Results 111 to 120 of about 3,079 (182)

Pathogenic NR2F1 Variants Cause a Systemic Neurodevelopmental Ocular Phenotype Recapitulated in a Mutant Mouse Model

, 2021
Pathogenic NR2F1 variants cause a rare autosomal dominant neurodevelopmental disorder - Bosch-Boonstra-Schaaf Optic Atrophy Syndrome (BBSOAS). Although visual loss is a prominent feature seen in affected individuals, the molecular and cellular mechanisms
Neringa Jurkute; Michele Bertacchi; Gavin Arno; Chiara Tocco; Ungsoo Kim; Adam Kruszewski; Robert Avery; Emma Bedoukian; Jinu Han; Sung Ahn; James Acheson; Indran Davagnanam; Richard Bowman; Marios Kaliakatsos; Ashwin Reddy; Ngozi Oluonye; Patrizia Amati-Bonneau; Majida Charif; Guy Lenaers; Isabelle Meunier; Sabine Defoort; Catherine Vincent-Delorme; Anthony Robson; Graham Holder; Luc Jeanjean Jeanjean; Antonio Martinez-Monseny; Grant Liu; Andrew Webster; Michèle Studer; Patrick Yu-Wai-Man
core  

Rôle clé de NR2F1 dans la régulation du destin cellulaire des cellules de la crête neurale [PDF]

Les neurocristopathies sont des pathologies résultant de dysfonctionnements des cellules de la crête neurale (CCN), un groupe de cellules multipotentes et migratoires essentielles au développement de nombreux tissus et organes.
Charrier, Baptiste
core  

Analysis of cis-regulatory changes underlying phenotype divergence shaped by domestication in pigs

Frontiers in Genetics
BackgroundCis-regulatory elements (CREs) are regions of DNA that regulate the expression of nearby genes. Changes in these elements can lead to phenotypic variations and adaptations in different populations.
Chunpeng Liu, Na Ao, Yuwen Liang, Yuwen Liang, Tingting Ma, Tingting Ma, Qishan Wang, Zhen Wang, Fen Wu, Zhenyang Zhang, Yifei Fang, Minghui Wang, Yuchun Pan, Jing Fu, Jing Fu   +14 more
doaj   +1 more source

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +1 more source

PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFRL858R-induced lung cancer progression

Cell Death and Disease
Lung cancer is the major cause of death worldwide. Activation of oncogenes or inhibition of tumor suppressors causes cancer formation. Previous studies have indicated that PTEN, as a tumor suppressor, inhibits cancer formation.
Thi Thanh Truc Tran, Jan-Jong Hung
doaj   +1 more source

上调NR2F1诱导卵巢癌细胞休眠并增强其对化疗药物的抵抗力

Zhongshan Daxue xuebao. Yixue kexue ban
目的探讨NR2F1分子介导的休眠卵巢癌（OC）细胞对化疗药物耐药的分子机制。方法利用GEPIA数据库分析OC患者中NR2F1分子的表达及其与患者总生存期的关系；采用慢病毒体外转染构建核受体亚家族2组F1（NR2F1）过表达的OC细胞株和对照细胞； CCK-8试剂盒检测OC细胞的增殖；实时荧光定量PCR（qRT-PCR）分析OC细胞中休眠相关分子基因mRNA的表达水平；蛋白质免疫印迹试验分析相关分子蛋白表达水平；台盼蓝排除法分析不同化疗药物作用下OC细胞的活力；Annexin V-FITC ...
郭宁, 居颂文
doaj  

NR2F1-associated Dormancy and Glutamine-dependency in H295R Adrenocortical Cancer Cells

ABSTRACT Adrenocortical cancer poses a significant clinical challenge due to its aggressiveness and limited treatment options. Herein, we investigated the role of NR2F1, as a potential dormancy factor, and its relationship with glutamine-dependency of adrenocortical cancer cells.
Yuta Horita, Tomoko Tanaka, Munechika Enjoji, Kenji Ohe   +3 more
openaire   +2 more sources

lncRNA <i>NAS1</i> Deficiency Drives Cisplatin Resistance via NR2F1-Mediated TGFB1/NF-κB Signaling Axis in NSCLC. [PDF]

Cancers (Basel)
Lin X, Wu Y, Wu Q, Tao W, Zhang J, Zhou J.   +5 more
europepmc   +1 more source

Transcription factor NR2F1 is involved in Parkinson’s disease

Neural Regeneration Research
Annemarie de Vries, Silvia Bolognin
openaire   +2 more sources

Transcriptomic Meta-Analysis and Functional Validation Identify Long Non-Coding RNAs as Modulators of Zika Virus-Mediated Oncolysis in Glioblastoma Multiforme Cell Lines. [PDF]

Cells
Singh S, Gerlein M, Horvath AR, Henderson L, Hwang EI, Packer RJ, Shao C, Kousa YA, Mansour TA.   +8 more
europepmc   +1 more source