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The Study of Nrf2 Signaling Pathway in Ovarian Cancer
Critical Reviews in Eukaryotic Gene Expression, 2018Ovarian cancer is one of the most malignant gynecological tumors in the world, with a high fatality rate and resistance to chemotherapy. Much basic research has revealed that oxidative stress is involved in tumor occurrence and development processes and is associated with tumor progression as well as metastasis.
Xiaotong, Wu +3 more
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Redox-dependent signaling system Nrf2/ARE in inflammation
Molecular Biology, 2010Transcription factor Nrf2 plays a key role in cell defense against oxidative stress, as well as in counteracting chemical and physical factors that induce apoptosis and carcinogenesis. The mechanism of Nrf2/ARE redox regulation and ARE-mediated gene expression are analyzed in the review.
E B, Men'shikova +2 more
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Reactive oxygen species (Apex, N.C.)
Regulation of antioxidant gene expression is essential for controlling oxidative stress and maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 (Nrf2) has been identified as the chief regulator of the transcription of diverse antioxidant genes as well as many other cytoprotective genes.
Robert, Li, Zhenquan, Jia, Hong, Zhu
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Regulation of antioxidant gene expression is essential for controlling oxidative stress and maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 (Nrf2) has been identified as the chief regulator of the transcription of diverse antioxidant genes as well as many other cytoprotective genes.
Robert, Li, Zhenquan, Jia, Hong, Zhu
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KEAP1/NRF2 SIGNALING IN AGED BONE
Bone health is a critical element in mammalian quality of life. The Keap1/Nrf2 signaling pathway has recently been observed to be instrumental in a multitude of regulatory processes pertaining to cytoprotective gene expression, with growing evidence of its role in bone metabolism.openaire +1 more source
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
Drug Metabolism Reviews, 2006Since eukaryotic cells constantly encounter various environmental insults, they have evolved defense mechanisms to cope with toxicant- and carcinogen-induced oxidative stress or electrophiles. One of the most important cellular defense mechanisms against oxidative stress or electrophiles is mediated by the transcription factor Nrf2.
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The Nrf2-Keap1/ARE signaling pathway in aquatic animals
International Journal of Biological MacromoleculesThe complex and fluctuating conditions of aquatic ecosystems make aquatic organisms vulnerable to oxidative stress. The Nrf2-Keap1/ARE signaling pathway serves as an important intracellular defense mechanism, particularly for aquatic organisms exposed to environmental stressors and toxic substances.
Dan-Dan, Bian +9 more
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