Results 161 to 170 of about 3,079 (182)

NR2F1 : A Novel Candidate for Gamma Globin Activation

Blood, 2023
The reactivation of human gamma globin holds tremendous promise as a potential treatment for hemoglobinopathies, including sickle cell disease and beta-thalassemia. Despite identifying various repressors of fetal globin genes in adult erythroid cells over the past decade, evidence concerning stage-specific factors that activate human ...
Ruiqiong Wu, Siqi Yi, Yichao Li, Dewan Shrestha, Minzhang Zheng, Jingjing Zhang, Yong Cheng   +6 more
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The emerging role of NR2F1-AS1 in the tumorigenesis and progression of human cancer

Pathology - Research and Practice, 2022
Long noncoding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that lack the ability to encode protein. Convincing studies have indicated that lncRNAs can act as oncogenes or tumor suppressors by regulating gene expression. The novel lncRNA NR2F1-AS1 was recently found to be abnormally expressed in various malignancies, including ...
Dong, Luo, Yunfei, Liu, Shuai, Yuan, Xianyun, Bi, Yongchao, Yang, Hongwei, Zhu, Zhiqiang, Li, LianDong, Ji, Xiao, Yu   +8 more
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Infantile epileptic spasm syndrome as a new NR2F1 gene phenotype

International Journal of Developmental Neuroscience, 2023
AbstractIntroductionNR2F1 pathogenetic variants are associated with the Bosch–Boonstra–Schaaf optic atrophy syndrome (BBSOAS). Recent studies indicate that BBSOAS patients not only have visual impairments but may also have developmental delays, hypotonia, thin corpus callosum and epileptic seizures.
Yan Liang, Lin Wan, Xinting Liu, Jing Zhang, Gang Zhu, Guang Yang   +5 more
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NR2F1 Is a Barrier to Dissemination of Early-Stage Breast Cancer Cells

Cancer Research, 2022
Abstract Cancer cells can disseminate during very early and sometimes asymptomatic stages of tumor progression. Though biological barriers to tumorigenesis have been identified and characterized, the mechanisms that limit early dissemination remain largely unknown.
Carolina Rodriguez-Tirado, Nupura Kale, Maria J. Carlini, Nitisha Shrivastava, Alcina A. Rodrigues, Bassem D. Khalil, Jose Javier Bravo-Cordero, Yan Hong, Melissa Alexander, Jiayi Ji, Fariba Behbod, Maria Soledad Sosa   +11 more
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The relationship of lncRNA NR2F1 and breast cancer angiogenesis via IL-8/lncRNA NR2F1/miR-200s/IL-8 loop.

Journal of Clinical Oncology, 2019
e12573 Background: Angiogenesis is key for metastasis and predicts a poor prognosis in breast cancer. Among the pro-angiogenic factors, interleukin-8 (IL-8) could be secreted by tumor cells mediated by microRNA-200 family (miR-200s). Long non-coding RNA (LncRNA), was reported to absorb microRNA to play multiple roles in various diseases including ...
Qi Zhang, Jin Zhang, Sihong Lu, Nan Shao, Ying Lin   +4 more
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Abstract 2986: NR2F1 underlies persistence of residual disease in melanoma

Cancer Research, 2020
Abstract Despite the clinical success of targeted therapy and checkpoint inhibitors in melanoma, therapeutic responses are transient, followed by relapse that may be driven by a small subpopulation of residual or drug-tolerant cells. Understanding residual disease and metastasis mechanisms can provide clues both for developing improved ...
Manoela Tiago, Jessica L. Teh, Timothy J. Purwin, Weijia Cai, Connor Hollingworth, Melisa Lopez-Anton, Julio A. Aguirre-Ghiso, Andrew E. Aplin   +7 more
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LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis

Expert Review of Molecular Diagnostics, 2023
Previous studies have shown that the differential expression of lncRNA NR2F1-AS1 is closely related to the prognosis of cancer, but the conclusion is still controversial. Therefore, we conducted a meta-analysis and bioinformatics analysis to explore the correlation between LncRNA NR2F1-AS1 and cancer prognosis.From the beginning to January 25, 2023, we
Lu, Tang, Qing-Mei, Liu, Shuang, Zhang, Jun, Zhou   +3 more
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Metabolic Switch Under Glucose Deprivation Leading to Discovery of NR2F1 as a Stimulus of Osteoblast Differentiation

Journal of Bone and Mineral Research, 2020
ABSTRACT Poor survival of grafted cells is the major impediment of successful cell-based therapies for bone regeneration. Implanted cells undergo rapid death in an ischemic environment largely because of hypoxia and metabolic stress from glucose deficiency. Understanding the intracellular metabolic processes and finding genes that can
Eugene Lee, Seo-Young Park, Jae-Yeon Moon, Ji-Yun Ko, Tae Kyung Kim, Gun-Il Im   +5 more
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Nr2f1 controls mitochondrial dynamics in mouse adult-born hippocampal neurons

2022
Abstract The nuclear receptor Nr2f1 plays a key role during cortical development by acting as a strong transcriptional regulator in embryonic and postnatal neural cells. In humans, its mutations cause the Bosch-Boonstra-Schaaf optic atrophy-intellectual syndrome (BBSOAS), a rare neurodevelopmental disorder ...
Bonzano Sara, Michelon Filippo, Crisci Isabella, Molineris Ivan, Neri Francesco, Oliviero Salvatore, Beckervordersandforth Ruth, Lie Dieter Chichung, Peretto Paolo, Bovetti Serena, Studer Michèle, De Marchis Silvia   +11 more
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Unravelling the conundrum of nucleolar NR2F1 localization: A comparative analysis of NR2F1 antibody-based approaches in vitro and in vivo

ABSTRACT As a transcription factor, NR2F1 regulates spatiotemporal gene expression during development and in adulthood. Aberrant NR2F1 causes a rare neurodevelopmental disorder known as Bosch-Boonstra- Schaaf Optic Atrophy Syndrome.
Michele Bertacchi, Susanne Theiß, Ayat Ahmed, Michael Eibl, Agnès Loubat, Gwendoline Maharaux, Wanchana Phromkrasae, Krittalak Chakrabandhu, Aylin Camgöz, Christian Schaaf, Michèle Studer, Magdalena Laugsch   +11 more
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