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Food & Function, 2021
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD.
Jingda Li +6 more
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Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD.
Jingda Li +6 more
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Regulation of Nrf2 and Nrf2-related proteins by ganoderma lucidum ın hepatocellular carcinoma
Molecular Biology Reports, 2022HCC is among the most common cancer. Ganoderma lucidum (G.lucidum) has been essential in preventing and treating cancer. The Nrf2 signaling cascade is a cell protective mechanism against further damage, such as cancer development. This signaling pathway upregulates the cytoprotective genes and is vital in eliminating xenobiotics and reactive oxygen ...
Ramin Aslaminabad +11 more
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Carbohydrate Polymers
The occurrence and development of many diseases are closely related to oxidative stress. In this context, accumulating evidence suggests that Nrf2, as the master switch of cellular antioxidant signaling, plays a central role in controlling the expression
Nuo Chen +4 more
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The occurrence and development of many diseases are closely related to oxidative stress. In this context, accumulating evidence suggests that Nrf2, as the master switch of cellular antioxidant signaling, plays a central role in controlling the expression
Nuo Chen +4 more
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The Dual Roles of NRF2 in Cancer
Trends in Molecular Medicine, 2016NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress. However, several recent studies demonstrate that hyperactivation of the NRF2 pathway creates an environment that ...
Menegon, S +2 more
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Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms
Journal of Cellular Physiology, 2020Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant titer. Toxic insults and many other diseased conditions are mediated through the formation of such condition.
Pallab Shaw, A. Chattopadhyay
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NRF2 activation in cancer and overview of NRF2 small molecule inhibitors
Archives of Pharmacal ResearchNRF2 is a redox-sensitive transcription factor that activates the expression of phase II detoxifying and antioxidant enzymes. In addition to maintaining redox homeostasis, NRF2 regulates various other processes, including metabolism, stem cell renewal, mitochondrial function, and proteostasis.
Hoang Hai Ngo +4 more
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Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface
Bioorganic & Medicinal Chemistry, 2016The discovery of Keap1-Nrf2 protein-protein interaction (PPI) inhibitors has become a promising strategy to develop novel lead molecules against variety of stress. Hence, Keap1-Nrf2 system plays an important role in oxidative/electrophilic stress associated disorders. Our earlier studies identified pterostilbene (PTS), a natural analogue of resveratrol,
Elango, Bhakkiyalakshmi +6 more
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Biochemical and Biophysical Research Communications - BBRC, 1997
K. Itoh +11 more
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K. Itoh +11 more
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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
Annual Review of Pharmacology and Toxicology, 2007T. Kensler, N. Wakabayashi, S. Biswal
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2011
Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
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Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
openaire +1 more source