alloy, Fe17Mn5Si10Cr5Ni shape memory alloy was selected as the research object in this study.
Haojie Niu, Yubin Sun, Chengxin Lin
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Fatigue notch sensitivity as a function of the notch to grain size relationship

MATEC Web of Conferences, 2014
This work presents experimental results showing the mode I fatigue behaviour of holed components as a function of the hole to grain size relationship. A wide range of notch size to grain size ratios are used, including cases where the notch size is on ...
Lorenzino Pablo, Navarro Alfredo
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

NOTCH activity differentially affects alternative cell fate acquisition and maintenance

eLife, 2018
The pituitary is an essential endocrine gland regulating multiple processes. Regeneration of endocrine cells is of therapeutic interest and recent studies are promising, but mechanisms of endocrine cell fate acquisition need to be better characterised ...
Leonard Cheung, Paul Le Tissier, Sam GJ Goldsmith, Mathias Treier, Robin Lovell-Badge, Karine Rizzoti   +5 more
doaj   +1 more source

NOTCH pathway inactivation reprograms stem-like oral cancer cells to JAK-STAT dependent state and provides the opportunity of synthetic lethality

Translational Oncology, 2023
Background: We have recently provided the evidence of interconvertible cellular states, driving non-genetic heterogeneity among stem-like oral cancer cells (oral-SLCCs).
Subhashis Ghosh, Paromita Mitra, Uday Saha, Rimpa Nandi, Subhashree Jena, Arnab Ghosh, Shantanu Saha Roy, Moulinath Acharya, Nidhan Kumar Biswas, Sandeep Singh   +9 more
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Fatigue reliability of welded joints accounting for uncertainties in weld geometry

Advances in Mechanical Engineering, 2022
Fatigue reliability assessment of welded joints can consider the uncertainties from various sources and can establish the design criteria and inspection plans. The present paper aims to address the uncertainties explicitly. The notch strain approach that
Huiying Gao, Xiaoqiang Zhang, Peng Huang, Hao Jiang, Zhoushuo Li   +4 more
doaj   +1 more source