Results 271 to 280 of about 92,480 (295)

Nrf2—A regulator of keratinocyte redox signaling

Free Radical Biology and Medicine, 2015
The skin is frequently exposed to environmental challenges, such as UV irradiation, toxic chemicals, and mechanical wounding. These insults cause an increase in the levels of reactive oxygen species, resulting in oxidative stress and concomitant inflammation, skin aging, and even cancer development.
Matthias Schäfer, Sabine Werner
openaire   +3 more sources

Exercise-induced Nrf2-signaling is impaired in aging

Free Radical Biology and Medicine, 2016
The transcription factor nuclear erythroid-2 like factor-2 (Nrf2) is the master regulator of antioxidant defense. Data from animal studies suggest exercise elicits significant increases in Nrf2 signaling, and that signaling is impaired with aging resulting in decreased induction of phase II detoxifying enzymes and greater susceptibility to oxidative ...
Matthew J Gage, Tinna Traustadóttir
exaly   +3 more sources

Nrf2/ARE axis signalling in hepatocyte cellular death

Molecular Biology Reports, 2022
The Nrf2-ARE transcriptional pathway plays an important role amongst cellular defence systems regulating and ensuring adequacy of redox responses and oxidant signalling factors. Hepatocyte cellular death and injury is a prominent feature underlying liver pathologies.
Bayan Y. Ghanim, Nidal A. Qinna
openaire   +2 more sources

Nrf2 Signaling in Viral Infections

Reactive Oxygen Species, 2022
Nrf2 is a central regulator of cellular antioxidant and other cytoprotective genes. Several recent studies revealed a novel role for Nrf2 signaling in protecting against viral infections, including COVID-19. The findings from these studies pointed to a feasibility for treating viral infections, including COVID-19, via pharmacological activation of the ...
openaire   +1 more source

Role of the Nrf2 signaling system in health and disease

Clinical Genetics, 2014
A key component of cytoprotective gene regulation is the transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2), also known as nuclear factor erythroid 2‐like 2, from the gene NFE2L2. Under normal conditions, Nrf2 in the cell is targeted for proteasomal degradation by its inhibitor Kelch‐like ECH‐associated inhibitor 1 (Keap1).
B M, Hybertson, B, Gao
openaire   +2 more sources

The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer

Antioxidants & Redox Signaling, 2010
The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight regulation is crucial to maintain cellular homeostasis. Activation of this pathway is important in preventing human diseases, such as cancer, neurodegenerative disease,
openaire   +2 more sources

The Nrf2-Keap1/ARE signaling pathway in aquatic animals

International Journal of Biological Macromolecules
The complex and fluctuating conditions of aquatic ecosystems make aquatic organisms vulnerable to oxidative stress. The Nrf2-Keap1/ARE signaling pathway serves as an important intracellular defense mechanism, particularly for aquatic organisms exposed to environmental stressors and toxic substances.
Bo-Ping Tang, Qiu-Ning Liu
exaly   +3 more sources

The Study of Nrf2 Signaling Pathway in Ovarian Cancer

Critical Reviews in Eukaryotic Gene Expression, 2018
Ovarian cancer is one of the most malignant gynecological tumors in the world, with a high fatality rate and resistance to chemotherapy. Much basic research has revealed that oxidative stress is involved in tumor occurrence and development processes and is associated with tumor progression as well as metastasis.
Xiaotong, Wu, Li Ying, Han, Xiao Xiao, Zhang, Ling, Wang   +3 more
openaire   +2 more sources

Redox-dependent signaling system Nrf2/ARE in inflammation

Molecular Biology, 2010
Transcription factor Nrf2 plays a key role in cell defense against oxidative stress, as well as in counteracting chemical and physical factors that induce apoptosis and carcinogenesis. The mechanism of Nrf2/ARE redox regulation and ARE-mediated gene expression are analyzed in the review.
E B, Men'shikova, V O, Tkachev, N K, Zenkov   +2 more
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Regulation of Nrf2 Signaling.

Reactive oxygen species (Apex, N.C.)
Regulation of antioxidant gene expression is essential for controlling oxidative stress and maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 (Nrf2) has been identified as the chief regulator of the transcription of diverse antioxidant genes as well as many other cytoprotective genes.
Robert, Li, Zhenquan, Jia, Hong, Zhu
openaire   +1 more source