Results 271 to 280 of about 115,081 (308)

Ochratoxin A impairs Nrf2‐dependent gene expression in porcine kidney tubulus cells

Journal of Animal Physiology and Animal Nutrition, 2009
SummaryThe mycotoxin, ochratoxin A (OTA), which is produced by Aspergillus and Penicillium subspecies, is frequently present in feedstuffs. Ochratoxin A exhibits a wide range of toxic activities including nephrotoxicity. However, the underlying molecular mechanisms of OTA‐induced cellular nephrotoxicity have yet not been fully elucidated.
C, Boesch-Saadatmandi, A E, Wagner, A C, Graeser, C, Hundhausen, S, Wolffram, G, Rimbach   +5 more
openaire   +2 more sources

Association between plasma selenium level and NRF2 target genes expression in humans

Journal of Trace Elements in Medicine and Biology, 2015
Animal studies in rodent and in vitro studies indicate compensatory role of nuclear factor (erythroid-derived 2)-like (Nrf2) and Nrf2-regulated antioxidant and phase II biotransformation enzymes for the dietary selenium (Se) deficiency or for the loss of selenoproteins.
Edyta, Reszka, Edyta, Wieczorek, Ewa, Jablonska, Beata, Janasik, Wojciech, Fendler, Wojciech, Wasowicz   +5 more
openaire   +2 more sources

Gene expression changes induced by skin sensitizers in the KeratinoSens™ cell line: Discriminating Nrf2-dependent and Nrf2-independent events

Toxicology in Vitro, 2013
The KeratinoSens™ assay is an in vitro screen for the skin sensitization potential of chemicals. It is based on a luciferase reporter gene under the control of the antioxidant response element of the aldoketoreductase gene AKR1C2. The transferability, reproducibility, and predictivity of the KeratinoSens™ assay have been investigated in detail and it ...
Emter, Roger, van der Veen, Jochem W., Adamson, Greg, Ezendam, Janine, van Loveren, Henk, Natsch, Andreas   +5 more
openaire   +3 more sources

Nrf2 target gene expression through the panin progression in pancreatic oncogenesis

Pancreatology, 2012
s / Pancreatology 12 (2012) e1–e8 e4 Take-home message: Distal bile duct adenocarcinoma is a rare malignancy with not well known prognostic factors. In this large DBDA series has been shown that younger patients withwell differentiated DBDA and 2 or less involved LNs have longer survival post radical resection.
A.J. Hayes, B. Haugk, F. Oakley, M. Walsh, D.A. Mann, R.M. Charnley   +5 more
openaire   +1 more source

Induction of NRF2‐mediated gene expression by dietary phytochemical flavones apigenin and luteolin

Biopharmaceutics & Drug Disposition, 2015
AbstractApigenin (API) and luteolin (LUT) have been used as therapeutic agents in folk medicine for thousands of years. These compounds exert a variety of biological activities, including anticancer, antioxidant and antiinflammatory activities. This study investigated whether API and LUT could activate Nrf2‐antioxidant response element (ARE)‐mediated ...
Paredes, X., Fuentes Carmona, Francisco Fabián, Jeffery, S., Saw, C., Shu, L., Su, Z., Kong, A.   +6 more
openaire   +3 more sources

Regulation of aldo–keto reductase AKR1B10 gene expression: Involvement of transcription factor Nrf2

Chemico-Biological Interactions, 2011
Aldo-keto reductase 1B10 (AKR1B10) is an aldose reductase-like oxidoreductase of human origin. The expression of AKR1B10 is highly induced in the cells of various cancers such as lung non-small-cell carcinoma and hepatocellular carcinoma. Since the enzyme exhibits broad substrate specificities toward various xenobiotics such as anti-tumor drugs or ...
Toru, Nishinaka, Takeshi, Miura, Manami, Okumura, Fumika, Nakao, Haruka, Nakamura, Tomoyuki, Terada   +5 more
openaire   +2 more sources

Response of the brain to oligemia: gene expression, c-Fos, and Nrf2 localization

Molecular Brain Research, 2004
Oligemia is blood flow reduction without acute tissue damage that occurs in shock, migraine, and stroke penumbra. We developed a mouse model of oligemia by lowering mean arterial pressure to 30-40 mm Hg, resulting in a 50% reduction in cerebral blood flow as measured by laser Doppler, and reperfusing the blood after 30 min. Control experiments included
Christopher S, Liverman, Lisa, Cui, Chi, Yong, Rajani, Choudhuri, Robert M, Klein, K Michael A, Welch, Nancy E J, Berman   +6 more
openaire   +2 more sources

Relationship between Radiosensitivity and Nrf2 Target Gene Expression in Human Hematopoietic Stem Cells

Radiation Research, 2010
NFE2-related factor 2 (Nrf2), which belongs to the cap "n" collar family of basic region leucine zipper transcription factors, is a key protein in the coordinated transcriptional induction of expression of various antioxidant genes. The purpose of this study was to analyze the expression of Nrf2 target genes, such as heme oxygenase 1 (HO-1), ferritin ...
Kengo, Kato, Kenji, Takahashi, Satoru, Monzen, Hiroyuki, Yamamoto, Atsushi, Maruyama, Ken, Itoh, Ikuo, Kashiwakura   +6 more
openaire   +2 more sources

Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse

Biochemical and Biophysical Research Communications, 2003
The arylhydrocarbon receptor (AhR) regulates the expression of cytochrome P450 (CYP)-1 gene family members which catalyze xenobiotic Phase I metabolism, while Nrf2 exerts the concerted regulation of Phase II enzyme genes. We generated AhR and Nrf2 compound null mutant mice to examine the integrated function of AhR- and Nrf2-regulated enzymes in ...
Shuhei, Noda, Nobuhiko, Harada, Azumi, Hida, Yoshiaki, Fujii-Kuriyama, Hozumi, Motohashi, Masayuki, Yamamoto   +5 more
openaire   +2 more sources

3,3′-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts

Free Radical Research, 2011
There is increasing interest in the gene-regulatory activity of Brassica vegetable derived phytochemicals such as 3,3'-diindolylmethane (DIM) and indole-3-carbinol (I3C). DIM is formed under acidic conditions by dimerization of I3C. This study compared the Nrf2 activating potential of DIM and I3C in murine fibroblasts (NIH3T3).
I M A, Ernst, C, Schuemann, A E, Wagner, G, Rimbach   +3 more
openaire   +2 more sources