Results 11 to 20 of about 152,934 (201)

Notch Signaling and T-Helper Cells in EAE/MS [PDF]

Clinical and Developmental Immunology, 2013
The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Ribal Bassil, William Orent, Wassim Elyaman   +2 more
doaj   +4 more sources

Notch Signaling Pathway and Human Placenta [PDF]

International Journal of Medical Sciences, 2012
Notch signaling was evolutionarily conserved and critical for cell-fate determination, differentiation and many other biological processes. Growing evidences suggested that Notch signaling pathway played an important role in the mammalian placental ...
Wei-Xiu Zhao, Jian-Hua Lin
doaj   +4 more sources

Dynamic Ligand Discrimination in the Notch Signaling Pathway [PDF]

Cell, 2018
The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear how such ligand discrimination could occur.
Nandagopal, Nagarajan, Santat, Leah A., LeBon, Lauren, Sprinzak, David, Bronner, Marianne E., Elowitz, Michael B.   +5 more
openaire   +5 more sources

Notch Signaling Pathway in Pancreatobiliary Tumors [PDF]

Medicina, 2021
Background and Objectives: The Notch signaling pathway plays an important role both in the development of the ductal systems of the pancreas and the bile ducts as well as in cancer development and progression. The aim of this study was to examine the expression of central proteins of the Notch signaling pathway in pancreatobiliary tumors and its ...
Francesca Borlak, Anja Reutzel-Selke, Anja Schirmeier, Julia Gogolok, Ellen von Hoerschelmann, Igor M. Sauer, Johann Pratschke, Marcus Bahra, Rosa B. Schmuck   +8 more
openaire   +3 more sources

Ubiquitinations in the Notch Signaling Pathway [PDF]

International Journal of Molecular Sciences, 2013
The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules.
Moretti, Julien, Brou, Christel
openaire   +2 more sources

An Orthologics Study of the Notch Signaling Pathway. [PDF]

Genes (Basel)
The Notch signaling pathway plays a major role in embryological development and in the ongoing life processes of many animals. Its role is to provide cell-to-cell communication in which a Sender cell, bearing membrane-embedded ligands, instructs a Receiver cell, bearing membrane-embedded receptors, to adopt one of two available fates.
Stein WD.
europepmc   +3 more sources

Mechanical regulation of the Notch signaling pathway

Current Opinion in Cell Biology, 2023
The mechanical regulation of Notch signaling is an emerging area of interest in cell biology. Notch is essential in many physiological processes in which mechanical stress plays an important role. This review provides an overview of the mechanoregulation of Notch signaling in multiple steps of the pathway. First, we discuss the current knowledge on the
Suarez Rodriguez, Freddy, Sanlidag, Sami, Sahlgren, Cecilia   +2 more
openaire   +2 more sources

Notch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer

BMC Cancer, 2022
Background The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Notch signaling mutation for ...
Fei Wang, Chuan Huang, Jie Long, Zhi-Bin Zhao, Hai-Qing Ma, Xue-Qing Yao, Liang Li, Zhe-Xiong Lian   +7 more
doaj   +1 more source

Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation.

PLoS ONE, 2014
The aberrant activation of Notch-1 signaling pathway has been proven to be associated with the development and progression of cancers. However, the specific roles and the underlying mechanisms of Notch-1 signaling pathway on the malignant behaviors of ...
Li Li, Fenglong Zhao, Juan Lu, Tingting Li, Hong Yang, Chunhui Wu, Yiyao Liu   +6 more
doaj   +1 more source

Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]

, 2019
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I, Hofmann, Inga, Kong, Guangyao, Letson, Christopher, Liu, Yangang, Loh, Mignon, Padron, Eric, Pear, Warren S, Qian, Shuiming, Rajagopalan, Adhithi, Ranheim, Erik A, Stieglitz, Elliot, Wen, Zhi, Yang, David, You, Xiaona, Zhang, Jing, Zhang, Jingfang, Zhang, Xinmin, Zhong, Xuehua, Zhou, Lan, Zhou, Yun   +20 more
core   +1 more source