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Notch Signaling Pathway

Science's STKE, 2006
Notch is a receptor that mediates intercellular signaling through a pathway conserved across the metazoa. It is involved in cell fate assignation and pattern formation during development. The receptor acts as a membrane-tethered transcription factor and is activated by members of the Delta, Serrate, Lag-2 family of Notch ligands, which trigger two ...
Matthias, Ehebauer   +2 more
openaire   +2 more sources

Biophysics of Notch Signaling

Annual Review of Biophysics, 2021
Notch signaling is a conserved system of communication between adjacent cells, influencing numerous cell fate decisions in the development of multicellular organisms. Aberrant signaling is also implicated in many human pathologies. At its core, Notch has a mechanotransduction module that decodes receptor–ligand engagement at the cell surface under ...
David, Sprinzak, Stephen C, Blacklow
openaire   +2 more sources

Modulators of Notch signaling

Seminars in Cell & Developmental Biology, 1998
In addition to the core components of the Notch pathway, a number of proteins have been identified that exert positive or negative influences on Notch signaling. These include extracellular modulators, which may influence binding or activation of Notch by its ligands, cytoplasmic modulators, which presumably influence signal transduction steps after ...
V M, Panin, K D, Irvine
openaire   +2 more sources

Notch signaling in neuroblastoma

Seminars in Cancer Biology, 2004
Neuroblastoma is a pediatric tumor that originates from precursor cells of the sympathetic nervous system that have discontinued their normal differentiation program. This review is focused on involvement of the Notch signaling cascade in the process of differentiation in neuroblastoma cells and normal cells of the sympathetic nervous system.
Sven, Påhlman   +3 more
openaire   +2 more sources

Notch signaling in lymphopoiesis

Seminars in Immunology, 2003
Notch signaling regulates many cell fate decisions during development of multi-cellular organisms. Signals initiated by Notch influence a wide variety of processes that include lineage specification, cell survival and proliferation, and border formation.
Warren S, Pear, Freddy, Radtke
openaire   +2 more sources

Notch Signaling and Ageing

2014
Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function. Notch genes are involved in embryogenesis, nervous system, and cardiovascular and endocrine function.
Eleftheria, Polychronidou   +4 more
openaire   +2 more sources

Notch signalling in hematopoiesis

Seminars in Cell & Developmental Biology, 2003
The Notch pathway is a widely utilized, evolutionarily conserved regulatory system that plays a central role in the fate decisions of multipotent precursor cells. Notch often acts by inhibiting differentiation along a particular pathway while permitting or promoting self-renewal or differentiation along alternative pathways.
K, Ohishi   +4 more
openaire   +2 more sources

Notch Signaling in Cancer

Current Molecular Medicine, 2006
The evolutionarily conserved developmental pathway driven by Notch receptors and ligands has acquired multiple post-natal homeostatic functions in vertebrates. Potential roles in human physiology and pathology are being studied by an increasingly large number of investigators.
Lucio, Miele   +2 more
openaire   +2 more sources

Introduction to Notch Signaling

2014
Notch signaling is probably the most widely used intercellular communication pathway. The Notch mutant in the fruit fly Drosophila melanogaster was isolated about 100 years ago at the dawn of genetics. Since then, research on Notch and its related genes in flies, worms, mice, and human has led to the establishment of an evolutionarily conserved ...
Shinya, Yamamoto   +2 more
openaire   +2 more sources

Deciphering Notch signaling notch by notch

Cell Signaling, 2023
Lidia Borkiewicz, Adolfo Rivero-Müller
openaire   +1 more source

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