Results 261 to 270 of about 92,480 (295)

AlCl₃ exposure induces nephrotoxicity in mice by mediating ferroptosis through the NRF2 signaling pathway. [PDF]

Front Toxicol
Liang LD, Zhao XY, Li L, Liang S, Zhang JM, Lv JN, Deng FL, Lu CL, Li Q, Huang QW, Huang MJ, Peng HX.   +11 more
europepmc   +1 more source

RETRACTION: Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice. [PDF]

Oxid Med Cell Longev
Cellular Longevity OMA.
europepmc   +1 more source

Ferroptosis and Nrf2 Signaling in Head and Neck Cancer: Resistance Mechanisms and Therapeutic Prospects. [PDF]

Antioxidants (Basel)
Lee J, Seo Y, Roh JL.
europepmc   +1 more source

Sulforaphane improves exercise-induced NRF2 signaling in older adults: an in vivo-ex vivo approach. [PDF]

Geroscience
Rodriguez DJ, Ostrom EL, Chassman C, Robertson J, Pan V, Buscaglia R, Eggler AL, Traustadóttir T.   +7 more
europepmc   +1 more source

Dietary urolithin a improves hepatic antioxidant function and laying performance in aging hens via Nrf2 signaling pathway activation. [PDF]

Poult Sci
Wu L, Zhang Y, Peng L, Ye L, Zhao X.
europepmc   +1 more source

The KEAP1/NRF2 Signaling Pathway in Keratinization

Antioxidants, 2020
Keratinization is a tissue adaptation, but aberrant keratinization is associated with skin disorders such as ichthyoses, atopic dermatitis, psoriasis, and acne. The disease phenotype stems from the interaction between genes and the environment; therefore,
Yosuke Ishitsuka, Tatsuya Ogawa, Dennis R Roop   +2 more
exaly   +5 more sources

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Understanding the Role of NRF2 Signalling in Cancer

Current Protein & Peptide Science, 2022
Abstract: Nuclear factor erythroid 2 (NFE 2) - related factor 2 (NFE2L2 or NRF2) is one of the transcription factors predominantly related to the expression of antioxidant genes. NRF2 plays a pivotal role in controlling redox potential in several tumor characteristics, including cancer cell metabolism, stem-cell-like characteristics, tumor ...
Kanthesh M. Basalingappa, Pooja G. Singh, T.S. Gopenath, Ramesh Bharadwaj MN, R. Ilangovan   +4 more
openaire   +2 more sources

Regulation of Nrf2 Signaling

Reactive Oxygen Species, 2019
Regulation of antioxidant gene expression is essential for controlling oxidative stress and maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 (Nrf2) has been identified as the chief regulator of the transcription of diverse antioxidant genes as well as many other cytoprotective genes.
Y. Li, Zhenquan Jia, Hong Zhu
openaire   +1 more source

Mechanism of the Nrf2/Keap1/ARE signaling system

Biochemistry (Moscow), 2011
Nrf2 regulates expression of genes containing antioxidant-respons(iv)e element (ARE) in their promoters and plays a pivotal role among all redox-sensitive transcription factors. Nrf2 is constitutively controlled by repressor protein Keap1, which acts as a molecular sensor of disturbances in cellular homeostasis.
V O, Tkachev, E B, Menshchikova, N K, Zenkov   +2 more
openaire   +2 more sources