Results 51 to 60 of about 152,934 (201)

Glycosylated notch and cancer [PDF]

, 2016
Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development.
Couto, Africa, Georgiou, Marios, Nagarajan, Usha, Pakkiriswami, Shanmugasundaram   +3 more
core   +1 more source

Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases

Frontiers in Immunology, 2021
The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation ...
Panagiotis F. Christopoulos, Torleif T. Gjølberg, Torleif T. Gjølberg, Torleif T. Gjølberg, Stig Krüger, Guttorm Haraldsen, Jan Terje Andersen, Jan Terje Andersen, Eirik Sundlisæter   +8 more
doaj   +1 more source

An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets [PDF]

PeerJ, 2020
Notch family proteins play a key role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis ...
Dimitrios Vlachakis, Louis Papageorgiou, Ariadne Papadaki, Maria Georga, Sofia Kossida, Elias Eliopoulos   +5 more
doaj   +2 more sources

Targeting Notch signalling pathway of cancer stem cells [PDF]

Stem Cell Investigation, 2018
Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. CSCs have been increasingly identified in blood cancer, prostate, ovarian, lung, melanoma, pancreatic, colon, brain and many more malignancies.
Vandana, Venkatesh, Raghu, Nataraj, Gopenath S, Thangaraj, Murugesan, Karthikeyan, Ashok, Gnanasekaran, Shanmukhappa B, Kaginelli, Gobianand, Kuppanna, Chandrashekrappa Gowdru, Kallappa, Kanthesh M, Basalingappa   +8 more
openaire   +2 more sources

SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1

Cell Regeneration, 2012
Background Notch is one of the most important signaling pathways involved in cell fate determination. Activation of the Notch pathway requires the binding of a membrane-bound ligand to the Notch receptor in the adjacent cell which induces proteolytic ...
Yin Wenguang, Liu Dapeng, Liu Nian, Xu Liangliang, Li Song, Lin Shuo, Shu Xiaodong, Pei Duanqing   +7 more
doaj   +1 more source

Biological Significance of NOTCH Signaling Strength

Frontiers in Cell and Developmental Biology, 2021
The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
doaj   +1 more source

PEAR1 Promotes Myoblast Proliferation Through Notch Signaling Pathway. [PDF]

Biology (Basel)
PEAR1, also known as platelet endothelial aggregation receptor 1, is known to play a crucial role in the migration and differentiation of muscle satellite cells (MuSCs). However, its specific effects on skeletal muscle development and regeneration require further exploration.
Zhao Y, Zhang L, Hao R, Li S, Li S, Shi S, Tong H, Liu B.   +7 more
europepmc   +4 more sources

Cis-activation in the Notch signaling pathway

eLife, 2018
The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling. Here, by analyzing Notch activation in single cells while controlling cell density and ligand expression ...
Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz   +2 more
openaire   +4 more sources

NOTCH, a new signaling pathway implicated in holoprosencephaly [PDF]

Human Molecular Genetics, 2010
Genetics of Holoprosencephaly (HPE), a congenital malformation of the developing human forebrain, is due to multiple genetic defects. Most genes that have been implicated in HPE belong to the sonic hedgehog signaling pathway. Here we describe a new candidate gene isolated from array comparative genomic hybridization redundant 6qter deletions, DELTA ...
Dupé, Valérie, Rochard, Lucie, Mercier, Sandra, Le Pétillon, Yann, Gicquel, Isabelle, Bendavid, Claude, Bourrouillou, Georges, Kini, Usha, Thauvin-Robinet, Christel, Bohan, Timothy, Odent, Sylvie, Dubourg, Christèle, David, Véronique   +12 more
openaire   +3 more sources

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]

, 2015
In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Di Ianni, Mauro, Falzetti, Franca, Marconi, Pierfrancesco, Rosati, Emanuela, Sabatini, Rita, Screpanti, Isabella, Sportoletti, Paolo   +9 more
core   +3 more sources