Results 131 to 140 of about 23,054 (234)

CHD4 and NOX4 expression in thyroid tumor tissues

Exploration of Targeted Anti-tumor Therapy
Aim: Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core NURD remodeling complex ATPase that plays a crucial role as a gene repressor. Its overexpression has been reported in several cancers. In papillary thyroid carcinomas (PTCs), CHD4 is overexpressed and associated with aggressive features of the tumor, such as proliferation, migration, and
Salma Fenniche, Mohamed Oukabli, Yassire Oubaddou, Allaoui Mohamed, Mohamed Reda Elochi, Abir Alghuzlan, Abdelilah Laraqui, Nadia Dakka, Youssef Bakri, Corinne Dupuy, Rabii Ameziane El Hassani   +10 more
openaire   +2 more sources

Recombinant ADAMTS13 Ameliorates Liver Injury and Improves Hepatic Microcirculation in a Murine Acute‐on‐Chronic Liver Failure Model

Hepatology Research, Volume 56, Issue 11, Page 1737-1748, November 2026.
ABSTRACT Aim The therapeutic significance of recombinant a disintegrin‐like and metalloprotease with thrombospondin type 1 motif 13 (rADAMTS13) in acute‐on‐chronic liver failure (ACLF) remains unclear. We aimed to investigate the therapeutic effects of rADAMTS13 in a murine model of ACLF‐like liver injury.
Jun‐ichi Hanatani, Norihisa Nishimura, Kosuke Kaji, Masayoshi Takami, Hiroyuki Masuda, Hiroaki Takaya, Koh Kitagawa, Shinya Sato, Tadashi Namisaki, Hitoshi Yoshiji   +9 more
wiley   +1 more source

Overexpression of Nox4 mimics metabolic priming and promotes monocyte adhesion.

, 2013
THP-1 monocytes were infected with adenoviruses (Ad, MOI = 50) expressing Nox4 under the control of a doxycycline (Dox)-sensitive promoter. Nox4 expression was induced by adding Dox (1 ug/ml) to the culture medium. Monocyte adhesion in response to MCP-1 (
Chi Fung Lee (423301), Hong Seok Kim (423303), Reto Asmis (423304), Sarah Ullevig (423302)   +3 more
core   +1 more source

NOX4-related ROS couples PET micro- and nanoplastic exposure to JAK2/STAT3 activation in clear cell renal cell carcinoma

Ecotoxicology and Environmental Safety
The potential influence of polyethylene terephthalate micro- and nanoplastics (PET-MNPs) on the progression of clear cell renal cell carcinoma (ccRCC) remains insufficiently defined.
Xiao-Hu Wu, Wen-Tao Xu, Wen-Cai Zheng, Zi-Heng Yan, Zhen Wang, Shao-Hao Chen, Fei Lin, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue, Ning Xu   +10 more
doaj   +1 more source

Cardiovascular protection by Nox4 [PDF]

Cardiovascular Research, 2018
openaire   +2 more sources

NOX4 serves as a pan-cancer prognostic biomarker and therapeutic target in tumorigenesis

Scientific Reports
NADPH oxidase 4 (NOX4) is a key regulator of intracellular reactive oxygen species (ROS) and plays a critical role in tumorigenesis and cancer progression.
Jiting Sun, Zhiyuan Gong, Lijie Zheng, Zhixian Ding, Lusheng Wang, Yu Tang, Shizhan Deng, Yonggan Dong, Heng Tang   +8 more
doaj   +1 more source

Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22 ℎ N-Terminus: An Elusive Target [PDF]

, 2020
Although NADPH oxidase 4 (Nox4) is the most abundant Nox isoform in systemic vascular endothelial and smooth muscle cells, its function in the vascular tissue is not entirely known.
Patrick J Pagano, Gábor Csányi
core  

Genetic and Pharmacological Inhibition of NOX4 Protects Against Rhabdomyolysis-Induced Acute Kidney Injury Through Suppression of Endoplasmic Reticulum Stress

Antioxidants
Rhabdomyolysis is a severe condition that commonly leads to acute kidney injury (AKI), with limited targeted treatments for rhabdomyolysis-induced AKI (RIAKI) adding to the challenge.
Zhuyun Zhang, Jiameng Li, Shanshan Chen, Jing Peng, Xinyao Luo, Liya Wang, Ruoxi Liao, Yuliang Zhao, Shu Zhang, Baihai Su   +9 more
doaj   +1 more source

Nox4 in Sport-induzierter Angiogenese

, 2016
Bewegung und sportliche Aktivität fördern die Gesundheit des Organismus und senken das Risiko chronischer Krankheiten. Sie bewirken dabei eine Vielzahl von physiologischen und biochemischen Veränderungen in der Skelettmuskulatur, insbesondere ...
Vogel, Juri (Dr. rer. med.)
core  

Nox4 mediates insulin-induced HIF-1α mRNA and protein expression.

, 2012
HMVECs were transfected with Nox4 siRNA or the control siRNA for 24 hours. The cells were growth arrested and then treated with 100 nM insulin for 12 hours. (A) HIF-1α mRNA levels were analyzed by real time-PCR.
Aihong Mei (124144), Sifeng Chen (124155), Xueling Kang (124150), Ruizhe Qian (124153), Junxu Liu (124146), Xianglin Shi (13689), Dan Meng (124143)   +6 more
core   +1 more source