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Nrf2 protects against airway disorders
Toxicology and Applied Pharmacology, 2010Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor that regulates antioxidant response elements (AREs)-mediated expression of antioxidant enzyme and cytoprotective proteins. In the unstressed condition, Kelch-like ECH-associated protein 1 (Keap1) suppresses cellular Nrf2 in cytoplasm and drives its ...
Hye-Youn, Cho, Steven R, Kleeberger
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การควบคุมเหนือพันธุกรรมของยีน Nrf2 โดยอนุพันธ์ออกซิเจนที่ว่องไวต่อการลุกลามของมะเร็งตับ
2023อนุพันธ์ออกซิเจนที่ว่องไวถูกสร้างมากขึ้นในมะเร็งมะเร็งทุกชนิดรวมทั้งมะเร็งตับ ทำให้เกิดภาวะเครียดจากออกซิเดชั่นในสภาวะแวดล้อมมะเร็ง (tumor microenvironment) ในงานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาการแสดงออกของ Nuclear factor erythroid 2-related factor 2 (Nrf2) และ 8-hydroxydeoxyguanosine (8-OHdG) ในชิ้นเนื้อมะเร็งจากผู้ป่วยมะเร็งตับและในเซลล์มะเร็งต ...
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Nrf2, a multi‐organ protector?
The FASEB Journal, 2005ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that binds to the promoter sequence “antioxidant responsive element (ARE)” leading to coordinated up‐regulation of ARE‐driven detoxification and antioxidant genes.
Jong-Min, Lee +7 more
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Biochemical Society. Transactions, 2015
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various other functions in a cell-type specific manner. Due to these key functions, a tight control of NRF2 expression and activity is essential.
Kurinna, Svitlana, Werner, Sabine
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The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various other functions in a cell-type specific manner. Due to these key functions, a tight control of NRF2 expression and activity is essential.
Kurinna, Svitlana, Werner, Sabine
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2011
Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
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Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
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2022
Breast cancer is still one of the leading cause of morality in women. Despite of all measures for early detection and prevention, there is no significant progress in the survival rates. One of the reasons for this is therapy resistance. Aquaporins, firstly described as cellular plumbing system, provided mechanisms for cancer cell motility and ...
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Breast cancer is still one of the leading cause of morality in women. Despite of all measures for early detection and prevention, there is no significant progress in the survival rates. One of the reasons for this is therapy resistance. Aquaporins, firstly described as cellular plumbing system, provided mechanisms for cancer cell motility and ...
openaire
American Journal of Respiratory and Critical Care Medicine, 2010
Raju C. Reddy, Theodore J. Standiford
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Raju C. Reddy, Theodore J. Standiford
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