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Correction to "4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly via Activating the NRF2/HO-1 Signaling Pathway". [PDF]

J Cell Mol Med
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NRF2: KEAPing Tumors Protected

Cancer Discovery, 2022
AbstractThe Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of ...
Ray Pillai, Makiko Hayashi, Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos   +3 more
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Nrf2 in adipocytes

Archives of Pharmacal Research, 2020
White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivotal in energy storage and metabolism.
Zhendi, Wang, Zhuo, Zuo, Lu, Li, Suping, Ren, Tianchang, Gao, Jingqi, Fu, Yongyong, Hou, Yanyan, Chen, Jingbo, Pi   +8 more
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Mazes of Nrf2 regulation

Biochemistry (Moscow), 2017
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid ...
N K, Zenkov, P M, Kozhin, A V, Chechushkov, G G, Martinovich, N V, Kandalintseva, E B, Menshchikova   +5 more
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Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.

Food & Function, 2021
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD.
Jingda Li, Tianqi Wang, Panpan Liu, Fuyuan Yang, Xudong Wang, Weilong Zheng, Wenlong Sun   +6 more
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Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface

Bioorganic & Medicinal Chemistry, 2016
The discovery of Keap1-Nrf2 protein-protein interaction (PPI) inhibitors has become a promising strategy to develop novel lead molecules against variety of stress. Hence, Keap1-Nrf2 system plays an important role in oxidative/electrophilic stress associated disorders. Our earlier studies identified pterostilbene (PTS), a natural analogue of resveratrol,
Elango, Bhakkiyalakshmi, Kesavan, Dineshkumar, Suresh, Karthik, Dornadula, Sireesh, Waheeta, Hopper, Ramasamy, Paulmurugan, Kunka Mohanram, Ramkumar   +6 more
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Unfolding Nrf2 in diabetes mellitus

Molecular Biology Reports, 2021
In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all over the globe. Free radicals cause oxidative stress which is responsible for causing diabetes. The recent advancements in elucidation of ARE/keap1/Nrf2 pathway can help in better understanding of diabetes mellitus.
Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Eshita Sharma, Arun Kumar, Madhuri Grover, Simona Bungau   +6 more
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Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

Journal of Cellular Physiology, 2020
Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant titer. Toxic insults and many other diseased conditions are mediated through the formation of such condition.
Pallab Shaw, A. Chattopadhyay
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