Results 131 to 140 of about 4,156 (159)

Clock gene NR1D1 might be a novel target for the treatment of bladder cancer

Urologic Oncology: Seminars and Original Investigations, 2023
To explore the role of circadian clock gene NR1D1 (REV-erbα) in bladder cancer (BC).Firstly, the association of NR1D1 level with clinical characteristics and prognosis was investigated among patients diagnosed with BC. Secondly, CCK-8, transwell, and colony formation experiments were performed among BC cells treated with Rev-erbα agonist (SR9009), as ...
Yunjin Bai, Ping Han, Dengxiong Li
exaly   +3 more sources

Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis

International Journal of Molecular Sciences, 2023
Background: Ulcerative colitis (UC) is a chronic, incurable condition characterized by mucosal inflammation and intestinal epithelial cell (IEC) damage. The circadian clock gene NR1D1, implicated in UC and the critical mitophagy process for epithelial repair, needs further exploration regarding its role in mitophagy regulation in UC.
Liangru Zhu, Yidong Chen, Junrong Li
exaly   +3 more sources

Expanding the spectrum of mesenchymal neoplasms with NR1D1‐rearrangement

Genes, Chromosomes and Cancer, 2022
AbstractUndifferentiated mesenchymal neoplasms can be morphologically subclassified based on cell shape; epithelioid tumors may be diagnostically challenging, particularly since they can show morphologic and immunohistochemical overlap with epithelial neoplasms. Following the recent report of an NR1D1::MAML1 gene fusion in an undifferentiated pediatric
Maribel D. Lacambra, Cristina R. Antonescu, Chit Chow, Wang Kei Chiu, Elizabeth G. Demicco, Peter C. Ferguson, David Swanson, Ka‐Fai To, Lei Zhang, Brendan C. Dickson   +9 more
openaire   +2 more sources

Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging

International Journal of Molecular Sciences, 2022
Background: Circadian rhythm is associated with the aging process and sex differences; however, how age and sex can change circadian regulation systems remains unclear. Thus, we aimed to evaluate age- and sex-related changes in gene expression and identify sex-specific target molecules that can regulate aging.
Hee Jin Jung, Hae Young Chung, Daeui Park   +2 more
exaly   +3 more sources

NR1D1 enhances oxidative DNA damage by inhibiting PARP1 activity

Molecular and Cellular Endocrinology, 2017
Cancer cells exhibit an elevated intracellular level of reactive oxygen species (ROS) because of their accelerated metabolism, mitochondrial dysfunction, and antioxidant deficit. The oxidative stress in cancer cells may provide clinical benefits, which can be associated with a better response to anticancer therapies.
Mi-Ock Lee, Na-Lee Ka, Tae-Young Na
exaly   +3 more sources

Inhibition of mPGES‐2 ameliorates NASH by activating NR1D1 via heme

Hepatology, 2022
Background and Aims: Nonalcoholic fatty liver disease (NAFLD), a complex metabolic syndrome, has limited therapeutic options. Microsomal prostaglandin E synthase‐2 (mPGES‐2) was originally discovered as a prostaglandin E2 (PGE2) synthase; however, it does not produce PGE2 in the liver.
Dandan Zhong, Jie Cai, Cheng Hu, Jingshuo Chen, Rumeng Zhang, Chenyu Fan, Shanshan Li, Hongxing Zhang, Zhou Xu, Zhanjun Jia, Dong Guo, Ying Sun   +11 more
openaire   +2 more sources

Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes [PDF]

Biochemical and Biophysical Research Communications, 2017
ApoA4 exerts anti-inflammatory effects, but the mechanism remains unclear. SERPINA3 is a member of the serine proteinase inhibitor gene family, and has been shown to be involved in anti-inflammation and associated with a number of human diseases. In this study, we revealed that ApoA4 stimulates the gene expression of SERPINA3 in mouse hepatocytes both ...
Patrick Tso, Zongfang Li
exaly   +3 more sources

Soft tissue tumor with novel NR1D1-MAML1 fusion in a pediatric case

Virchows Archiv, 2020
We herein describe soft tissue tumor arising in the lower extremity of a pediatric patient. The tumor displayed a unique and wide range of histological features, sheet-like and cohesive growth pattern consisting of enlarged round to epithelioid atypical cells with a large alveolar and pseudopapillary histological architecture, focally mimicking ...
Masato Komatsu, Nobuyuki Yamamoto, Teruya Kawamoto, Yohei Kawakami, Hitomi Hara, Suguru Uemura, Noriyuki Nishimura, Toshihiro Akisue, Ryosuke Kuroda, Kazumoto Iijima, Naoe Jimbo, Maki Kanzawa, Kazuyoshi Kajimoto, Tomoo Itoh, Takanori Hirose   +14 more
openaire   +2 more sources

Apolipoprotein A-IV Reduces Hepatic Gluconeogenesis through Nuclear Receptor NR1D1 [PDF]

Journal of Biological Chemistry, 2014
We showed recently that apoA-IV improves glucose homeostasis by enhancing pancreatic insulin secretion in the presence of elevated levels of glucose. Therefore, examined whether apolipoprotein A-IV (apoA-IV) also regulates glucose metabolism through the suppression of hepatic gluconeogenesis.
Patrick Tso, W Sean Davidson, Silvana Obici   +2 more
exaly   +3 more sources

Bisphenol A attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling

Chemosphere, 2021
Bisphenol A (BPA) is an endocrine-disrupting compound that impairs testosterone synthesis in male mammals. A circadian clock gene deficiency leads to diminished fertility and even infertility in male mice. However, whether circadian clock signaling pathways mediate the suppressive effect of BPA on testosterone synthesis in Leydig cells (LCs) remains ...
Yaping Jin, Wei Liu, Wang Aihua
exaly   +3 more sources