Results 21 to 30 of about 152,934 (201)

Notch signaling during human T cell development [PDF]

, 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy, A Krueger, A Sambandam, A Wilson, A Wolfer, AC Jaleco, AI Garbe, AP Weng, B Blom, B Reizis, B Vandekerckhove, BN Weber, C Benne, CC Tydell, CN Ting, D Hockemeyer, D Hockemeyer, E Robey, EM Six, ES David-Fung, F Klein, F Radtke, F Radtke, F Timmermans, F Weerkamp, F Weerkamp, G Awong, H Hirata, H Neves, H Wang, HT Petrie, HY Kueh, I Hoebeke, I Maillard, I Maillard, I Walle Van de, I Walle Van de, J Buer, J Gotter, J Plum, J Shi, JS Yuan, K Heinzel, K Hozumi, K Li, K Maki, K Tanigaki, L Li, M Ciofani, M Ciofani, M Ciofani, M Garcia-Peydro, M Ghisi, M Magri, M Smedt De, M Smedt De, M Smedt De, M Smedt De, MA Yui, MD Green, ML Joachims, N Lefort, P Beatus, P Doerfler, P Li, QL Hao, QL Hao, R Haddad, RN Motte-Mohs La, S Coppernolle Van, S Doulatov, S Gonzalez-Garcia, S Suliman, S Verbeek, SK Durum, SK Ye, SM Lehar, SY Lee, T Hosoya, T Ikawa, T Ikawa, T Kreslavsky, T Kreslavsky, T Palomero, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, TB Feyerabend, TM Schmitt, TN Taghon, W Dontje, WA Dik, Y Wu, YR Carrasco, Z Galic   +97 more
core   +2 more sources

Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle [PDF]

, 2013
Articles in International JournalsThe transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key ...
A Fischer, a Hess R, a Hess R, Alexandre Trindade, António Duarte, AR Bellvi, B Bielesz, BR Nebel, C Afonso, C Firlit, C Zeng, Daniel Murta, Domingos Henrique, E Assa-Kunik, E Silva, E Silva, EF OAKBERG, EJ Lambie, EJ Ward, Elisabete Silva, F Batista, G Dirami, H Takanaga, H-T Cheng, HB Ariyaratne, I Sörensen, J Boucher, J Kimble, J Lu, J Zavadil, Jean-Marc A. Lobaccaro, K Hasegawa, K Shimizu, KL Hahn, LT Krebs, Luís Lopes-da-Costa, M Lupien, M Morimoto, M Rahmana, M Stahl, M-C Hofmann, Marta Batista, Mruk Wong, EWP Dolores D, R Bultje, R Habert, RM Das, S Artavanis-Tsakonas, S Kimmins, S Mori, SS Saravanamuthu, T Borggrefe, T DeFalco, T Hayashi, T Hayashi, T Kitamoto, TX Garcia, V Von Schönfeldt, X Feng, X Song, Y Clermont, Y Kitadate, Y Niwa, Y Wang, Z Sahin, Z Yuan   +64 more
core   +11 more sources

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states [PDF]

, 2014
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch ...
Elowitz, Michael B., Jafar-Nejad, Hamed, LeBon, Lauren, Lee, Tom V., Sprinzak, David   +4 more
core   +1 more source

The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain

Molecular Brain, 2012
Background The Notch signaling pathway has been shown to be involved in the development of the nervous system. Recent studies showed that Notch receptors and ligands are also expressed in the nervous system of adult animals.
Sun Yan-Yan, Li Li, Liu Xiao-Hua, Gu Nan, Dong Hai-Long, Xiong Lize   +5 more
doaj   +1 more source

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

Evolving Roles of Notch Signaling in Cortical Development

Frontiers in Neuroscience, 2022
Expansion of the neocortex is thought to pave the way toward acquisition of higher cognitive functions in mammals. The highly conserved Notch signaling pathway plays a crucial role in this process by regulating the size of the cortical progenitor pool ...
Fang-Shin Nian, Fang-Shin Nian, Pei-Shan Hou, Pei-Shan Hou   +3 more
doaj   +1 more source

Notch signaling in serous ovarian cancer [PDF]

, 2014
Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors.
Foster, Rosemary, Groeneweg, Jolijn W, Growdon, Whitfield B, Rueda, Bo R, Verheijen, René HM   +4 more
core   +1 more source

The Notch signaling pathway: Transcriptional regulation at Notch target genes [PDF]

Cellular and Molecular Life Sciences, 2009
The Notch gene encodes a transmembrane receptor that gave the name to the evolutionary highly conserved Notch signaling cascade. It plays a pivotal role in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development.
Borggrefe, T., Oswald, F.
openaire   +3 more sources

Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation

Neoplasia: An International Journal for Oncology Research, 2019
Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models.
Elise S. Hibdon, Nataliya Razumilava, Theresa M. Keeley, Gabriela Wong, Sumeet Solanki, Yatrik M. Shah, Linda C. Samuelson   +6 more
doaj   +1 more source

Notch signalling pathway in development of cholangiocarcinoma

World Journal of Gastrointestinal Oncology, 2020
Cholangiocarcinoma (CCA) comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile duct. The incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian regions.
Rauff, Bisma, Malik, Arif, Bhatti, Yasir Ali, Chudhary, Shafiq Ahmad, Qadri, Ishtiaq, Rafiq, Shafquat   +5 more
openaire   +2 more sources