Results 11 to 20 of about 107,106 (262)
Notch signalling in context [PDF]
Nature Reviews Molecular Cell Biology, 2016 The highly conserved Notch signalling pathway functions in many different developmental and homeostatic processes, which raises the question of how this pathway can achieve such diverse outcomes. With a direct route from the membrane to the nucleus, the Notch pathway has fewer opportunities for regulation than do many other signalling pathways, yet it ...
Sarah Bray
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Molecules, 2021 Notch signaling receptors, ligands, and their downstream target genes are dysregulated in pancreatic ductal adenocarcinoma (PDAC), suggesting a role of Notch signaling in pancreatic tumor development and progression.
Rashu Barua +6 more
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Notch Signaling in Cancer [PDF]
Cancer Biology & Therapy, 2002 Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant ...
Allenspach, Eric J +3 more
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Journal of the American Society of Nephrology, 2008 The Notch signaling pathway comprises a family of transmembrane receptors, ligands, negative and positive modifiers, and transcription factors with regulatory activity in multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis ...
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Notch signaling and Notch signaling modifiers [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
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The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
Medicines, 2018 There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC.
Adriana Harbuzariu +2 more
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Non-Canonical Notch Signaling in Cancer and Immunity
Frontiers in Oncology, 2014 Canonical Notch signaling is initiated by -secretase mediated cleavage of the Notch receptor, leading to the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-J, resulting in the activation of ...
Barbara A Osborne, Furkan eAyaz
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EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1
Scientific Reports, 2023 Notch signaling determines cell fates in mouse intestine. Notch receptors contain multiple epidermal growth factor-like (EGF) repeats modified by O-glycans that regulate Notch signaling.
Mohd Nauman +4 more
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Notch Signaling and Alloreactivity [PDF]
Transplantation, 2016 Solid organ and allogeneic hematopoietic cell transplantation have become standard therapeutic interventions that save patient lives and improve quality of life. Our enhanced understanding of transplantation immunobiology has refined clinical management and improved outcomes. However, organ rejection and graft-versus-host disease remain major obstacles
Vedran, Radojcic, Ivan, Maillard
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Journal of Cardiovascular Development and Disease, 2021 The Notch intercellular signaling pathways play significant roles in cardiovascular development, disease, and regeneration through modulating cardiovascular cell specification, proliferation, differentiation, and morphogenesis. The dysregulation of Notch
Angello Huerta Gomez +5 more
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