Results 91 to 100 of about 23,054 (234)

Nox4 is dispensable for exercise induced muscle fibre switch

, 2015
Introduction: By producing H2O2, the NADPH oxidase Nox4 is involved in differentiation of mesenchymal cells. Exercise alters the composition of slow and fast twitch fibres in skeletal.
Min Zhang, Vogel, Juri, Susanne Rohrbach (756415), Juri Vogel (756413), Rezende Felipe, Flávia Figueiredo de, Katrin Schröder, Susanne Rohrbach, Min Zhang (111999), Zhang, Min, Zhang, Min; id_orcid, Flávia Figueiredo de Rezende, Katrin Schröder (665150), Rohrbach, Susanne, Juri Vogel, Schröder, Katrin, Flávia Figueiredo de Rezende (756414), De Rezende, Flávia Figueiredo, Zhang Min, Schröder Katrin, Figueiredo de Rezende Flávia, Vogel Juri, Rohrbach Susanne   +21 more
core   +1 more source

Evaluating the Expression of NOX2 and NOX4 Signaling Pathways in Rats’ Lung Tissues Following Local Chest Irradiation; Modulatory Effect of Melatonin [PDF]

International Journal of Molecular and Cellular Medicine, 2018
Lung injury is one of the major concerns for chest cancer patients that undergo radiotherapy as well as persons exposed to an accidental radiological event.
Masoud Najafi, alireza shirazi, Elahe Motevaseli, Ghazale Geraily, Peyman Amini, Dheyauldeen Shabeeb, Ahmed Eleojo Musa   +6 more
doaj  

Genome‐wide association and interaction analysis for proliferative retinopathy in adults with type 2 diabetes born during famine: The DOLCE study in Ukraine

Acta Ophthalmologica, EarlyView.
Abstract Purpose Proliferative diabetic retinopathy (PDR) is one of the leading causes of blindness in working‐age adults. We have previously shown that the risk of PDR is significantly elevated in individuals with intrauterine exposure to famine. However, the genetic mechanisms mediating this association remain unknown.
Olena Fedotkina, Most Champa Begum, Xuan Tung Trinh, Turkuler Özgumus, Mikael Åkerlund, Peter Nilsson, Leticia Maria Spindola, Valeriya Lyssenko   +7 more
wiley   +1 more source

Mechanismen der Aktivitätsregulation der NADPH-Oxidase NOX4

, 2016
Die NADPH-Oxidasen stellen eine wichtige Quelle für reaktive Sauerstoffspezies (Reactive oxygen species; ROS) im Organismus dar. Hierbei dienen die NADPH-Oxidasen nicht nur der Pathogenabwehr, sondern haben einen Einfluss auf eine Vielzahl an oxidativen,
Prior, Kim-Kristin (M.Sc.)
core  

MicroRNA 148a Suppresses Tuberculous Fibrosis by Targeting NOX4 and POLDIP2

, 2022
Extracellular matrix production by pleural mesothelial cells in response to Mycobacterium tuberculosis contributes to tuberculous fibrosis. NOX4 is involved in the pathogenesis of tuberculous fibrosis.
Seong Ji Woo, Harry Jung, Youngmi Kim, Jae Jun Lee, Ji Young Hong   +4 more
core   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Overexpressing Nox1 and Nox4 increases ROS production.

, 2017
Total RNA was collected from F9 cells transfected with an empty vector (EV) control, pcDNA3.1-Nox1 or pcDNA3.1-Nox4 and cultured 4 days. (A) Nox1 and (B) Nox4 expression following transfection of pcDNA3.1-Nox1 or pcDNA3.1-Nox4, respectively, and relative
Benjamin J. Dickson (3712885), Danielle M. Spice (3712888), Mohamed I. Gatie (3712882), Gregory M. Kelly (338508)   +3 more
core   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

The role of NOX4 in skin fibroblasts

, 2021
La différenciation des fibroblastes en myofibroblastes consiste en une conversion phénotypique des fibroblastes en cellules positives pour le marqueur “α-smooth muscle actin” (α-SMA), hautement contractiles et qui sécrètent des protéines de la matrice extracellulaire.
openaire   +1 more source

Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease

Journal of Diabetes Research, 2018
Background. NADPH oxidase 4 (NOX4) plays a major role in renal oxidative stress of diabetic kidney disease (DKD). NOX4 was significantly increased in Egr1-expressing fibroblasts, but the relationship between Egr1 and NOX4 in DKD is unclear. Methods.
Fang Hu, Meng Xue, Yang Li, Yi-Jie Jia, Zong-Ji Zheng, Yan-Lin Yang, Mei-Ping Guan, Liao Sun, Yao-Ming Xue   +8 more
doaj   +1 more source