Results 71 to 80 of about 23,054 (234)

NOX4 knockdown downregulated BMP4 induced ROS generation in rat distal PASMCs.

, 2014
A: Western blot analysis of NOX4 siRNA affecting NOX4 protein in rat distal PASMCs, of which the upper band is NOX4, the following band is α-actin. NC group, NOX4-205 siRNA group and NOX4-1048 siRNA group indicate negative control group, NOX4 siRNA group
Wenju Lu (430078), Kai Yang (73590), Lichun Tian (320047), Jie Zhang (64655), Yuqin Chen (627602), Xiuqing Chen (627603), Jian Wang (5901), Xin Fu (448766), Qian Jiang (216582)   +8 more
core   +1 more source

The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice

Redox Biology, 2021
Objective: The NADPH oxidase Nox4 is an important source of H2O2. Nox4-derived H2O2 limits vascular inflammation and promotes smooth muscle differentiation.
Giulia K. Buchmann, Christoph Schürmann, Manuela Spaeth, Wesley Abplanalp, Lukas Tombor, David John, Timothy Warwick, Flávia Rezende, Andreas Weigert, Ajay M. Shah, Martin-Leo Hansmann, Norbert Weissmann, Stefanie Dimmeler, Katrin Schröder, Ralf P. Brandes   +14 more
doaj   +1 more source

Combined effects of kombucha consumption and aerobic exercise on oxidative stress and metabolic parameters in Wistar rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background Kombucha, a fermented tea containing symbiotic bacteria and yeast, and aerobic exercise each confer distinct health benefits, but their combined effects remain poorly understood. This study investigated the combined effects of consuming kombucha fermented for 7 days and performing moderate aerobic exercise on physiological outcomes ...
Jean Carlos Costa Nogueira, Luis Paulo Santos Ribas, Raquel Moura, Jean Ramos Boldori, Alexsander Pedroso Garcia, Kaueli Rodrigues Amaral, Franciele Aline Smaniotto, Tatiana Emanuelle, Cristiane Casagrande Denardin   +8 more
wiley   +1 more source

ВЛИЯНИЕ ПРОИЗВОДНЫХ ФУЛЛЕРЕНОВ С ОДНОЙ МИНОРНОЙ ЗАМЕНОЙ В ТИОФЕНОВОМ АДДЕНДЕ НА УРОВЕНЬ ЭКСПРЕССИИ NADPH-ОКСИДАЗЫ 4 В ЭМБРИОНАЛЬНЫХ ФИБРОБЛАСТАХ ЛЕГКОГО ЧЕЛОВЕКА

Journal of Bioinformatics and Genomics
Поиск высокоэффективных антиоксидантов является актуальной медико-биологической задачей. Фуллерены и их производные обладают высокой антиоксидантной активностью, что делает их потенциальными препаратами для лечения заболеваний, вызванных активными ...
Савинова Е.А., Костюк С.В., Проскурнина Е.В., Ершова Е.С., Каменева Л.В., Вейко Н.Н., Савинов А.Л., Большакова В.С., Краевая О.А., Трошин П.А.   +9 more
doaj   +1 more source

Interplay between RNA-binding protein HuR and Nox4 as a novel therapeutic target in diabetic kidney disease

Molecular Metabolism, 2020
Objective: Glomerular injury is a prominent pathological feature of diabetic kidney disease (DKD). Constitutively active NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species that mediates hyperglycemia-induced mesangial cell (MC) fibrotic ...
Qian Shi, Doug-Yoon Lee, Denis Féliers, Hanna E. Abboud, Manzoor A. Bhat, Yves Gorin   +5 more
doaj   +1 more source

NET‐Associated Inflammatory Markers in Head and Neck Squamous Cell Carcinoma: Bioinformatic Prioritization and Exploratory Serum Assessment in Patients Undergoing Radiotherapy

Molecular Carcinogenesis, EarlyView.
ABSTRACT Neutrophil extracellular traps (NETs) and inflammatory mediators have been implicated in head and neck squamous cell carcinoma, but their relationship with systemic inflammatory status during radiotherapy remains incompletely understood. This exploratory integrative study combined a literature‐guided network‐based bioinformatic prioritization ...
Eloa Mangabeira Santos, Daniela Fernanda de Freitas, David Fernando Colón, Rangel Leal Silva, Alfredo Maurício Batista de Paula, Lucyana Conceição Farias, Bruno Rodrigues Gonçalves, Andréia Luiza Oliveira Costa, Sérgio Henrique Sousa Santos, Fernando Queiroz Cunha, Donald Fernandes, André Luiz Sena Guimarães   +11 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

NOX4: A Guilty Party in Stroke Damage

PLoS Biology, 2010
​IschemicIschemic stroke is a dangerous medical condition that occurs when blood supply to brain tissues is lost. This usually happens as a result of substantial blood pressure drops, or when blood vessels are blocked by clots. In either case, affected tissues can die, often leading to permanent impairment of mental and physical faculties, the shutdown
openaire   +4 more sources

Endogenous Hydrogen Sulfide Ameliorates NOX4 Induced Oxidative Stress in LPS-Stimulated Macrophages and Mice

, 2018
Background/Aims: Sepsis is a severe and complicated syndrome that is characterized by dysregulation of host inflammatory responses and organ failure.
Li-Long Pan, Ming Qin, Yi Zhun Zu, Peng Xu, Wan-Wan Jia, Si-Yu Liu, Di Yan, Xin-Hua Liu, Xi-Ling Wang, Fen Long, Wei-Jun Wu   +10 more
core   +2 more sources

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source