Results 141 to 150 of about 4,156 (159)

NR1D1 targeting CYP19A1 inhibits estrogen synthesis in ovarian granulosa cells

Theriogenology, 2022
The circadian system performs an important role in mammalian reproduction with significant effects on hormone secretion. Nuclear receptor subfamily 1 group D member 1 (NR1D1) functions as a transcriptional repressor in the circadian system and affects granulosa cells (GCs), but how it regulates estrogen synthesis has not been clarified. We investigated
Liguang, Wang, Jingjing, Li, Lutong, Zhang, Shengjie, Shi, Xiaoge, Zhou, Yamei, Hu, Lei, Gao, Gongshe, Yang, Weijun, Pang, Huatao, Chen, Lijia, Zhao, Guiyan, Chu, Chuanjiang, Cai   +12 more
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NR1D1 in tumorigenesis: dual roles, mechanisms, and therapeutic targeting

Gene
Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα), a core circadian regulator, plays context-dependent dual roles in cancer, acting as either a tumor suppressor or oncogene. This review synthesizes current evidence on NR1D1's regulation of key oncogenic pathways: DNA repair, immunomodulation (e.g., the cyclic GMP-AMP ...
Zhuangwei, Lv, Ruohao, Yang, Jinhua, Wu, Xiaoyu, Shi, Ruihan, Wang, Yi'ang, Niu, Zhuang, Qian, Junna, Jiao, Yunfeng, Ma   +8 more
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NR1D1 (REVERBalpha) may be novel candidate gene for coronary artery disease in men: Differential effects of NR1D1 polymorphisms by gender

Chronobiology International
Circadian rhythms are strongly linked to cardiometabolic syndromes such as coronary artery disease (CAD). NR1D1(REVERBalpha) regulates lipid metabolism and circadian clock. This study investigated possible associations between the NR1D1 rs2314339 C > T and rs72836608 C > A polymorphisms and metabolic parameters in 126 CAD patients and 125 controls ...
Yilmaz-Aydogan, Hulya, Ebeoglu, Abdullah Omer, Yildiz, Ahmet, Tokat, Bengu, Yesil, Rukiye, Ozturk, Oguz, Ozkara, Gulcin, Seyhan, MEHMET FATİH, Aydogan, Cagatay   +8 more
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Mitophagy Regulates the Circadian Rhythms by Degrading NR1D1 in Simulated Microgravity and Isolation Environments

International Journal of Molecular Sciences
Long-term spaceflight is known to induce disruptions in circadian rhythms, which are driven by a central pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus, but the underlying molecular mechanisms remain unclear. Here, we developed a rat model that simulated microgravity and isolation environments through tail suspension and ...
Lina Qu, Sihai Zhou, Chuanjie Zhang
exaly   +3 more sources

Overexpression of NR1D1 Portends Disease Recurrence in Thyroid Cancer

The Journal of Clinical Endocrinology & Metabolism
Abstract Context Dysregulation of circadian rhythms has been linked to cancer susceptibility. Thyroid cancer cells demonstrate altered circadian oscillations in endogenous clock transcripts. Objective Our previous research identified ...
Yi-Chiung Hsu, Chi-Yu Kuo, Ming-Nan Chien, Jie-Yang Jhuang, Shih-Yuan Huang, Shao-Chiang Chang, Shih-Ping Cheng   +6 more
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Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5

American Journal of Physiology-Cell Physiology, 2022
Autophagy of granulosa cells (GCs) is involved in follicular atresia, which occurs repeatedly during the ovarian development cycle. Several circadian clock genes are rhythmically expressed in both rodent ovarian tissues and GCs. Nuclear receptor subfamily 1 group D member 1 (NR1D1), an important component of the circadian clock system, is involved in ...
Jing Zhang, Lijia Zhao, Yating Li, Hao Dong, Haisen Zhang, Yu Zhang, Tiantian Ma, Luda Yang, Dengke Gao, Xiaoyu Wang, Haizhen Jiang, Chao Li, Aihua Wang, Yaping Jin, Huatao Chen   +14 more
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Circadian Cadence and NR1D1 Tune Cardiovascular Disease

Journal of the American College of Cardiology, 2022
Filip K, Swirski, Cameron S, McAlpine
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NR1D1::MAML3 Fusion in an Aggressive Mesenchymal Neoplasm

Genes, Chromosomes and Cancer
ABSTRACTNR1D1‐rearranged tumors are distinct mesenchymal neoplasms with epithelioid morphology and aggressive potential. This report presents an 85‐year‐old male with a slow‐growing sternal mass identified as a pseudo‐cyst, characterized by a dense proliferation of epithelioid tumor cells.
Minh Chau Ta, Camille Gandon, Maxence Mancini, Philippe Lantier, Olaf Mercier, Samia Mourah, Maxime Battistella   +6 more
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Role of NR1D1 in Colorectal Cancer: Impact on Prognosis, Immune Microenvironment, and Oncogenic Pathways

Clinical Laboratory
The goal was to explore the impact of the NR1D1 gene on the occurrence, development, and prognosis of colorectal cancer (CRC) using bioinformatics approaches.CRC transcriptomic and clinical data from TCGA were analyzed to compare NR1D1 expression in tumors and various clinical stages.
Xingshu, Zhu, Ming, Wang, Deren, Du, Xueyi, Feng, Zhilong, Huang, Jun, Zhu, Congliang, Rao   +6 more
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[Pulmonary expression of Nr1d1 in rats with ventilation-induced lung injury].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014
To investigate the changes in the expression of nuclear receptor subfamily1 (Nr1d1) in the lungs of rats with ventilation-induced lung injury and explore the molecular mechanism.Seventy-two rats were randomly divided into 4 groups for observation at 4 time points (1:00 AM, 7:00 AM, 1:00 PM and 7:00 PM), and each group was further divided into 3 ...
Jiaqi, Hu, Chunxiao, Wang
openaire   +1 more source