Results 11 to 20 of about 190,719 (307)
To Be, or Notch to Be: Mediating Cell Fate from Embryogenesis to Lymphopoiesis
Biomolecules, 2021 Notch signaling forms an evolutionarily conserved juxtacrine pathway crucial for cellular development. Initially identified in Drosophila wing morphogenesis, Notch signaling has since been demonstrated to play pivotal roles in governing mammalian ...
Han Leng Ng +3 more
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Notch Signaling in Leukemia [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2007 Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this ...
Jon C, Aster +2 more
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Molecules, 2021 Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua +6 more
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Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]
, 2015 In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano +9 more
core +3 more sources
Notch Signaling in Cancer [PDF]
Cancer Biology & Therapy, 2002 Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant ...
Allenspach, Eric J +3 more
openaire +3 more sources
Notch/Delta signaling constrains reengineering of pro-T cells by PU.1 [PDF]
, 2006 PU.1 is essential for early stages of mouse T cell development but antagonizes it if expressed constitutively. Two separable mechanisms are involved: attenuation and diversion. Dysregulated PU.1 expression inhibits pro-T cell survival, proliferation, and
Adams, Stephanie L. +8 more
core +3 more sources
Journal of the American Society of Nephrology, 2008 The Notch signaling pathway comprises a family of transmembrane receptors, ligands, negative and positive modifiers, and transcription factors with regulatory activity in multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis ...
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Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
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Notch signaling and Notch signaling modifiers [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
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The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
Medicines, 2018 There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC.
Adriana Harbuzariu +2 more
doaj +1 more source