Results 91 to 100 of about 3,079 (182)

Latest Advances in Obesity Treatment by Regulating Adipocyte Thermogenesis

PPAR Research, Volume 2026, Issue 1, 2026.
Obesity is driven by chronic energy imbalance and is associated with multiple metabolic diseases. As adipocyte thermogenesis contributes to energy expenditure, it is being actively investigated as a possible target for obesity treatment. This review summarizes recent progress in the molecular regulation of adipocyte thermogenesis, focusing mainly on ...
Tao Nie, Jianbin Chen, Zixin Wang, Liufeng Mao, Anjali Chauhan   +4 more
wiley   +1 more source

Upregulation of the Nr2f1-A830082K12Rik gene pair in murine neural crest cells results in a complex phenotype reminiscent of Waardenburg syndrome type 4

Disease Models & Mechanisms, 2016
Waardenburg syndrome is a neurocristopathy characterized by a combination of skin and hair depigmentation, and inner ear defects. In the type 4 form, these defects show comorbidity with Hirschsprung disease, a disorder marked by an absence of neural ...
Karl-F. Bergeron, Chloé M. A. Nguyen, Tatiana Cardinal, Baptiste Charrier, David W. Silversides, Nicolas Pilon   +5 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Nuclear hormone receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S242-S258, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, John A. Cidlowski, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laurel Coons, Peter J. Fuller, Kenneth S. Korach, Donald P. McDonell, Robert Oakley, Sarah Radi, Rachid Safi, Frances Sladek, Morag J. Young   +20 more
wiley   +1 more source

Pathogenic NR2F1 variants cause a developmental ocular phenotype recapitulated in a mutant mouse model.

, 2021
Pathogenic NR2F1 variants cause a rare autosomal dominant neurodevelopmental disorder referred to as the Bosch-Boonstra-Schaaf Optic Atrophy Syndrome. Although visual loss is a prominent feature seen in affected individuals, the molecular and cellular ...

core   +1 more source

Generation of BBSOAS patient-specific induced pluripotent stem cell lines harboring six NR2F1 pathogenic variants

Stem Cell Research
Bosch-Boonstra-Schaaf Optic Atrophy Syndrome (BBSOAS) is a rare autosomal dominant neurodevelopmental disorder caused by mutations or deletions in NR2F1, leading to intellectual disability, developmental delay, visual impairments, epilepsy, hypotonia ...
Michele Bertacchi, Romain Desprat, Gaetan Lesca, Chloé Quelin, Marjolaine Willems, Catherine Vincent-Delorme, Laurence Faivre, Christian Jorgensen, Michèle Studer   +8 more
doaj   +1 more source

Beyond protein-coding genes

eLife, 2019
A long non-coding RNA called lnc-NR2F1 regulates several neuronal genes, including some involved in autism and intellectual disabilities.
Anna Lozano-Ureña, Sacri R Ferrón
doaj   +1 more source

MicroRNA expression analyses in Nr2f1^–/– tissues.

, 2013
(A) The expression of select miRNAs in the Nr2f1–/– inner ear showing miR-140 and miR-181a were significantly down-regulated by 4.5-fold (P=0.004) and 1.7-fold (P=0.046), respectively, compared to the WT. The levels of miR-181b, -181c and -191 were also
Fernanda R. Ruiz (492231), Na Li (6550), Fred A. Pereira (254120), David W. Cuthbertson (492230), David Y. Chiang (389033)   +4 more
core   +1 more source

NR2F1 is a differentially expressed gene in human metastatic breast cancer, in the brain and in the lymph nodes.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans ...
Shahan Mamoor
core   +1 more source

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

eLife, 2019
Long noncoding RNAs (lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions but are often ignored in human genetics.
Cheen Euong Ang, Qing Ma, Orly L Wapinski, ShengHua Fan, Ryan A Flynn, Qian Yi Lee, Bradley Coe, Masahiro Onoguchi, Victor Hipolito Olmos, Brian T Do, Lynn Dukes-Rimsky, Jin Xu, Koji Tanabe, LiangJiang Wang, Ulrich Elling, Josef M Penninger, Yang Zhao, Kun Qu, Evan E Eichler, Anand Srivastava, Marius Wernig, Howard Y Chang   +21 more
doaj   +1 more source

Identification of Long Noncoding RNAs Involved in Differentiation and Survival of Vascular Smooth Muscle Cells

Molecular Therapy: Nucleic Acids, 2020
Long noncoding RNAs (lncRNAs) have recently been implicated in many pathophysiological cardiovascular processes, including vascular remodeling and atherosclerosis.
Yeong-Hwan Lim, Juhee Ryu, Hyun Kook, Young-Kook Kim   +3 more
doaj   +1 more source