Results 61 to 70 of about 152,934 (201)

Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask

Cell Communication and Signaling
Background Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar, Jyoti Singh, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee   +4 more
doaj   +1 more source

Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells

The Scientific World Journal, 2013
The Notch signaling is an evolutionarily conserved cell-cell communication pathway that plays critical roles in the proliferation, survival, apoptosis, and fate determination of mammalian cells.
Weiwei Liu, Guorong Jin, Chongde Long, Xin Zhou, Yan Tang, Shan Huang, Xielan Kuang, Lizi Wu, Qingjiong Zhang, Huangxuan Shen   +9 more
doaj   +1 more source

Genomic control of patterning [PDF]

, 2009
The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome.
Davidson, Eric H., Peter, Isabelle S.
core   +2 more sources

The roles and activation of endocardial Notch signaling in heart regeneration

Cell Regeneration, 2021
As a highly conserved signaling pathway in metazoans, the Notch pathway plays important roles in embryonic development and tissue regeneration. Recently, cardiac injury and regeneration have become an increasingly popular topic for biomedical research ...
Huicong Li, Cheng Chang, Xueyu Li, Ruilin Zhang   +3 more
doaj   +1 more source

THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES

Mediterranean Journal of Hematology and Infectious Diseases, 2019
The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma.
Sorrentino C., Cuneo A., Roti G.
openaire   +5 more sources

Notch signaling in cancers: mechanism and potential therapy

Frontiers in Cell and Developmental Biology
The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive
Chen Chen, Yan Du, Rongzu Nie, Shuangshuang Wang, Hang Wang, Peifeng Li   +5 more
doaj   +1 more source

Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions

Journal of Diabetes Research, 2013
The involvement of the Notch signaling pathway in the cellular differentiation of the mammalian kidney is established. Recently, the dysregulation of Notch signaling molecules has been identified in acute and chronic renal injuries, fibrosis models, and ...
Li Liu, Chenlin Gao, Guo Chen, Xia Li, Jia Li, Qin Wan, Yong Xu   +6 more
doaj   +1 more source

Role of Notch Signaling Pathway in Glioblastoma Pathogenesis [PDF]

Cancers, 2019
Notch signaling is an evolutionarily conserved pathway that regulates important biological processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation. In mammals, Notch signaling is composed of four receptors (Notch1–4) and five ligands (Dll1-3–4, Jagged1–2) that mainly contribute to the development and maintenance ...
Riccardo Bazzoni, Angela Bentivegna
openaire   +2 more sources

Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway [PDF]

, 2017
we read with great interest the paper by Dr. Chen et al1, recently published in European Review for Medical and Pharmacological Sciences and titled ‘‘Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the ...
Assirati G, Ballarin R, Battistelli C, Di Benedetto F, Guerrini GP, Magistri P, Mereu F, Tarantino G   +7 more
core  

Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation [PDF]

, 2018
Glioblastoma (GBM) is the most aggressive human brain tumor. The high growth potential and decreased susceptibility to apoptosis of the glioma cells is mainly dependent on genetic amplifications or mutations of oncogenic or pro-apoptotic genes ...
Bevilacqua, Valeria, Caffarelli, Elisa, De Jaco, Antonella, Di Bari, Maria, Laneve, Pietro, Piovesana, Roberta, Talora, Claudio, Tata, Ada Maria, Trobiani, Laura   +8 more
core   +2 more sources