Results 211 to 220 of about 190,719 (307)

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source

The regulatory role of the Notch signaling pathway in mitophagy and macrophage-mediated elimination of Mycobacterium bovis bacillus Calmette-Guérin. [PDF]

BMC Infect Dis
Zhao Y, Li Q.
europepmc   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, EarlyView.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Significance of Notch Signaling in Salivary Gland Development and Diseases. [PDF]

J Clin Med
Sisto M, Lisi S.
europepmc   +1 more source

Leaky‐Integrate‐Fire Neuron via Synthetic Antiferromagnetic Coupling and Spin‐Orbit Torque

Advanced Science, EarlyView.
A spintronic leaky‐integrate‐and‐fire neuron is realized using Spin Orbit Torque driven domain‐wall motion for integration and synthetic antiferromagnetic coupling for the leaky process. The specialized Hall‐bar geometry enables controlled DW dynamics, achieving repeatable integration and firing events. This compact, CMOS‐compatible design highlights a
Badsha Sekh, Durgesh Kumar, Hasibur Rahaman, Ravi Shankar Verma, Ramu Maddu, Jianpeng Chan, Wai Lum William Mah, Stuart S. P. Parkin, S. N. Piramanayagam   +8 more
wiley   +1 more source

Systematic monocyte subset analysis reveals differential contribution of Notch signaling components to monocyte heterogeneity. [PDF]

iScience
Xu Y, Kapanadze T, Gaedcke S, Jirmo AC, Sablotny S, Schroth FN, Hille S, Müller OJ, Lochner M, Haller H, Schmidt-Ott K, Gamrekelashvili J, Limbourg FP.   +12 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Molecular impact of NOTCH signaling dysregulation on ovarian cancer progression, chemoresistance, and taxane response. [PDF]

Biomed Pharmacother
Koucka K, Spalenkova A, Seborova K, Tesarova T, Ehrlichova M, Krus I, Holy P, Rob L, Hruda M, Bouda J, Bartakova A, Smoligova V, Ojima I, Chen L, Bendale H, Mrhalova M, Kopeckova K, Soucek P, Vaclavikova R.   +18 more
europepmc   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Effects of Notch signaling on the lineage commitment of human peripheral blood monocyte trilineage progenitor under inflammatory conditions. [PDF]

Cell Death Discov
Aničić S, Filipović M, Krešić I, Jakšić O, Radošević M, Flegar D, Planinić P, Ikić Matijašević M, Jajić Z, Kelava T, Kovačić N, Šućur A, Grčević D.   +12 more
europepmc   +1 more source