Results 51 to 60 of about 156,496 (347)
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Frontiers in Immunology, 2021 The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation ...
Panagiotis F. Christopoulos +8 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2015 Background: The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role of Notch signaling in adipogenic differentiation of human bone marrow derived ...
Bao-quan Song +12 more
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Biological Significance of NOTCH Signaling Strength
Frontiers in Cell and Developmental Biology, 2021 The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
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Glycosylated notch and cancer [PDF]
, 2016 Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development.
Couto, Africa +3 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode [PDF]
, 2008 The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2^+ ectoderm gives rise not only to the otic placode but also to the surrounding cranial epidermis, and that Wnt ...
Groves, Andrew K. +3 more
core
Targeting Notch signalling pathway of cancer stem cells [PDF]
Stem Cell Investigation, 2018 Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. CSCs have been increasingly identified in blood cancer, prostate, ovarian, lung, melanoma, pancreatic, colon, brain and many more malignancies.
Vandana, Venkatesh +8 more
openaire +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
The Scientific World Journal, 2013 The Notch signaling is an evolutionarily conserved cell-cell communication pathway that plays critical roles in the proliferation, survival, apoptosis, and fate determination of mammalian cells.
Weiwei Liu +9 more
doaj +1 more source
Cell Regeneration, 2012 Background Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic ...
Yin Wenguang +7 more
doaj +1 more source