Results 131 to 140 of about 33,925 (257)
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati +12 more
wiley +1 more source
Summary: Genetic variants in ABCA7, an Alzheimer’s disease (AD)-associated gene, elevate AD risk, yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9-mediated abca7 knockout zebrafish to explore ABCA7’s role in AD.
Hüseyin Tayran +27 more
doaj +1 more source
Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts
The peptidic neurotransmitter neuropeptide Y (NPY) has been functionally implicated in feeding behavior, cardiovascular regulation, control of neuroendocrine axes, affective disorders, seizures, and memory retention.
Pedrazzini, T.
core +1 more source
Abstract Optical coherence tomography (OCT) enables visualization and quantification of the cutaneous microvasculature, yet no study has compared responses to distinct forms of heating in humans. We hypothesized that local skin heating (LH) would evoke larger responses in microvascular diameter, velocity, flow and density than passive whole‐body ...
Kristanti W. Wigati +5 more
wiley +1 more source
Neuropeptide Y (NPY) and NPY receptors in the rat pineal gland
NPY is considered to play an important role in pineal function, because it is co-stored with the dominant pineal transmitter noradrenaline. However, little evidence from the literature suggests that NPY alone is a strong regulator of melatonin synthesis ...
Hauser, F., Mikkelsen, J. D., Olcese, J.
core +1 more source
The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract
Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley +1 more source
Activity dynamics in the NPY neuronal signaling of mPFC in response to an air puff
These studies were designed to elucidate the role of NPY in modulating the responses of mPFC to acute stress in mice. Fiberoptic photometry recorded a robust increase in the NPY fluorescent signal in the mPFC during exploration of the elevated O-maze ...
Eugene Dimitrov +2 more
doaj +1 more source
A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp–Logan
ABSTRACT A customizable, dynamic geometric phantom was developed to bridge the gap between simplistic static phantoms and highly realistic, complex 4D solutions. The phantom enables initial testing, helps detect implementation errors, and supports quantitative evaluation of new dynamic acquisition and reconstruction methods.
Tamás Hakkel +4 more
wiley +1 more source
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio +2 more
wiley +1 more source

