Results 61 to 70 of about 23,054 (234)

Fibroblasts to Keratinocytes Redox Signaling: The Possible Role of ROS in Psoriatic Plaque Formation

Antioxidants, 2019
Although the role of reactive oxygen species-mediated (ROS-mediated) signalling in physiologic and pathologic skin conditions has been proven, no data exist on the skin cells ROS-mediated communication. Primary fibroblasts were obtained from lesional and
Victoria Barygina, Matteo Becatti, Francesca Prignano, Torello Lotti, Niccolò Taddei, Claudia Fiorillo   +5 more
doaj   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Nox4 mediates skeletal muscle metabolic responses to exercise [PDF]

, 2021
Full author list omitted for brevity. For the full list of authors, see article.OBJECTIVE: The immediate signals that couple exercise to metabolic adaptations are incompletely understood.
Kant, Shashi, Caliz, Amada D., Specht, Kalyn S., Keaney, John F. Jr., Pei, Yongmei, Craige, Siobhan M., Learnard, Heather, Reif, Michaella M., Campbell, Maura   +8 more
core   +1 more source

Innovation of plant‐derived extracellular vesicles and interdisciplinary research: From discovery to biomedical applications

BMEMat, EarlyView.
Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li, Yi Wei, Ben Hu, Yafang Song, Xiaojia Chen, Nik Ahmad Nizam Nik Malek, Tongkai Chen   +6 more
wiley   +1 more source

Alternative Splicing of NOX4 in the Failing Human Heart [PDF]

Frontiers in Physiology, 2017
Increased oxidative stress is a major contributor to the development and progression of heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) isoenzymes, especially on NOX4 is controversial. Therefore, we aimed to characterize NOX4 expression in human samples from healthy and failing hearts. Explanted human heart samples
Zoltán V. Varga, Zoltán V. Varga, Márton Pipicz, Júlia A. Baán, Tamás Baranyai, Gábor Koncsos, Przemyslaw Leszek, Mariusz Kuśmierczyk, Fátima Sánchez-Cabo, Pablo García-Pavía, Gábor J. Brenner, Zoltán Giricz, Zoltán Giricz, Tamás Csont, Luca Mendler, Luca Mendler, Enrique Lara-Pezzi, Pál Pacher, Péter Ferdinandy, Péter Ferdinandy, Péter Ferdinandy   +20 more
openaire   +7 more sources

NOX4 knockdown decreased TRPC1 and TRPC6 expression under both control and BMP4 treatment circumstances.

, 2014
A: Western blot analysis of TRPC1 protein after knockout of NOX4 in rat distal PASMCs, of which the upper band is TRPC1, the following band is α-actin; NC and NOX4 siRNA group indicate negative control group and NOX4 knockout group respectively.
Wenju Lu (430078), Kai Yang (73590), Lichun Tian (320047), Jie Zhang (64655), Yuqin Chen (627602), Xiuqing Chen (627603), Jian Wang (5901), Xin Fu (448766), Qian Jiang (216582)   +8 more
core   +1 more source

Cannabidiol attenuates arsenic-induced nephrotoxicity via the NOX4 and NF-κB pathways in mice

Research in Pharmaceutical Sciences
Background and purpose: Cannabidiol (CBD) is a phenolic terpene compound with anticancer, antioxidant, anti-inflammatory, antibacterial, neuroprotective, and anticonvulsant properties.
Ali Vadizadeh, Maryam Salehcheh, Hadi Kalantar, Layasadat Khorsandi, Mohammad Rashno, Masoud Mahdavinia   +5 more
doaj   +1 more source

NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway

Journal of Nanobiotechnology, 2022
Periprosthetic osteolysis (PPO) triggered by wear particles is the most severe complication of total joint replacement (TJR) surgeries, representing the major cause of implant failure, which is public health concern worldwide.
Wei Wang, Xiaolong Liang, Xin Liu, Jiaxiang Bai, Wei Zhang, Wenming Li, Tianhao Wang, Meng Li, Zerui Wu, Liang Chen, Huilin Yang, Ye Gu, Yunxia Tao, Jun Zhou, Huaiyu Wang, Dechun Geng   +15 more
doaj   +1 more source

Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5‐Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aims to explore the involvement and mechanism of ferroptosis in particulate matter 2.5 (PM2.5)–induced membranous nephropathy (MN) progression. A cationic bovine serum albumin (cBSA)–induced mouse model of MN was established, followed by PM2.5 exposure.
Yanhong Gao, Yinfeng Guo, Shaoyan Xu, Min Zhang, Yanxia Rui, Shujun Pan, Changhua Zhou, Jianxiang Chen, Henglan Wu   +8 more
wiley   +1 more source

Characterisation of Nox4 Inhibitors from Edible Plants [PDF]

Planta Medica, 2013
NADPH oxidases transport electrons from cytosolic NADPH through biological membranes to generate reactive oxygen species. NADPH oxidase 4, broadly expressed in humans, is an interesting pharmacological target, since its activity is deregulated in several diseases, including pulmonary fibrosis, diabetic nephropathy, and cardiac hypertrophy.
Kofler, Philipp, Pircher, Haymo, Grafenstein, Susanne von, Diener, Thomas, Höll, Monika, Liedl, Klaus R., Siems, Karsten, Jansen-Dürr, Pidder   +7 more
openaire   +3 more sources