Results 121 to 130 of about 23,054 (234)

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages [PDF]

, 2017
Altered metabolism has been implicated in the pathogenesis of inflammatory diseases. NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological functions that may be of importance in inflammation and in the pathogenesis of ...
윤주헌
core   +1 more source

Alpinia oxyphylla Miq.: Chemical Constituents, Neuroprotective and Metabolic Effects, and Translational Challenges—A Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Alpinia oxyphylla Miq. (AOM), a medicinal and edible resource, contains diphenylheptanoids, polysaccharides, flavonoids, terpenoids, and phenolic acids. These constituents exert multi‐target synergistic effects by modulating neuroinflammation, oxidative stress, and the PI3K/Akt pathway, thereby improving Alzheimer's disease, Parkinson's disease, and ...
Ziyan Yang, Hemei Yuan, Dengyou Nie, Jun Sheng, Titi Liu, Huanhuan Xu   +5 more
wiley   +1 more source

Effects of Nox4 inhibition on hypoxia-induced ROS generation.

, 2019
HK-2 cells were exposed to hypoxia for 24 hr. Confocal microscopy images of cells subjected to dihydroethidium (DHE) staining with and without Nox4 knockdown (A) or treated with and without GKT137831 (B).
Hoi Young Lee (4763172), Dong-Chan Jin (6996851), Sung-Ro Yun (4763163), Seong-Lan Yu (4763154), Se-Hee Yoon (4516729), Chang Gyo Park (4763166), Bo Young Jeong (4763151), Won-Min Hwang (4763157), Jaeku Kang (2818651), Ho Seung Song (6996854), Moon Hyang Park (761855), Young-Bin Yu (3425891), Sungkwon Cho (4763160)   +12 more
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The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction

, 2020
Oxidative stress attributable to the activation of a Nox4-containing NADPH oxidase is involved in aging-associated vascular dysfunction. However, the Nox4-induced signaling mechanism for the vascular alteration in aging remains unclear. In an aged aorta,
Yang, S, Kim, HK, Lee, HY, Hoang, TH, Kim, HR, Chae, HJ, Siyoung Yang, The-Hiep Hoang, Han-Jung Chae, Hyun-Kyoung Kim, Hyung-Ryong Kim, Hwa-Young Lee   +11 more
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NADPH Oxidase 4-Derived H2O2 Promotes Aberrant Retinal Neovascularization via Activation of VEGF Receptor 2 Pathway in Oxygen-Induced Retinopathy

Journal of Diabetes Research, 2015
NADPH oxidase 4 (Nox4) is a major isoform of NADPH oxidase in retinal endothelial cells. Our previous study suggests that upregulation of Nox4 in retinal endothelial cells contributes to retinal vascular leakage in diabetes.
Jingming Li, Joshua J. Wang, Sarah X. Zhang   +2 more
doaj   +1 more source

Vaccarin Improves Myocardial Ischemia–Reperfusion Injury by Attenuating Oxidative Stress and Ferroptosis Through Reducing NOX4‐Modulated JAK2/STAT3 Pathway Activation

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 11, November 2026.
ABSTRACT Vaccarin is a naturally occurring flavonoid glycoside with cardioprotective properties; however, its involvement in myocardial ischemia–reperfusion (MI/R) injury remains poorly defined. We herein investigated whether vaccarin protects cardiomyocytes from MI/R‐induced dysfunction in vivo and in vitro and examined the associated molecular ...
Han Yang, Mi Zhou, Feng‐Cai Zhang
wiley   +1 more source

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

, 2017
The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity.
Bijaya K. Nayak, Karen Block, William E. Friedrichs, Ronald Rodriguez, Karthigayan Shanmugasundaram, Dharam Kaushik   +5 more
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Neointimal Hyperplasia and Restenosis: Epidemiology, Pathophysiology, Animal Models, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
The overall graphical diagram to summarize the pathological characteristics, pathogenesis, clinical manifestation, preclinical animal models, diagnostic methods, and intervention strategies for neointimal hyperplasia. Neointimal hyperplasia results from excessive proliferation and intimal migration of vascular smooth muscle cells (VSMCs) in the ...
Kaixu Wang, Daiyu Zhang, Yu Hu, Yixin Zhao, Xinling Wang, Long Jiang, Meixiu Jiang   +6 more
wiley   +1 more source

Hypoxia induces Nox4 expression.

, 2019
HK-2 cells were exposed to hypoxia using hypoxia chamber. (A) Quantitative real time PCR for Nox homologues (Nox2, Nox4 and Nox5) at 0, 3, 6, and 12 h after hypoxia exposure.
Hoi Young Lee (4763172), Dong-Chan Jin (6996851), Sung-Ro Yun (4763163), Seong-Lan Yu (4763154), Se-Hee Yoon (4516729), Chang Gyo Park (4763166), Bo Young Jeong (4763151), Won-Min Hwang (4763157), Jaeku Kang (2818651), Ho Seung Song (6996854), Moon Hyang Park (761855), Young-Bin Yu (3425891), Sungkwon Cho (4763160)   +12 more
core   +1 more source

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source