Results 21 to 30 of about 156,496 (347)

Notch signaling in serous ovarian cancer [PDF]

, 2014
Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors.
Foster, Rosemary, Groeneweg, Jolijn W, Growdon, Whitfield B, Rueda, Bo R, Verheijen, René HM   +4 more
core   +1 more source

Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]

, 2019
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I, Hofmann, Inga, Kong, Guangyao, Letson, Christopher, Liu, Yangang, Loh, Mignon, Padron, Eric, Pear, Warren S, Qian, Shuiming, Rajagopalan, Adhithi, Ranheim, Erik A, Stieglitz, Elliot, Wen, Zhi, Yang, David, You, Xiaona, Zhang, Jing, Zhang, Jingfang, Zhang, Xinmin, Zhong, Xuehua, Zhou, Lan, Zhou, Yun   +20 more
core   +1 more source

The spinal notch signaling pathway plays a pivotal role in the development of neuropathic pain

Molecular Brain, 2012
Background The Notch signaling pathway has been shown to be involved in the development of the nervous system. Recent studies showed that Notch receptors and ligands are also expressed in the nervous system of adult animals.
Sun Yan-Yan, Li Li, Liu Xiao-Hua, Gu Nan, Dong Hai-Long, Xiong Lize   +5 more
doaj   +1 more source

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

Evolving Roles of Notch Signaling in Cortical Development

Frontiers in Neuroscience, 2022
Expansion of the neocortex is thought to pave the way toward acquisition of higher cognitive functions in mammals. The highly conserved Notch signaling pathway plays a crucial role in this process by regulating the size of the cortical progenitor pool ...
Fang-Shin Nian, Fang-Shin Nian, Pei-Shan Hou, Pei-Shan Hou   +3 more
doaj   +1 more source

Dynamic Ligand Discrimination in the Notch Signaling Pathway [PDF]

Cell, 2018
The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear how such ligand discrimination could occur.
Nagarajan Nandagopal, Leah A. Santat, Lauren LeBon, David Sprinzak, Marianne Bronner‐Fraser, Michael B. Elowitz   +5 more
openalex   +4 more sources

Notch signaling during human T cell development [PDF]

, 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy, A Krueger, A Sambandam, A Wilson, A Wolfer, AC Jaleco, AI Garbe, AP Weng, B Blom, B Reizis, B Vandekerckhove, BN Weber, C Benne, CC Tydell, CN Ting, D Hockemeyer, D Hockemeyer, E Robey, EM Six, ES David-Fung, F Klein, F Radtke, F Radtke, F Timmermans, F Weerkamp, F Weerkamp, G Awong, H Hirata, H Neves, H Wang, HT Petrie, HY Kueh, I Hoebeke, I Maillard, I Maillard, I Walle Van de, I Walle Van de, J Buer, J Gotter, J Plum, J Shi, JS Yuan, K Heinzel, K Hozumi, K Li, K Maki, K Tanigaki, L Li, M Ciofani, M Ciofani, M Ciofani, M Garcia-Peydro, M Ghisi, M Magri, M Smedt De, M Smedt De, M Smedt De, M Smedt De, MA Yui, MD Green, ML Joachims, N Lefort, P Beatus, P Doerfler, P Li, QL Hao, QL Hao, R Haddad, RN Motte-Mohs La, S Coppernolle Van, S Doulatov, S Gonzalez-Garcia, S Suliman, S Verbeek, SK Durum, SK Ye, SM Lehar, SY Lee, T Hosoya, T Ikawa, T Ikawa, T Kreslavsky, T Kreslavsky, T Palomero, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, TB Feyerabend, TM Schmitt, TN Taghon, W Dontje, WA Dik, Y Wu, YR Carrasco, Z Galic   +97 more
core   +2 more sources

Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling [PDF]

, 2016
The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular decoding
A Djiane, A Ghysen, A Krejci, A Krejci, A Rogulja-Ortmann, A Schmid, AC Nagel, AM Bailey, B Kahali, B Kramatschek, B Pfeuty, BA Edgar, BE Housden, BE Housden, C Bivik, C Delidakis, C Peterson, C Ulvklo, CA Meyer, Caroline Bivik, CQ Doe, CQ Doe, CQ Doe, D Karlsson, D Karolchik, D Pan, DA Lehman, DF Poulson, E Knust, E Wurmbach, EC Lai, EC Lai, EP Spana, Erika Gunnar, F Liu, Francois Schweisguth, H Schmidt, H Schrons, I Miguel-Aliaga, I Rebay, I Wech, J Bischof, J Culi, J Hirata, JA Knoblich, JB Skeath, JB Skeath, JF de Celis, JL Cooper, JQ Boone, K Hori, K White, Khalil Mazouni, KJ Venken, L Jones, L Li, M Baumgardt, M Baumgardt, M Kohwi, M Lecourtois, MJ Lundell, MJ Vogel, N Giagtzoglou, O Birkholz, P Ligoxygakis, Paul H. Taghert, R Kageyama, R Kannan, R Karcavich, R Kopan, R Kopan, R Kushwah, R Lehmann, R Urbach, RL Trott, Ryan B. MacDonald, S Chanet, S Higashijima, S Yamamoto, SL Lai, SP Choksi, Stefan Thor, T Novotny, T Tsuji, TH Liu, UC Karandikar, YN Jan, Z Wang, Z Wang   +88 more
core   +5 more sources

The Notch signaling pathway: Transcriptional regulation at Notch target genes [PDF]

Cellular and Molecular Life Sciences, 2009
The Notch gene encodes a transmembrane receptor that gave the name to the evolutionary highly conserved Notch signaling cascade. It plays a pivotal role in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development.
Borggrefe, T., Oswald, F.
openaire   +3 more sources

Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation

Neoplasia: An International Journal for Oncology Research, 2019
Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models.
Elise S. Hibdon, Nataliya Razumilava, Theresa M. Keeley, Gabriela Wong, Sumeet Solanki, Yatrik M. Shah, Linda C. Samuelson   +6 more
doaj   +1 more source