Results 101 to 110 of about 23,054 (234)

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

NOX4-dependent regulation of ENaC in hypertension and diabetic kidney disease

, 2020
NADPH oxidase 4 (NOX4) is the most abundant NOX isoform in the kidney; however, its importance for renal function has only recently emerged. The NOX4-dependent pathway regulates many factors essential for proper sodium handling in the distal nephron ...
Isaeva, Elena, Khedr, Sherif, Palygin, Oleg, Ilatovskaya, Daria V, Cowley, Allen W, Blass, Gregory, Staruschenko, Alexander, Pavlov, Tengis S, Levchenko, Vladislav   +8 more
core   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source

Nox4 gene knockdown promoted T. gondii replication.

, 2013
ARPE-19 cells were transfected with Nox4-specific siRNA for 48 h. (A) Nox4 knockdown efficiency was determined by western blot. (B) Intracellular ROS levels were measured by flow cytometry after DHE staining.
Juan-Hua Quan (422684), Dae-Whan Shin (422686), Guang-Ho Cha (73482), Young-Ha Lee (422685), Wei Zhou (24328)   +4 more
core   +1 more source

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy [PDF]

, 2016
Aims/hypothesis Changes in podocyte morphology and function are associated with albuminuria and progression of diabetic nephropathy. NADPH oxidase 4 (NOX4) is the main source of reactive oxygen species (ROS) in the kidney and Nox4 is upregulated in ...
Quaggin, Susan E., Jandeleit-Dahm, Karin A., Banal, Claudine, Thallas-Bonke, Vicki, Schmidt, Harald H. H. W., Cooper, Mark E., Gray, Stephen P., Chow, Bryna S. M., Ramm, Georg, Jha, Jay C.   +9 more
core   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells

, 2016
Activating mutations of FMS-like tyrosine kinase 3 (FLT3), notably internal tandem duplications (ITDs), are associated with a grave prognosis in acute myeloid leukemia (AML).
Fischer, M., Scholl, S., Frey, S., Moriggl, R., Barth, J., Heidel, F. H., Sperr, W. R., Serve, H., Böhmer, F. D., Valent, P., Fischer, T., Berg, T., Lässig, J., Müller, J. P., Schröder, K., Bauer, R., Maurer, B., Oellerich, T., Cerny-Reiterer, S., Böhmer, S. A., Jayavelu, A. K., Shah, A. M.   +21 more
core   +1 more source