Results 171 to 180 of about 179,291 (216)

Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling. [PDF]

Antioxidants (Basel)
Khan A, Xiong Z, Khan IA, Cheng X, Luo Q, Jia L, Liu W, Huang C, Chen Z.   +8 more
europepmc   +1 more source

Melatonin ameliorates TNFα-induced oral epithelial cell inflammation via Keap1-Nrf2 axis modulation. [PDF]

Am J Transl Res
Wang S, Wang W, Zhang R, Liu Y, Wang Y, Bai Y, Bai Y.   +6 more
europepmc   +1 more source

Establishment of a 3D Multicellular HCC Tumor Spheroid Model to Unravel Nrf2's Influence on the Tumor Immune Microenvironment. [PDF]

Bioengineering (Basel)
Böttcher N, Krumm P, Huchzermeier R, Berschkeit L, Vollmer J, Dick J, Pufe T, Fragoulis A.   +7 more
europepmc   +1 more source

Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway. [PDF]

Biol Direct
Zhang H, Zhang D, Wang Z, Liu K, Xu C, Sun H, Yan Z, Li C, Lu B, Yin Y, Zhao C, Niu Y, Li W.   +12 more
europepmc   +1 more source

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NRF2: KEAPing Tumors Protected

Cancer Discovery, 2022
AbstractThe Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of ...
Ray Pillai, Makiko Hayashi, Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos   +3 more
openaire   +2 more sources

Nrf2 in adipocytes

Archives of Pharmacal Research, 2020
White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivotal in energy storage and metabolism.
Zhendi, Wang, Zhuo, Zuo, Lu, Li, Suping, Ren, Tianchang, Gao, Jingqi, Fu, Yongyong, Hou, Yanyan, Chen, Jingbo, Pi   +8 more
openaire   +2 more sources

Mazes of Nrf2 regulation

Biochemistry (Moscow), 2017
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid ...
N K, Zenkov, P M, Kozhin, A V, Chechushkov, G G, Martinovich, N V, Kandalintseva, E B, Menshchikova   +5 more
openaire   +2 more sources

Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface

Bioorganic & Medicinal Chemistry, 2016
The discovery of Keap1-Nrf2 protein-protein interaction (PPI) inhibitors has become a promising strategy to develop novel lead molecules against variety of stress. Hence, Keap1-Nrf2 system plays an important role in oxidative/electrophilic stress associated disorders. Our earlier studies identified pterostilbene (PTS), a natural analogue of resveratrol,
Elango, Bhakkiyalakshmi, Kesavan, Dineshkumar, Suresh, Karthik, Dornadula, Sireesh, Waheeta, Hopper, Ramasamy, Paulmurugan, Kunka Mohanram, Ramkumar   +6 more
openaire   +2 more sources

Unfolding Nrf2 in diabetes mellitus

Molecular Biology Reports, 2021
In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all over the globe. Free radicals cause oxidative stress which is responsible for causing diabetes. The recent advancements in elucidation of ARE/keap1/Nrf2 pathway can help in better understanding of diabetes mellitus.
Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Eshita Sharma, Arun Kumar, Madhuri Grover, Simona Bungau   +6 more
openaire   +2 more sources