Results 261 to 270 of about 115,081 (308)

P62 in colorectal cancer: from inflammation suppression to cancer promotion. [PDF]

Front Immunol
A N, Huang J, Liu L, Chen H, Chen J, Zou S, Pang Y, Wu X, Liu M, Liang G.   +9 more
europepmc   +1 more source

LRRC8A Inhibition Overcomes Chemoresistance by Downregulating MRP3 and CYP3A4 in the 3D Spheroid Model of Human Breast Cancer Cells. [PDF]

Int J Mol Sci
Otsuka R, Kajikuri J, Matsui M, Kito H, Kitahara A, Mitsui H, Yamaguchi Y, Hisada T, Toyama T, Ohya S.   +9 more
europepmc   +1 more source

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Nrf2 signaling in coordinated activation of antioxidant gene expression

Free Radical Biology and Medicine, 2004
Antioxidant response element (ARE)-mediated expression and coordinated induction of antioxidant enzymes is a critical mechanism of protection against chemically induced oxidative/electrophilic stress. NF-E2-related nuclear factors (Nrf1 and Nrf2) bind to ARE and regulate ARE-mediated gene expression and induction.
openaire   +4 more sources

Nrf2 Regulates Thromboxane Synthase Gene Expression in Human Lung Cells

DNA and Cell Biology, 2003
Thromboxane A(2) synthase (TXAS) converts prostaglandin H(2) to thromboxane A(2), a potent inducer of vaso-constriction and platelet aggregation. TXAS expression level is cell type preferential; high in hematopoietic cells and low in nonhematopoietic cells.
Masahiro, Yaekashiwa, Lee-Ho, Wang
openaire   +2 more sources

Liver expression of Nrf2-related genes in different liver diseases

Hepatobiliary & Pancreatic Diseases International, 2015
The KEAP1-Nrf2 antioxidant signaling pathway is important in protecting liver from various insults. However, little is known about the expression of Nrf2-related genes in human liver in different diseases.This study utilized normal donor liver tissues (n=35), samples from patients with hepatocellular carcinoma (HCC, n=24), HBV-related cirrhosis (n=27),
Ming-Liang, Cheng, Yuan-Fu, Lu, Hong, Chen, Zhong-Yang, Shen, Jie, Liu   +4 more
openaire   +2 more sources

Gene expression profiling of NRF2-mediated protection against oxidative injury

Free Radical Biology and Medicine, 2005
Nuclear factor E2 p45-related factor 2 (NRF2) contributes to cellular protection against oxidative insults and chemical carcinogens via transcriptional activation of antioxidant/detoxifying enzymes. To understand the molecular basis of NRF2-mediated protection against oxidative lung injury, pulmonary gene expression profiles were characterized in Nrf2 ...
Hye-Youn, Cho, Sekhar P, Reddy, Andrea, Debiase, Masayuki, Yamamoto, Steven R, Kleeberger   +4 more
openaire   +2 more sources

Nrf2 signaling in heart failure: expression of Nrf2, Keap1, antioxidant, and detoxification genes in dilated or ischemic cardiomyopathy

Physiological Genomics, 2022
Increased levels of oxidative stress have been found with heart failure. Whether failing hearts express antioxidant and detoxification enzymes have not been addressed systematically. Nrf2 gene encodes a transcription factor that regulates the expression of antioxidant and detoxification genes.
Yingying Lu, Lingling An, Matthew R. G. Taylor, Qin M. Chen   +3 more
openaire   +2 more sources

Abstract A41: Regulation of Nrf2-dependent gene expression in aging

Cancer Prevention Research, 2010
Abstract Nrf2 is a transcription factor which controls induction of antioxidant and detoxification enzymes, and, therefore, plays an essential role in protection against chemical carcinogens. Here, we reported that expression of Nrf2 and its dependent genes was affected by age and became compromised in aged mouse livers.
Quan Ma, Zheyi Han, Rong Yu
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CYP2E1 Impairs GLUT4 Gene Expression and Function: NRF2 as a Possible Mediator

Hormone and Metabolic Research, 2014
Impaired GLUT4 function/expression in insulin target tissues is well-documented in diabetes and obesity. Cytochrome P450 isoform 2E1 (CYP2E1) induces oxidative stress, leading to impaired insulin action. CYP2E1 knockout mice are protected against high fat diet-induced insulin resistance and obesity; however the molecular mechanisms are still unclear ...
M, Armoni, C, Harel, M, Ramdas, E, Karnieli   +3 more
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Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

Free Radical Biology and Medicine, 2009
The J series of cyclopentenone prostaglandins (PGs) such as 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) are electrophilic lipid signaling mediators derived from the nonenzymatic dehydration of PGD(2), a major product of the cyclooxygenase pathway. The biological actions of 15d-PGJ(2) are attributed to its ability to form covalent adducts with thiol ...
Emilia, Kansanen, Annukka M, Kivelä, Anna-Liisa, Levonen   +2 more
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