Results 111 to 120 of about 23,054 (234)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Application and Research Progress of Nucleic Acid‐Based Drug Delivery Systems in the Treatment of Intracerebral Hemorrhage

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
This review summarizes recent advances in NADDS for treating ICH, highlighting the advantages and applications of key delivery technologies including lipid nanoparticles, exosomes, and DNA nanostructures. ABSTRACT Intracerebral hemorrhage (ICH) is a devastating stroke subtype associated with high mortality and neurological disability, yet effective ...
Jingyan Wang, Xuejiao Zeng, Pengyu Niu, Jinjin Shi, Wenyan Yu   +4 more
wiley   +1 more source

NOX4 modulates breast cancer progression through cancer cell metabolic reprogramming and CD8+ T cell antitumor activity

Frontiers in Immunology
IntroductionBreast cancer is the most frequently diagnosed malignancy and a leading cause of cancer-related mortality among women worldwide. Although NADPH oxidase 4 (NOX4) has been implicated in various oncogenic processes, its exact function in breast ...
Yingying Xiong, Yiming Weng, Shan Zhu, Jian Qin, Jia Feng, Xiaopeng Jing, Chao Luo, Wei Gong, Rui Sun, Min Peng   +9 more
doaj   +1 more source

The Amazonian “Bacuri” Seeds Butter (Platonia insignis Mart.) Improves Ex Vivo Aortic Vascular Dysfunction and In Vivo Oxidative Stress in L‐NAME‐Treated Rats

Phytochemicals in Food and Medicine, Volume 1, Issue 4, December 2026.
Industrialised bacuri seed butter (Platonia insignis Mart.) exhibited antioxidant and vasorelaxant effects, improving vascular reactivity and oxidative stress biomarkers in hypertensive rats. These findings highlight MIB as a promising natural product for mitigating hypertension‐associated vascular dysfunction and oxidative stress.
Maisa Gomes da Silva, Simone Kelly Rodrigues Lima, Angélica Gomes Coelho, Mariely Mendes Furtado, Andressa Amorim dos Santos, Ana Victória da Silva Mendes, Izabel Costa Barros, Isadora Basilio Meneses Bezerra, Ana Karolinne da Silva Brito, Benedito Pereira de Sousa Neto, Oskar Almeida Silva, Guilherme Antônio Lopes de Oliveira, Waldilleny Ribeiro de Araújo Moura, Maria do Carmo de Carvalho e Martins, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo   +16 more
wiley   +1 more source

Regulation of Nox4 by Calcineurin in the Diabetic Kidney

The FASEB Journal, 2012
Diabetic nephropathy is a leading cause of morbidity and mortality and is due to the detrimental effects of hyperglycemia. Hypertrophy, an early response to hyperglycemia, may contribute to pathological changes in the kidney. Previously, we found that calcineurin (Cnβ) is required for diabetic hypertrophy.
Clintoria R. Williams, Ramesh N. Reddy, Jennifer L. Gooch   +2 more
openaire   +1 more source

Generation and validation of NOX4 knockout (KO) HeLa cell lines.

, 2017
(A) T7 endonuclease 1(T7E1) assay. HeLa cells were transiently transfected with either pX459/NOX4 gRNA #1 or pX459/NOX4 gRNA #2, and genomic PCR products were analyzed by T7E1 assay (left panel).
Minsu Jang (2817730), Andrew J. Morris (206326), Junsoo Park (147202), Naser Jafari (3666577), Rackhyun Park (735914), Cai Huang (106394), Liqing Li (1584388), Hyunju Kim (124616)   +7 more
core   +1 more source

Astragaloside IV and Ferroptosis Modulation in Pathological Cardiac Hypertrophy: Current Evidence, an Integrative Hypothesis, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Pathological cardiac hypertrophy is initially an adaptive response to sustained mechanical, neurohormonal, or metabolic stress; however, it can progress to fibrosis, contractile dysfunction, arrhythmia, and heart failure. Ferroptosis is a type of regulated cell death caused by iron‐dependent phospholipid peroxidation.
Pengbo Liu, Yongzhi Deng
wiley   +1 more source

Inhibition of NADPH Oxidase 4 (NOX4) Signaling Attenuates Tuberculous Pleural Fibrosis

, 2019
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase [NOX] enzymes serve several hemostatic and host defense functions in various lung diseases, but the role of NOX4 signaling in tuberculous pleurisy is not well understood.
You Sun Noh, Harry Jung, Youngmi Kim, Jae Jun Lee, So Yeong Park, Ji Young Hong   +5 more
core   +1 more source

Porphyromonas gingivalis and Ferroptosis: Evidence, Limitations, and Significance

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontal dysbiosis and has been linked to multiple systemic diseases. Ferroptosis is a form of regulated cell death driven by iron‐dependent lipid peroxidation, and accumulating evidence implicates it in P. gingivalis‐associated tissue injury.
Xiaoting Fang, Xiaoyue Xu, Tingting Wei, Siyang Lu, Guili Qin, Hong Chen   +5 more
wiley   +1 more source

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

, 2012
Rationale: The function of Nox4, a source of vascular H2O2, is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction.Objective: We determined the function of Nox4 in situations of increased stress induced by ischemia or ...
Shah, Ajay M., Mieth, Anja, Luedike, Peter, Kruse, Christoph, Weissmann, Norbert, Michaelis, U. Ruth, Zhang, Min; id_orcid, Pliquett, Rainer, Kosowski, Judith, Dimmeler, Stefanie, Benkhoff, Sebastian, Schroeder, Katrin, Brandes, Ralf P.   +12 more
core   +1 more source