Results 71 to 80 of about 3,079 (182)

Long non‐coding NR2F1‐AS1 is associated with tumor recurrence in estrogen receptor‐positive breast cancers

Molecular Oncology, 2020
The tenacity of late recurrence of estrogen receptor (ER)‐positive breast cancer remains a major clinical issue to overcome. The administration of endocrine therapies within the first 5 years substantially minimizes the risk of relapse; however, some ...
Anna Sanchez Calle, Tomofumi Yamamoto, Yumi Kawamura, Ai Hironaka‐Mitsuhashi, Makiko Ono, Hitoshi Tsuda, Akihiko Shimomura, Kenji Tamura, Fumitaka Takeshita, Takahiro Ochiya, Yusuke Yamamoto   +10 more
doaj   +1 more source

Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation

EMBO Reports, 2023
Midbrain dopaminergic neurons (mDANs) control voluntary movement, cognition, and reward behavior under physiological conditions and are implicated in human diseases such as Parkinson’s disease (PD). Many transcription factors (TFs) controlling human mDAN
Borja Gomez Ramos, Jochen Ohnmacht, Nikola de Lange, Elena Valceschini, Aurélien Ginolhac, Marie Catillon, Daniele Ferrante, Aleksandar Rakovic, Rashi Halder, François Massart, Giuseppe Arena, Paul Antony, Silvia Bolognin, Christine Klein, Roland Krause, Marcel H Schulz, Thomas Sauter, Rejko Krüger, Lasse Sinkkonen   +18 more
doaj   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish

PLOS Genetics
Nr2f transcription factors (TFs) are conserved regulators of vertebrate atrial cardiomyocyte (AC) differentiation. However, little is known about the mechanisms directing Nr2f expression in ACs. Here, we identified a conserved enhancer 3’ to the nr2f1a locus, which we call
Ugo Coppola, Bitan Saha, Jennifer Kenney, Joshua S. Waxman   +3 more
openaire   +5 more sources

COUP-TFI deletion affects angiogenesis and apoptosis related gene expression in mouse placenta: results of an explorative study

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Chicken Ovalbumin Upstream Promoter-Transcription Factor I (COUP-TFI) is a member of the steroid/thyroid nuclear receptor superfamily. The aim of this study was to investigate whether absence of this gene affects placental development and ...
Luigi Viola, Stefania Marzinotto, Michele Bertacchi, Ambrogio P Londero, Maria Orsaria, Serena Bertozzi, Lorenza Driul, Carla Di Loreto, Michèle Studer, Laura Mariuzzi, Arrigo Fruscalzo   +10 more
doaj   +1 more source

The spectrum of communication abilities in children with 12 rare neurodevelopmental disorders: a qualitative study with caregivers

Journal of Child Psychology and Psychiatry, Volume 67, Issue 5, Page 740-754, May 2026.
Background Our aim was to update an existing model of communication ability for children with rare neurodevelopmental disorders (NDDs) by centring caregiver and family perspectives. This project is part of a larger initiative to improve the measurement of communication ability for these children in the context of clinical trials.
Christina K. Zigler, Molly McFatrich, Nicole Lucas, Kate Plyler, Leslie Zapata‐Leiva, Kelly Gordon, Harrison N. Jones, Li Lin, Jennifer Kern, Abigail Radar, Dandan Chen, Elika Bergelson, Kate Still, Brigette Hinger, Christal G. Delagrammatikas, Sarah Poliquin, Brittany P. Short, Liz Marfia‐Ash, Kimberly Stephens, Haley O. Oyler, J Michael Graglia, Kali Worth, Charlene Son Rigby, James R. Goss, Bo Bigelow, Geraldine Bliss, Karen Beatty, Leah Schust Myers, Melissa Thelen, Nuala Summerfield, Terry Jo Bichell, Bryce B. Reeve   +31 more
wiley   +1 more source

Use of the Genetic Code Expansion Approach to Study Pathogenic Point Mutations in the NR2F1 gene

, 2023
Le syndrome d'atrophie optique de Bosch-Boonstra-Schaaf (BBSOAS) est une maladie neurodéveloppementale rare causée par des mutations du gène NR2F1, un régulateur transcriptionnel qui joue un rôle clé dans le développement du cerveau.
Phromkrasae, Wanchana
core  

Utilisation de l'approche d'expansion du code génétique pour étudier les mutations ponctuelles du gène NR2F1

, 2023
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is a rare neurodevelopmental disorder caused by mutations of the NR2F1 gene, a transcriptional regulator that plays a key role in brain development.
Phromkrasae, Wanchana
core  

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

Both miR-140 and NR2F1 directly regulate Klf9 expression.

, 2013
(A) Putative miR-140 binding sites (red boxes) on KLF9-3’UTR. (B) Luciferase expression from a KLF9 3'UTR reporter is significantly reduced in the presence of the miR-140 mimic while Luc expression from the empty reporter is unchanged.
Fernanda R. Ruiz (492231), Na Li (6550), Fred A. Pereira (254120), David W. Cuthbertson (492230), David Y. Chiang (389033)   +4 more
core   +1 more source